Antibiotic treatment enhances the genome-wide mutation rate of target cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 18, 2016, Pages E2498-E2505

  Long, Hongan ^a   Miller, Samuel F ^a   Strauss, Chloe ^a   Zhao, Chaoxian ^b   Cheng, Lei ^c   Ye, Zhiqiang ^a   Griffin, Katherine ^a   Te, Ronald ^a   Lee, Heewook ^d   Chen, Chi Chun ^a   Lynch, Michael ^a  

^a INDIANA UNIVERSITY   (United States)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c SOUTH CHINA SEA FISHERIES RESEARCH INSTITUTE   (China)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; DNA repair; Low fidelity polymerases; Mutation rate; Resistance evolution

Indexed keywords

DNA; DNA POLYMERASE; NORFLOXACIN; ANTIINFECTIVE AGENT;

ADAPTATION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; MISMATCH REPAIR; MUTAGENESIS; MUTATION ACCUMULATION; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TARGET CELL; BACTERIAL GENOME; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GENOMIC INSTABILITY; MOLECULAR EVOLUTION; MUTATION;

ANTI-BACTERIAL AGENTS; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; GENOMIC INSTABILITY; MUTAGENESIS; MUTATION; NORFLOXACIN;

EID: 84965115108     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601208113     Document Type: Article

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