Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms

Translational Psychiatry

Volumn 6, Issue , 2016, Pages

  Gonda, X ^a   Eszlari, N ^a   Kovacs, D ^a   Anderson, I M ^b,c   Deakin, J F W ^b,c   Juhasz, G ^a,b,c   Bagdy, G ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; BRIEF SYMPTOM INVENTORY; COMMUNITY SAMPLE; DEPRESSION; DISEASE COURSE; DNA EXTRACTION; FEMALE; FINANCIAL DEFICIT; GENOTYPE; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; TOTAL QUALITY MANAGEMENT; ADOLESCENT; COMPLICATION; DEPRESSIVE DISORDER; GENETIC POLYMORPHISM; GENETICS; HUNGARY; MENTAL STRESS; MIDDLE AGED; PSYCHOLOGY; RISK FACTOR; SOCIOECONOMICS; UNITED KINGDOM; YOUNG ADULT;

ADOLESCENT; DEPRESSIVE DISORDER; FEMALE; HUMANS; HUNGARY; LIFE CHANGE EVENTS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIOECONOMIC FACTORS; STRESS, PSYCHOLOGICAL; UNITED KINGDOM; YOUNG ADULT;

EID: 84966283641     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.57     Document Type: Article

References (83)

1. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
2. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
3. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834.
4. Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 2007; 10: 1103-1109.
5. Murphy SE, Norbury R, Godlewska BR, Cowen PJ, Mannie ZM, Harmer CJ et al. The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis. Mol Psychiatry 2013; 18: 512-520.
6. Gonda X, Fountoulakis KN, Harro J, Pompili M, Akiskal HS, Bagdy G et al. The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality. J Psychopharmacol 2011; 25: 857-866.
7. Gonda X, Fountoulakis KN, Juhasz G, Rihmer Z, Lazary J, Laszik A et al. Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. Eur Arch Psychiatry Clin Neurosci 2009; 259: 106-113.
8. Gonda X, Rihmer Z, Zsombok T, Bagdy G, Akiskal KK, Akiskal HS. The 5HTTLPR polymorphism of the serotonin transporter gene is associated with affective temperaments as measured by TEMPS-A. J Affect Disord 2006; 91: 125-131.
9. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453-460.
10. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 1997; 2: 457-462.
11. Spinelli S, Schwandt ML, Lindell SG, Heilig M, Suomi SJ, Higley JD et al. The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques. Dev Psychopathol 2012; 24: 157-165.
12. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010; 167: 509-527.
13. Munafo MR, Durrant C, Lewis G, Flint J. Gene x environment interactions at the serotonin transporter locus. Biol Psychiatry 2009; 65: 211-219.
14. Risch. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis (vol 301, pg 2462, 2009). JAMA 2009; 302: 492-492.
15. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 2010; 15: 18-22.
16. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited evidence of genetic moderation. Arch Gen Psychiatry 2011; 68: 444-454.
17. Fisher HL, Cohen-Woods S, Hosang GM, Korszun A, Owen M, Craddock N et al. Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder. J Affect Disord 2013; 145: 136-141.
18. Brown GW, Harris TO. Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. J Affect Disord 2008; 111: 1-12.
19. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 2008; 13: 131-146.
20. Grabe HJ, Schwahn C, Mahler J, Schulz A, Spitzer C, Fenske K et al. Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample. Am J Med Genet Part B Neuropsychiat Genet 2012; 159B: 298-309.
21. Sibille E, Lewis DA. SERT-ainly involved in depression, but when? Am J Psychiatry 2006; 163: 8-11.
22. Kobiella A, Reimold M, Ulshofer DE, Ikonomidou VN, Vollmert C, Vollstadt-Klein S et al. How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure. Transl Psychiatry 2011; 1: e37.
23. Lenroot RK, Giedd JN. Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev 2006; 30: 718-729.
24. Shea A, Walsh C, Macmillan H, Steiner M. Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology 2005; 30: 162-178.
25. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 2003; 27: 33-44.
26. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP. Developmental neurobiology of childhood stress and trauma. Psychiatr Clin North Am 2002; 25: 397-426.
27. Drabant EM, Ramel W, Edge MD, Hyde LW, Kuo JR, Goldin PR et al. Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. Am J Psychiatry 2012; 169: 397-405.
28. Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 2008; 63: 852-857.
29. Dannlowski U, Konrad C, Kugel H, Zwitserlood P, Domschke K, Schoning S et al. Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype. Neuroimage 2010; 53: 893-898.
