Childhood emotional and sexual maltreatment moderate the relation of the serotonin transporter gene to stress generation

Journal of Abnormal Psychology

Volumn 124, Issue 2, 2015, Pages 275-287

  Harkness, Kate L ^a   Michael Bagby, R ^b   Stewart, Jeremy G ^a,d   Larocque, Cherie L ^a   Mazurka, Raegan ^a   Strauss, John S ^b   Ravindran, Arun ^b   Rector, Neil A ^b   Wynne Edwards, Katherine E ^c   Kennedy, James L ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Child maltreatment; Depression; Serotonin transporter gene; Stress generation; Stressful life events

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILDHOOD MALTREATMENT; COMMUNITY SAMPLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA POLYMORPHISM; EMOTIONAL ABUSE; ENVIRONMENTAL FACTOR; FEMALE; GENE; HEREDITY; HOMOZYGOSITY; HUMAN; INTERVIEW; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; POLYMORPHIC LOCUS; PROMOTER REGION; SEROTONIN TRANSPORTER GENE; SEXUAL ABUSE; SOCIAL PROBLEM; STRESS; CHILD; CHILD ABUSE; CHILD ABUSE SURVIVOR; ETIOLOGY; GENETICS; MENTAL STRESS; YOUNG ADULT;

ADOLESCENT; ADULT; ADULT SURVIVORS OF CHILD ABUSE; CHILD; CHILD ABUSE; FEMALE; HUMANS; LIFE CHANGE EVENTS; MALE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84929508702     PISSN: 0021843X     EISSN: 19391846     Source Type: Journal    
DOI: 10.1037/abn0000034     Document Type: Article

References (85)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (Vol. 4). Washington, DC: Author.
2. Antypa, N., & Van der Does, A. J. W. (2010). Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression. Genes, Brain & Behavior, 9, 615-620.
3. Beck, A. T. (1996). Beck Depression Inventory (2nd ed.). San Antonio, TX: Psychological Corporation.
4. Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. The American Journal of Psychiatry, 165, 969-977. http://dx.doi.org/10.1176/appi.ajp.2008.08050721
5. Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B. Methodological, 85, 289-300.
6. Bergen, S. E., Gardner, C. O., & Kendler, K. S. (2007). Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: A meta-analysis. Twin Research and Human Genetics, 10, 423-433. http://dx.doi.org/10.1375/twin.10.3.423
7. Bifulco, A., Brown, G., Edwards, A., Harris, T., Neilson, E., Richards, C., & Robinson, R. (1989). Life Events and Difficulties Schedule (LEDS-2). Vol. 1: Life events manual. London: Royal Halloway and Bedford New College, University of London.
8. Bifulco, A. T., Brown, G. W., & Harris, T. O. (1987). Childhood loss of parent, lack of adequate parental care and adult depression: A replication. Journal of Affective Disorders, 12, 115-128. http://dx.doi.org/10.1016/0165-0327(87)90003-6
9. Bifulco, A., Brown, G. W., & Harris, T. O. (1994). Childhood Experience of Care and Abuse (CECA): A retrospective interview measure. Child Psychology and Psychiatry, and Allied Disciplines, 35, 1419-1435. http://dx.doi.org/10.1111/j.1469-7610.1994.tb01284.x
10. Brown, G. W., Craig, T. K., Harris, T. O., Handley, R. V., & Harvey, A. L. (2007). Validity of retrospective measures of early maltreatment and depressive episodes using the Childhood Experience of Care and Abuse (CECA) instrument-A life-course study of adult chronic depression-2. Journal of Affective Disorders, 103, 217-224. http://dx.doi.org/10.1016/j.jad.2007.06.003
11. Brown, G. W., & Harris, T. O. (1989). Depression. In G. W. Brown & T. O. Harris (Eds.), Life events and illness (pp. 49-93). New York, NY: Guilford Press.
