The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function

Neurobiology of Aging

Volumn 43, Issue , 2016, Pages 140-148

  Costello, Derek A ^a,b   Keenan, Kathryn ^a   McManus, Róisín M ^a   Falvey, Aidan ^a   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Age; Bone marrow derived macrophages; Inflammatory cytokines; Microglia; Synaptic plasticity

Indexed keywords

BRAIN EXTRACT; CD40 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE;

ADULT; AGING; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW DERIVED MACROPHAGE; BRAIN SLICE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLIA CELL; HIPPOCAMPUS; LONG TERM POTENTIATION; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SYNAPSE; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; IMMUNOLOGY; MACROPHAGE; METABOLISM; NERVE CELL PLASTICITY; PATHOLOGY; PHYSIOLOGY;

AGING; ANIMALS; BRAIN; CELLS, CULTURED; CYTOKINES; INFLAMMATION MEDIATORS; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE, INBRED C57BL; NEURONAL PLASTICITY; SYNAPSES;

EID: 84965037035     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.04.001     Document Type: Article

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