30. Miller R, Wankerl M, Stalder T, Kirschbaum C, Alexander N. The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis. Mol Psychiatry 2013; 18: 1018-1024.
31. Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychol Med 2009; 39: 1425-1432.
32. Cicchetti D, Rogosch FA, Sturge-Apple ML. Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds. Dev Psychopathol 2007; 19: 1161-1180.
33. Juhasz G, Gonda X, Hullam G, Eszlari N, Kovacs D, Lazary J et al. Variability in the effect of 5-HTTLPR on depression in a large European population: the role of age, symptom profile, type and intensity of life stressors. PLoS One 2015; 10: e0116316.
34. Markus CR. Interaction between the 5-HTTLPR genotype, impact of stressful life events, and trait neuroticism on depressive symptoms in healthy volunteers. Psychiatr Genet 2013; 23: 108-116.
35. Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J et al. A prospective cohort study investigating factors associated with depression during medical internship. Arch Gen Psychiatry 2010; 67: 557-565.
36. Lazary J, Lazary A, Gonda X, Benko A, Molnar E, Juhasz G et al. New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype. Biol Psychiatry 2008; 64: 498-504.
37. Sarginson JE, Deakin JFW, Anderson IM, Downey D, Thomas E, Elliott R et al. Neuronal nitric oxide synthase (NOSI) polymorphisms interact with financial hardship to affect depression risk. Neuropsychopharmacology 2014; 39: 2857-2866.
38. Juhasz G, Chase D, Pegg E, Downey D, Toth ZG, Stones K et al. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology 2009; 34: 2019-2027.
39. Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D et al. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry 2011; 69: 762-771.
40. Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychol Med 1983; 13: 595-605.
41. Brugha T, Bebbington P, Tennant C, Hurry J. The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 1985; 15: 189-194.
42. Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW. DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet 2003; 33: 67-72.
43. Field A. Discovering Statistics Using SPSS. Sage Publications: London, UK, 2005.
44. Cicchetti D, Rogosch FA, Oshri A. Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Dev Psychopathol 2011; 23: 1125-1138.
45. Harkness KL, Bagby RM, Stewart JG, Larocque CL, Mazurka R, Strauss JS et al. Childhood emotional and sexual maltreatment moderate the relation of the serotonin transporter gene to stress generation. J Abnormal Psychol 2015; 124: 275-287.
46. Fandino-Losada A, Wei Y, Aberg E, Sjoholm LK, Lavebratt C, Forsell Y. Influence of serotonin transporter promoter variation on the effects of separation from parent/partner on depression. J Affect Disord 2013; 144: 216-224.
47. Walsh ND, Dalgleish T, Dunn VJ, Abbott R St, Clair MC, Owens M et al. 5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents. Neuroimage 2012; 63: 1670-1680.
48. Canli T, Qiu M, Omura K, Congdon E, Haas BW, Amin Z et al. Neural correlates of epigenesis. Proc Natl Acad Sci USA 2006; 103: 16033-16038.
49. Alexander N, Klucken T, Koppe G, Osinsky R, Walter B, Vaitl D et al. Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity. Biol Psychiatry 2012; 72: 49-56.
50. Favaro A, Manara R, Pievani M, Clementi M, Forzan M, Bruson A et al. Neural signatures of the interaction between the 5-HTTLPR genotype and stressful life events in healthy women. Psychiatry Res-Neuroimaging 2014; 223: 157-163.
51. Meltzer H, Bebbington P, Brugha T, Jenkins R, McManus S, Stansfeld S. Job insecurity, socio-economic circumstances and depression. Psychol Med 2010; 40: 1401-1407.
52. van Loo HM, Aggen SH, Gardner CO, Kendler KS. Multiple risk factors predict recurrence of major depressive disorder in women. J Affect Disord 2015; 180: 52-61.
53. Wang YQ, Sareen J, Afifi TO, Bolton SL, Johnson EA, Bolton JM. A population-based longitudinal study of recent stressful life events as risk factors for suicidal behavior in major depressive disorder. Arch Suicide Res 2015; 19: 202-217.
54. Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR∗D: implications for clinical practice. Am J Psychiatry 2006; 163: 28-40.
55. Kendler KS, Gardner CO. Monozygotic twins discordant for major depression: a preliminary exploration of the role of environmental experiences in the aetiology and course of illness. Psychol Med 2001; 31: 411-423.