12. Brown, T. A., & Rosellini, A. J. (2011). The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. Journal of Abnormal Psychology, 120, 844-856. http://dx.doi.org/10.1037/a0023035
13. Canli, T., & Lesch, K.-P. (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience, 10, 1103-1109. http://dx.doi.org/10.1038/nn1964
14. Caspers, K. M., Paradiso, S., Yucuis, R., Troutman, B., Arndt, S., & Philibert, R. (2009). Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment. Developmental Psychology, 45, 64-76. http://dx.doi.org/10.1037/a0014026
15. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. The American Journal of Psychiatry, 167, 509-527. http://dx.doi.org/10.1176/appi.ajp.2010.09101452
16. Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2011). The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. Development and Psychopathology, 23, 357-372. http://dx.doi.org/10.1017/S0954579411000113
17. Cicchetti, D., & Toth, S. L. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409-438. http://dx.doi.org/10.1146/annurev .clinpsy.1.102803.144029
18. Conway, M., Mendelson, M., Giannopoulos, C., Csank, P. A. R., & Holm, S. L. (2004). Childhood and adult sexual abuse, rumination on sadness, and dysphoria. Child Abuse & Neglect, 28, 393-410. http://dx.doi.org/10.1016/j.chiabu.2003.05.004
19. DiCiccio, T. J., & Efron, B. (1996). Bootstrap confidence intervals (with Discussion). Statistical Science, 11, 189-228. http://dx.doi.org/10.1214/ss/1032280214
20. DiLillo, D. (2001). Interpersonal functioning among women reporting a history of childhood sexual abuse: Empirical findings and methodological issues. Clinical Psychology Review, 21, 553-576. http://dx.doi.org/10.1016/S0272-7358(99)00072-0
21. Dozois, D. J. A., Dobson, K. S., & Ahnberg, J. L. (1998). A psychometric evaluation of the Beck Depression Inventory-II. Psychological Assessment, 10, 83-89. http://dx.doi.org/10.1037/1040-3590.10.2.83
22. Dube, S. R., Williamson, D. F., Thompson, T., Felitti, V. J., & Anda, R. F. (2004). Assessing the reliability of retrospective reports of adverse childhood experiences among adult HMO members attending a primary care clinic. Child Abuse & Neglect, 28, 729-737. http://dx.doi.org/10.1016/j.chiabu.2003.08.009
23. Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. The American Journal of Psychiatry, 168, 1041-1049. http://dx.doi .org/10.1176/appi.ajp.2011.11020191
24. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (2002). Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient ed. (SCID-I/P). New York, NY: Biometrics Research.
25. Flynn, M., Kecmanovic, J., & Alloy, L. B. (2010). An examination of integrated cognitive-interpersonal vulnerability to depression: The role of rumination, perceived social support, and interpersonal stress generation. Cognitive Therapy and Research, 34, 456-466. http://dx.doi.org/10.1007/s10608-010-9300-8
26. Frank, E., Matty, M. K., & Anderson, B. (1997). Interview schedule for life-events and difficulties, adolescent version (Pittsburgh). Pittsburgh, PA: University of Pittsburgh Medical School.
27. Gibb, B. E., Uhrlass, D. J., Grassia, M., Benas, J. S., & McGeary, J. (2009). Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression. Journal of Abnormal Psychology, 118, 734-745. http://dx.doi.org/10.1037/a0016765
28. Grabe, H. J., Schwahn, C., Mahler, J., Appel, K., Schulz, A., Spitzer, C., . . . Völzke, H. (2012). Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 36, 264-270. http://dx.doi.org/10.1016/j.pnpbp.2011.09.010
29. Greenberg, B. D., Tolliver, T. J., Huang, S. J., Li, Q., Bengel, D., & Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics, 88, 83-87. http://dx.doi.org/10.1002/(SICI)1096-8628(19990205)88:1_83::AID-AJMG15_3.0.CO;2-0
30. Grove, W. M., Andreasen, N. C., McDonald-Scott, P., Keller, M. B., & Shapiro, R. W. (1981). Reliability studies of psychiatric diagnosis. Theory and practice. Archives of General Psychiatry, 38, 408-413. http://dx.doi.org/10.1001/archpsyc.1981.01780290042004
31. Hamilton, J. L., Stange, J. P., Kleiman, E. M., Hamlat, E. J., Abramson, L. Y., & Alloy, L. B. (2014). Cognitive vulnerabilities amplify the effect of early pubertal timing on interpersonal stress generation during adolescence. Journal of Youth and Adolescence, 43, 824-833.
