Nonlinear Metabolic Control Analysis

Metabolic Engineering

Volumn 1, Issue 1, 1999, Pages 75-87

  Hatzimanikatis, Vassily ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; METABOLISM; NONLINEAR SYSTEM; THEORETICAL MODEL;

METABOLISM; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NONLINEAR DYNAMICS;

EID: 0032600734     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1006/mben.1998.0108     Document Type: Article

References (13)

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3. Fell D. A. Metabolic control analysis: A survey of its theoretical and experimental development. Biochem. J. 286:1992;3133-3130.
4. Fell D. Understanding the Control of Metabolism. 1997;Portland Press, London.
5. Goldbeter A., Koshland D. E. An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl. Acad. Sci. USA. 78:1981;6840-6844.
6. Hatzimanikatis V., Bailey J. E. Effects of spatiotemporal variations on metabolic control: Approximate analysis using (log)linear kinetic models. Biotechol. Bioeng. 54:1997;91-104.
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9. Kacser H., Acerenza L. A universal method for achieving increases in metabolite production. Eur. J. Biochem. 216:1993;361-367.
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11. Reder C. Metabolic control theory: A structural approach. J. Theor. Biol. 135:1988;175-201.
12. Small J. R., Kacser H. Response of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains. Eur. J. Biochem. 213:1993;613-624.
13. Small J. R., Kacser H. Response of metabolic systems to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations. Assement of the general non-linear case. Eur. J. Biochem. 213:1993;625-640.