Interaction between the 5-HTTLPR genotype, impact of stressful life events, and trait neuroticism on depressive symptoms in healthy volunteers

Psychiatric Genetics

Volumn 23, Issue 3, 2013, Pages 108-116

  Rob Markus, C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

5 hydroxytryptamine (5 HT) transporter linked polymorphic region; depression symptoms; life events; neuroticism

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; DEPRESSION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; NEUROSIS; PRIORITY JOURNAL; STRESS;

ANXIETY DISORDERS; FEMALE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; REFERENCE VALUES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84876819615     PISSN: 09558829     EISSN: 14735873     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32835fe3e1     Document Type: Article

References (79)

1. Alexander N, Kuepper Y, Schmitz A, Osinsky R, Kozyra E, Hennig J (2009). Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology 34:12941303.
2. Beck AT, Steer RA, Garbin MG (1988). Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev 8:77-100.
3. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961). An inventory for measuring depression. Arch Gen Psychiatry 4:561-571.
4. Brown GW, Bifulco A, Harris TO (1987). Life events, vulnerability and onset of depression: some refinements. Br J Psychiatry 150:30-42.
5. Bukh JD, Bock C, Vinberg M, Werge T, Gether U, Vedel KL (2009). Interaction between genetic polymorphisms and stressful life events in first episode depression. J Affect Disord 119:107-115.
6. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389.
7. Chorbov VM, Lobos EA, Todorov AA, Heath AC, Botteron KN, Todd RD (2007). Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Am J Med Genet B 144B:830-833.
8. Cochrane R, Robertson A (1973). The life events inventory: a measure of the relative severity of psycho-social stressors. J Psychosom Res 17:135-140.
9. Cohen S, Wills TA (1985). Stress, social support, and the buffering hypothesis. Psychol Bull 98:310-357.
10. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D, et al. (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
11. Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillessen AH, Kranzler HR (2007). Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry 61:609-616.
12. Dougherty LR, Klein DN, Congdon E, Canli T, Hayden EP (2010). Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers. Biological Psychology 83:93-100.
13. Dumont M, Provost MA (1999). Resilience in adolescents: protective role of social support, coping strategies, self-esteem, and social activities on experience of stress and depression. J Youth Adolesc 28:343-363.
14. Gallagher DJ (1990). Extraversion, neuroticism and appraisal of stressful academic events. Pers Individ Dif 11:1053-1058.
15. Gillespie NA, Whitfield JB, Williams B, Heath AC, Martin NG (2005). The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med 35:101-111.
16. Glatz K, Mossner R, Heils A, Lesch KP (2003). Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT genepromotor- linked polymorphic region. J Neurochem 86:1072-1078.
17. Gotlib IH, Joormann J, Minor KL, Hallmayer J (2008). HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol Psychiatry 63:847-851.
18. Gough HG (1964). Manual of the California psychological inventory. Palo Alto, CA: Consulting Psychologist Press.
19. Gunthert KC, Cohen LH, Armeli S (1999). The role of neuroticism in daily stress and coping. J Pers Soc Psychol 77:1087-1100.
20. Hammen C (2005). Stress and depression. Annu Rev Clin Psychol 1: 293-319.
21. Hariri AR, Holmes A (2006). Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 10:182-191.
22. Haslam SA, O'Brien A, Jetten J, Vormedal K, Penna S (2005). Taking the strain: social identity, social support, and the experience of stress. Br J Soc Psychol 44:355-370.
23. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
24. Hoefgen B, Schulze TG, Ohlraun S, Von Widdern O, Hofels S, Gross M (2005). The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 57:247-251.
25. Jacobs N, Kenis G, Peeters F, Derom C, Vlietinck R, van Os J (2006). Stressrelated negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 63:989-996.
26. Joiner TE, Johnson F, Soderstrom K, Brown JS (2003). Is there an association between serotonin transporter gene polymorphism and family history of depression? J Affect Disord 77:273-275.
27. Karg K, Burmeister M, Shedden K, Sen S (2011). The serotonin transporter promotor variant (5-HTTLPR), stress and depression meta-analysis revisited. Arch Gen Psychiatry 3:444-454.
28. Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelemter J (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci USA 101: 17316-17321.
29. Kendler KS, Gardner CO, Prescott CA (2003). Personality and the experience of environmental adversity. Psychol Med 33:1193-1202.
30. Kendler KS, Kuhn J, Prescott CA (2004). The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. Am J Psychiatry 161:631-636.
31. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62:529-535.
32. Kessler RC (1997). The effects of stressful life events on depression. Annu Rev Psychol 48:191-214.
33. Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, et al. (2007). The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricaneexposed adults. Am J Psychiatry 164:1693-1699.
34. Kraaij V, Garnefski N, DeWilde EJ, Dijkstra A, Gebhardt W, Maes S, et al. (2003). Negative life events and depressive symptoms in late adolescence: bonding and cognitive coping as vulnerability factors? J Youth Adolesc 32:185-193.
35. Lasa L, Ayuso-Mateos JL, Vazquez-Barquero JL, Diez-Manrique FJ, Dowrick CF (2000). The use of the Beck Depression Inventory to screen for depression in the general population: a preliminary analysis. J Affect Disord 57:261-265.
36. Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT (2005). Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet 133B:110-115.