32. Hammen, C. (1991). Generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555-561. http://dx.doi.org/10.1037/0021-843X.100.4.555
33. Hammen, C. (2006). Stress generation in depression: Reflections on origins, research, and future directions. Journal of Clinical Psychology, 62, 1065-1082. http://dx.doi.org/10.1002/jclp.20293
34. Hammen, C., Brennan, P. A., & Le Brocque, R. (2011). Youth depression and early childrearing: Stress generation and intergenerational transmission of depression. Journal of Consulting and Clinical Psychology, 79, 353-363. http://dx.doi.org/10.1037/a0023536
35. Hammen, C., Henry, R., & Daley, S. E. (2000). Depression and sensitization to stressors among young women as a function of childhood adversity. Journal of Consulting and Clinical Psychology, 68, 782-787. http://dx.doi.org/10.1037/0022-006X.68.5.782
36. Hankin, B. L. (2005). Childhood maltreatment and psychopathology: Prospective tests of attachment, cognitive vulnerability, and stress as mediating processes. Cognitive Therapy and Research, 29, 645-671. http://dx.doi.org/10.1007/s10608-005-9631-z
37. Hankin, B. L., Stone, L., & Wright, P. A. (2010). Corumination, interpersonal stress generation, and internalizing symptoms: Accumulating effects and transactional influences in a multiwave study of adolescents. Development and Psychopathology, 22, 217-235. http://dx.doi.org/10.1017/S0954579409990368
38. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146-152. http://dx.doi.org/10.1001/archpsyc.62.2.146
39. Harkness, K. L., Bagby, R. M., & Kennedy, S. (2012). Childhood maltreatment and differential treatment response and recurrence in adult major depressive disorder. Journal of Consulting and Clinical Psychology, 80, 342-353. http://dx.doi.org/10.1037/a0027665
40. Harkness, K. L., & Lumley, M. N. (2007). Child abuse and neglect and the development of depression in children and adolescents. In J. Abela & B. Hankin (Eds.), Depression in children and adolescents (pp. 639-657). New York, NY: Guilford Press.
41. Harkness, K. L., Lumley, M. N., & Truss, A. E. (2008). Stress generation in adolescent depression: The moderating role of child abuse and neglect. Journal of Abnormal Child Psychology, 36, 421-432. http://dx .doi.org/10.1007/s10802-007-9188-2
42. Harkness, K. L., & Monroe, S. M. (2002). Childhood adversity and the endogenous versus nonendogenous distinction in women with major depression. The American Journal of Psychiatry, 159, 387-393. http://dx.doi.org/10.1176/appi.ajp.159.3.387
43. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624. http://dx .doi.org/10.1046/j.1471-4159.1996.66062621.x
44. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression metaanalysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454. http://dx.doi.org/10.1001/archgenpsychiatry .2010.189
45. Kaufman, J., Birmaher, B., Brent, D., Rao, U., & Ryan, N. (1996). Kiddie-Sads-Present and lifetime version (K-SADS-PL). Pittsburgh, PA: University of Pittsburgh Medical School.
46. Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999). Causal relationship between stressful life events and the onset of major depression. The American Journal of Psychiatry, 156, 837-841.
47. Kendler, K. S., & Karkowski-Shuman, L. (1997). Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment? Psychological Medicine, 27, 539-547. http://dx.doi.org/10.1017/S0033291797004716
48. Kercher, A. J., Rapee, R. M., & Schniering, C. A. (2009). Neuroticism, life events and negative thoughts in the development of depression in adolescent girls. Journal of Abnormal Child Psychology, 37, 903-915. http://dx.doi.org/10.1007/s10802-009-9325-1
49. Lahiri, D. K., & Nurnberger, J. I., Jr. (1991). A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research, 19, 5444. http://dx.doi.org/10.1093/nar/19.19.5444
50. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., . . . Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531. http://dx.doi.org/10.1126/science.274.5292.1527
51. Lesch, K.-P., & Waider, J. (2012). Serotonin in the modulation of neural plasticity and networks: Implications for neurodevelopmental disorders. Neuron, 76, 175-191. http://dx.doi.org/10.1016/j.neuron.2012.09.013
52. Liu, R. T., & Alloy, L. B. (2010). Stress generation in depression: A systematic review of the empirical literature and recommendations for future study. Clinical Psychology Review, 30, 582-593. http://dx.doi .org/10.1016/j.cpr.2010.04.010
53. Liu, R. T., Choi, J. Y., Boland, E. M., Mastin, B. M., & Alloy, L. B. (2013). Childhood abuse and stress generation: The mediational effect of depressogenic cognitive styles. Psychiatry Research, 206, 217-222. http://dx.doi.org/10.1016/j.psychres.2012.12.001.
