Update on the heritability of inflammatory bowel disease: The importance of twin studies

Inflammatory Bowel Diseases

Volumn 17, Issue 1, 2011, Pages 1-5

  Brant, Steven R ^a,b  

^a Institute for Cell Engineering   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

CROHN DISEASE; FAMILIAL DISEASE; FAMILY HISTORY; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC RISK; HERITABILITY; HUMAN; INCIDENCE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; REVIEW; ULCERATIVE COLITIS; X CHROMOSOMAL INHERITANCE;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; INHERITANCE PATTERNS; PREVALENCE; TWIN STUDIES AS TOPIC;

EID: 78650144816     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21385     Document Type: Review

References (22)

1. Orholm M, Munkholm P, Langholz E, et al. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991; 324: 84-88.
2. Irvine EJ, Farrokhyar F, Swarbrick ET,. A critical review of epidemiological studies in inflammatory bowel disease. Scand J Gastroenterol. 2001; 36: 2-15.
3. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008; 40: 955-962.
4. McGovern DP, Gardet A, Torkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 42: 332-337.
5. Tysk C, Lindberg E, Jarnerot G, et al. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut. 1988; 29: 990-996.
6. Halfvarson J, Jess T, Magnuson A, et al. Environmental factors in inflammatory bowel disease: a co-twin control study of a Swedish-Danish twin population. Inflamm Bowel Dis. 2006; 12: 925-933.
7. Thompson NP, Driscoll R, Pounder RE, et al. Genetics versus environment in inflammatory bowel disease: results of a British twin study. BMJ. 1996; 312: 95-96.
8. Orholm M, Binder V, Sorensen TI, et al. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand J Gastroenterol. 2000; 35: 1075-1081.
9. Jess T, Riis L, Jespersgaard C, et al. Disease concordance, zygosity, and NOD2/CARD15 status: follow-up of a population-based cohort of Danish twins with inflammatory bowel disease. Am J Gastroenterol. 2005; 100: 2486-2492.
10. Spehlmann ME, Begun AZ, Burghardt J, et al. Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis. 2008; 14: 968-976.
11. Halfvarson J, Bodin L, Tysk C, et al. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology. 2003; 124: 1767-1773.
12. Halfvarson J,. Genetics in twins with Crohn's disease: less pronounced than previously believed? Inflamm Bowel Dis. Epub ahead of print: 2010; June 1.
13. Economou M, Trikalinos TA, Loizou KT, et al. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol. 2004; 99: 2393-2404.
14. Lockhart-Mummery HE, Morson BC,. Crohn's disease of the large intestine. Gut. 1964; 5: 493-509.
15. Subhani J, Montgomery SM, Pounder RE, et al. Concordance rates of twins and siblings in inflammatory bowel disease. Gastroenterology. 1998: A1093.
16. Halfvarson J, Jess T, Bodin L, et al. Longitudinal concordance for clinical characteristics in a Swedish-Danish twin population with inflammatory bowel disease. Inflamm Bowel Dis. 2007; 13: 1536-1544.
17. Brant SR, Nguyen GC,. Is there a gender difference in the prevalence of Crohn's disease or ulcerative colitis? Inflamm Bowel Dis. 2008; 14 (suppl 2): S2-3.
18. Okazaki T, Wang MH, Rawsthorne P, et al. Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: evidence of gene-gene interactions. Inflamm Bowel Dis. 2008; 14: 1528-1541.
19. Weersma RK, Stokkers PC, Cleynen I, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009; 104: 630-638.
20. Falconer D, Mackay T,. Heritability. Introduction to quantitative genetics, 4th ed. San Francisco: Benjamin Cummings; 1996: 160-183.
21. Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009; 361: 2033-2045.
22. Willing B, Halfvarson J, Dicksved J, et al. Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm Bowel Dis. 2009; 15: 653-660.