56. Kendler KS, Walters EE, Kessler RC. The prediction of length of major depressive episodes: results from an epidemiological sample of female twins. Psychol Med 1997; 27: 107-117.
57. Kendler KS, Gardner CO. Sex differences in the pathways to major depression: a study of opposite-sex twin pairs. Am J Psychiatry 2014; 171: 426-435.
58. Kendler KS, Karkowski-Shuman L. Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychol Med 1997; 27: 539-547.
59. Power RA, Wingenbach T, Cohen-Woods S, Uher R, Ng MY, Butler AW et al. Estimating the heritability of reporting stressful life events captured by common genetic variants. Psychol Med 2013; 43: 1965-1971.
60. Sripada RK, Swain JE, Evans GW, Welsh RC, Liberzon I. Childhood poverty and stress reactivity are associated with aberrant functional connectivity in default mode network. Neuropsychopharmacology 2014; 39: 2244-2251.
61. Sjoberg RL, Nilsson KW, Nordquist N, Ohrvik J, Leppert J, Lindstrom L et al. Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 2006; 9: 443-449.
62. Brummett BH, Boyle SH, Siegler IC, Kuhn CM, Ashley-Koch A, Jonassaint CR et al. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav Genet 2008; 38: 34-43.
63. Gressier F, Calati R, Serretti A. 5-HTTLPR and gender differences in affective disorders: a systematic review. J Affect Disord 2016; 190: 193-207.
64. Kurrikoff T, Lehto K, Taht K, Veidebaum T, Harro J. The 5-HTTLPR genotype and depressiveness link: contribution of aspects of environment and gender. Psychiatr Res 2013; 209: 126-127.
65. El-Hage W, Zelaya F, Radua J, Gohier B, Alsop DC, Phillips ML et al. Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype. Neuroimage 2013; 76: 90-97.
66. Volf NV, Belousova LV, Knyazev GG, Kulikov AV. Gender differences in association between serotonin transporter gene polymorphism and resting-state EEG activity. Neuroscience 2015; 284: 513-521.
67. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, DeMontigny C et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 1997; 94: 5308-5313.
68. Costes N, Merlet I, Ostrowsky K, Faillenot I, Lavenne F, Zimmer L et al. A F-18-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. J Nucl Med 2005; 46: 1980-1989.
69. Biver F, Lotstra F, Monclus M, Wikler D, Damhaut P, Mendlewicz J et al. Sex difference in 5HT(2) receptor in the living human brain. Neurosci Lett 1996; 204: 25-28.
70. Brummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC et al. 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet 2008; 38: 476-483.
71. Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ et al. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 2003; 28: 533-541.
72. Jonsson EG, Norton N, Gustavsson JF, Oreland L, Owen MJ, Sedvall GC. A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. J Psychiatr Res 2000; 34: 239-244.
73. Staley JK, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl JP et al. Sex differences in [I-123]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 2001; 41: 275-284.
74. Moreno FA, McGahuey CA, Freeman MP, Delgado PL. Sex differences in depressive response during monoamine depletions in remitted depressive subjects. J Clin Psychiatry 2006; 67: 1618-1623.
75. Jans LAW, Riedel WJ, Markus CR, Blokland A. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 2007; 12: 522-543.
76. Pecins-Thompson M, Brown NA, Bethea CL. Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques. Mol Brain Res 1998; 53: 120-129.
77. Pecins-Thompson M, Bethea CL. Ovarian steroid regulation of serotonin-1 A autoreceptor messenger RNA expression in the dorsal raphe of rhesus macaques. Neuroscience 1999; 89: 267-277.
78. Smith LJ, Henderson JA, Abell CW, Bethea CL. Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques. Neuropsychopharmacology 2004; 29: 2035-2045.
79. Gundlah C, Lu NZ, Bethea CL. Ovarian steroid regulation of monoamine oxidase-A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology 2002; 160: 271-282.
80. Bethea CL, Mirkes SJ, Su A, Michelson D. Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques. Psychoneuroendocrinology 2002; 27: 431-445.
81. Lothe A, Boni C, Costes N, Gorwood P, Bouvard S, Le Bars D et al. Association between triallelic polymorphism of the serotonin transporter and [(18)F] MPPF binding potential at 5-HT(1A) receptors in healthy subjects. Neuroimage 2009; 47: 482-492.
82. Buss DM, Schmitt DP. Sexual Strategies Theory - an Evolutionary Perspective on Human Mating. Psychol Rev 1993; 100: 204-232.
83. Buss DM, Shackelford TK. Human aggression in evolutionary psychological perspective. Clin Psychol Rev 1997; 17: 605-619.