54. Lumley, M. N., & Harkness, K. L. (2009). Childhood maltreatment and depressotypic cognitive organization. Cognitive Therapy and Research, 33, 511-522. http://dx.doi.org/10.1007/s10608-009-9257-7
55. Lyubomirsky, S., & Nolen-Hoeksema, S. (1995). Effects of self-focused rumination on negative thinking and interpersonal problem solving. Journal of Personality and Social Psychology, 69, 176-190. http://dx .doi.org/10.1037/0022-3514.69.1.176
56. MacMillan, H. L., Fleming, J. E., Streiner, D. L., Lin, E., Boyle, M. H., Jamieson, E., . . . Beardslee, W. R. (2001). Childhood abuse and lifetime psychopathology in a community sample. The American Journal of Psychiatry, 158, 1878-1883. http://dx.doi.org/10.1176/appi.ajp.158.11.1878
57. McGee, R. A., Wolfe, D. A., Yuen, S. A., Wilson, S. K., & Carnochan, J. (1995). The measurement of maltreatment: A comparison of approaches. Child Abuse & Neglect, 19, 233-249. http://dx.doi.org/10.1016/0145-2134(94)00119-F
58. McLaughlin, K. A., & Nolen-Hoeksema, S. (2012). Interpersonal stress generation as a mechanism linking rumination to internalizing symptoms in early adolescents. Journal of Clinical Child and Adolescent Psychology, 41, 584-597. http://dx.doi.org/10.1080/15374416.2012.704840
59. Monaghan, P. (2008). Early growth conditions, phenotypic development and environmental change. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 363, 1635-1645. http://dx.doi.org/10.1098/rstb.2007.0011
60. Monroe, S. M. (2008). Modern approaches to conceptualizing and measuring human life stress. Annual Review of Clinical Psychology, 4, 33-52. http://dx.doi.org/10.1146/annurev.clinpsy.4.022007.141207
61. Monroe, S. M., & Reid, M. W. (2008). Gene-environment interactions in depression research: Genetic polymorphisms and life-stress polyprocedures. Psychological Science, 19, 947-956. http://dx.doi.org/10.1111/j .1467-9280.2008.02181.x
62. Monroe, S. M., Rohde, P., Seeley, J. R., & Lewinsohn, P. M. (1999). Life events and depression in adolescence: Relationship loss as a prospective risk factor for first onset of major depressive disorder. Journal of Abnormal Psychology, 108, 606-614. http://dx.doi.org/10.1037/0021-843X.108.4.606
63. Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406-425. http://dx.doi.org/10.1037/0033-2909.110.3.406
64. Moretti, M. M., & Craig, S. G. (2013). Maternal versus paternal physical and emotional abuse, affect regulation and risk for depression from adolescence to early adulthood. Child Abuse & Neglect, 37, 4-13. http://dx.doi.org/10.1016/j.chiabu.2012.09.015
65. Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852-857. http://dx.doi.org/10.1016/j.biopsych .2007.08.016
66. Nanni, V., Uher, R., & Danese, A. (2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: A meta-analysis. The American Journal of Psychiatry, 169, 141-151. http://dx.doi.org/10.1176/appi.ajp.2011.11020335
67. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., . . . Weinberger, D. R. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828-834. http://dx.doi.org/10.1038/nn1463
68. Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309-322. http://dx.doi.org/10.1037/0033-2909.84.2.309
69. Praschak-Rieder, N., Kennedy, J., Wilson, A. A., Hussey, D., Boovariwala, A., Willeit, M., . . . Meyer, J. H. (2007). Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: A [(11)C] DASB positron emission tomography study. Biological Psychiatry, 62, 327-331. http://dx.doi.org/10.1016/j.biopsych.2006.09.022
70. Raes, F., & Hermans, D. (2008). On the mediating role of subtypes of rumination in the relationship between childhood emotional abuse and depressed mood: Brooding vs. reflection. Depression and Anxiety, 25, 1067-1070.
