A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

Metabolic Engineering

Volumn 37, Issue , 2016, Pages 46-62

  Savoglidis, Georgios ^a   da Silveira dos Santos, Aline Xavier ^b,c   Riezman, Isabelle ^b   Angelino, Paolo ^a   Riezman, Howard ^b,c   Hatzimanikatis, Vassily ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c National Center of Competence in Research 'Chemical Biology'   (Switzerland)

Author keywords

Inverse metabolic engineering; Lipid metabolism; Lipidomics; Nonlinear kinetic models; Sphingolipid regulation; Strain design

Indexed keywords

BIOCHEMISTRY; ENZYMES; INVERSE PROBLEMS; KINETIC PARAMETERS; KINETIC THEORY; KINETICS; METABOLISM; PHYSIOLOGY; SYNTHESIS (CHEMICAL); YEAST;

INVERSE METABOLIC ENGINEERING; LIPID METABOLISMS; LIPIDOMICS; NONLINEAR KINETICS; SPHINGOLIPIDS;

METABOLIC ENGINEERING;

LYASE; PHOSPHOLIPASE; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE LYASE; UNCLASSIFIED DRUG; PHOSPHOLIPASE D; SACCHAROMYCES CEREVISIAE PROTEIN; SPO14 PROTEIN, S CEREVISIAE;

ANALYTIC METHOD; ARTICLE; ENZYME ACTIVITY; HYDROXYLATION; INVERSE METABOLIC CONTROL ANALYSIS; KINETICS; LIPIDOMICS; LIPOGENESIS; METABOLIC ENGINEERING; METABOLIC REGULATION; METABOLOMICS; METHODOLOGY; MODEL; MOLECULAR DYNAMICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; REVERSE ENGINEERING; SACCHAROMYCES CEREVISIAE; SPHINGOLIPID METABOLISM; THERMODYNAMICS; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENE EXPRESSION PROFILING; GENETICS; METABOLIC FLUX ANALYSIS; METABOLISM; METABOLOME; PHYSIOLOGY; PROCEDURES;

COMPUTER SIMULATION; GENE EXPRESSION PROFILING; KINETICS; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MODELS, BIOLOGICAL; PHOSPHOLIPASE D; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPHINGOLIPIDS;

EID: 84966304379     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.04.002     Document Type: Article

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