37. Laucht M, Treutlein J, Schmid B, Blomeyer D, Becker K, Buchmann AF, et al. (2009). Impact of psychosocial adversity on alchohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism. Biol Psychiatry 66:102-109.
38. Lazarus R, Folkman S (1984). Stress, appraisal, and coping. New York: Springer.
39. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
40. Lesch KP, Mossner R (1998). Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44:179-192.
41. Lotrich FE, Pollock BG (2004). Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14:121-129.
42. Luteijn F, Starren J, Van Dijk H (1975). Dutch Personality Questionnaire. Lisse: Swetz en Zeitlinger.
43. Luteijn F, Bouman TK (1988). The concepts of depression, anxiety and neuroticism in questionnaires. Eur J Pers 2:113-120.
44. Maes M, Meltzer H (1995). The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology; the fourth generation of progress. New York: Raven Press. pp. 933-944.
45. Magnus K, Diener E, Fujita F, Pavot W (1993). Extraversion and neuroticism as predictors of objective life events: a longitudinal analysis. J Pers Soc Psychol 65:1046-1053.
46. Markus CR, Capello A (2012). Contribution of the 5-HTTLPR gene by neuroticism on weight gain in male and female subjects. Psychiatr Genet 22:279-285.
47. Markus CR, De Raedt R (2011). Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge. Neuropsychopharmacology 36: 819-826.
48. Markus CR (2008). Dietary amino acids and brain serotonin function; implications for stress-related affective changes. Neuromolecular Med 10:247-258.
49. Middeldorp CM, de Geus EJ, Beem AL, Lakenberg N, Hottenga JJ, Slagboom PE, et al. (2007). Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behav Genet 37:294-301.
50. Mueller A, Brocke B, Fries E, Lesch KP, Kirschbaum C (2010). The role of the serotonin transporter polymorphism for the endocrine stress response in newborns. Psychoneuroendocrinology 35:289-296.
51. Munafo MR, Clark TG, Moore LR, Payne E, Walton R, Flint J (2003). Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatry 8:471-484.
52. Munafo MR, Clark T, Flint J (2005). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 10:415-419.
53. Munafo MR, Brown SM, Hariri AR (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63: 852-857.
54. Nakamura M, Ueno S, Sano A, Tanabe H (2000). The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5:32-38.
55. Neumeister A, Hu XZ, Luckenbaugh DA, Schwarz M, Nugent AC, Bonne O, et al. (2006). Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 63:978-986.
56. Paykel ES (2003). Life events and affective disorders. Acta Psychiatrica Scandinavia 108 (Suppl):61-66.
57. Penley JA, Tomaka J (2002). Associations among the big five, emotional responses, and coping with acute stress. Pers Individ Dif 32:1215-1228.
58. Power T, Stewart R, Ancelin ML, Jaussent I (2008). 5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population. Neurobiol Aging 79:979-984.
59. Roberts SB, Kendler KS (1999). Neuroticism and self-esteem as indices of the vulnerability to major depression in women. Psychol Med 29: 1101-1109.
60. Roesch SC, Wee C, Vaughn AA (2006). Relations between the big five personality traits and dispositional coping in Korean Americans: acculturation as a moderating factor. Int J Psychol 41:85-96.
61. Schinka JA, Busch RM, Robichaux-Keene N (2004). A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and train anxiety. Mol Psychiatry 9:197-202.
62. Schwarzer R, Knoll N (2007). Functional roles of social support within the stress and coping process: a theoretical and empirical overview. In J Psychol 42:243-253.
63. Sen S, Burmeister M, Ghosh D (2004). Meta-analysis of the association between a serotonin transporter polymorphism (5-HTTLPR) and anxietyrelated personality traits. Am J Med Genet B Neuropsychiatr Genet 127: 85-89.
64. Sheikh HI, Hayden EP, Singh SM, Dougherty LR, Olino TM, Durbin CE, Klein DN (2008). An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood. Pers Individ Dif 45:425-428.
65. Shoji K, Harrigan JA, Woll SB, Miller SA (2009). Interactions among situations, neuroticism, and appraisals in coping strategy choice. Pers Individ Dif 48:270-276.
66. Taylor SE, Way BM, Welch WT, Hilmert CJ, Lehman BJ, Eisenberger NI (2006). Early family environment, current adversity, the serotonin transporter polymorphism, and depressive symptomatology. Biol Psychiatry 60: 671-676.
67. Tennant C (2002). Life events, stress and depression: a review of the findings. Aust N Z J Psychiatry 361:173-182.
68. Thoits PA (1995). Stress, coping, and social support processes: where are we? What next? J Health Soc Behav 35:53-79.
69. Uher R, McGuffin P (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 13:131-146.
70. Uher R, McGuffin P (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 15:18-22.
71. Valentiner DP, Holahan CJ, Moos RH (1994). Social support, appraisals of event controllability, and coping: an integrative model. J Pers Soc Psychol 66:1094-1102.
72. Van Praag HM (2004). Can stress cause depression? Prog Neuropsychopharmacol Biol Psych 28:891-907.
73. Verschoor E, Markus CR (2011). Affective and neuroendocrine stress reactivity to an academic examination: influences of the 5-HTTLPR genotype and trait neuroticism. Biol Psychol 87:439-449.
74. Walderhaug E, Magnusson A, Neumeister A, Lappalainen J, Lunde H, Refsum H, Landro NI (2007). Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol Psychiatry 62:593-599.
75. Watson D, Clark LA (1984). Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull 96:465-490.
76. Way BM, Taylor SE (2010). The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biol Psychiatry 67:487-492.
77. Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms NJ, et al. (2003). Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 28:533-541.
78. Willis-Owen SA, Turri MG, Munafo MR, Surtees PG,Wainwright NW, Brixey RD, et al. (2005). The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry 58:451-456.
79. Zalsman G, Huang YY, Oquendo MA, Burke AK, Hu X, Brent DA, et al. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163:1588-1593.