71. Reiner, I., & Spangler, G. (2010). Adult attachment and gene polymorphisms of the dopamine D4 receptor and serotonin transporter (5-HTT). Attachment & Human Development, 12, 209-229. http://dx.doi.org/10.1080/14616731003759674
72. Rich, C. L., Gidycz, C. A., Warkentin, J. B., Loh, C., & Weiland, P. (2005). Child and adolescent abuse and subsequent victimization: A prospective study. Child Abuse & Neglect, 29, 1373-1394. http://dx.doi.org/10.1016/j.chiabu.2005.07.003
73. Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., . . . Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA: Journal of the American Medical Association, 301, 2462-2471. http://dx.doi.org/10.1001/jama.2009.878
74. Rosenthal, N. L., & Kobak, R. (2010). Assessing adolescents' attachment hierarchies: Differences across developmental periods and associations with individual adaptation. Journal of Research on Adolescence, 20, 678-706. http://dx.doi.org/10.1111/j.1532-7795.2010.00655.x
75. Scarr, S., & McCartney, K. (1983). How people make their own environments: A theory of genotype greater than environment effects. Child Development, 54, 424-435.
76. Shapero, B. G., Hankin, B. L., & Barrocas, A. L. (2013). Stress generation and exposure in a multi-wave study of adolescents: Transactional processes and sex differences. Journal of Social and Clinical Psychology, 32, 989-1012. http://dx.doi.org/10.1521/jscp.2013.32.9.989
77. Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002). Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry, 51, 693-707. http://dx.doi .org/10.1016/S0006-3223(02)01314-8
78. Spasojević, J., & Alloy, L. B. (2002). Who Becomes a Depressive Ruminator? Developmental Antecedents of Ruminative Response Style. Journal of Cognitive Psychotherapy, 16, 405-419. http://dx.doi.org/10.1891/088983902780935713
79. Starr, L. R., Hammen, C., Brennan, P. A., & Najman, J. M. (2012). Serotonin transporter gene as a predictor of stress generation in depression. Journal of Abnormal Psychology, 121, 810-818. http://dx.doi.org/10.1037/a0027952
80. Starr, L. R., Hammen, C., Brennan, P. A., & Najman, J. M. (2013). Relational security moderates the effect of serotonin transporter gene polymorphism (5-HTTLPR) on stress generation and depression among adolescents. Journal of Abnormal Child Psychology, 41, 379-388. http://dx.doi.org/10.1007/s10802-012-9682-z
81. Storey, J. D. (2002). A direct approach to false discovery rates. Journal of the Royal Statistical Society Series B. Methodological, 64, 479-498. http://dx.doi.org/10.1111/1467-9868.00346
82. Uher, R., & McGuffin, P. (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18-22. http://dx.doi.org/10.1038/mp.2009.123
83. Uhrlass, D. J., & Gibb, B. E. (2007). Childhood emotional maltreatment and the stress generation model of depression. Journal of Social and Clinical Psychology, 26, 119-130. http://dx.doi.org/10.1521/jscp.2007.26.1.119
84. Uliaszek, A. A., Zinbarg, R. E., Mineka, S., Craske, M. G., Griffith, J. W., Sutton, J. M., . . . Hammen, C. (2012). A longitudinal examination of stress generation in depressive and anxiety disorders. Journal of Abnormal Psychology, 121, 4-15. http://dx.doi.org/10.1037/a0025835
85. Zalsman, G., Huang, Y. Y., Oquendo, M. A., Burke, A. K., Hu, X. Z., Brent, D. A., . . . Mann, J. J. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. The American Journal of Psychiatry, 163, 1588-1593. http://dx.doi.org/10.1176/appi.ajp.163.9.1588