Self-assembled micelle interfering RNA for effective and safe targeting of dysregulated genes in pulmonary fibrosis

Journal of Biological Chemistry

Volumn 291, Issue 12, 2016, Pages 6433-6446

  Yoon, Pyoung Oh ^a   Park, Jin Wook ^b   Lee, Chang Min ^b   Kim, Sung Hwan ^d   Kim, Han Na ^a   Ko, Youngho ^a   Bae, Seon Joo ^a   Yun, Sungil ^a   Park, Jun Hong ^a   Kwon, Taewoo ^a   Kim, Woo Seok ^a   Lee, Jiyoung ^a   Lu, Qing ^c   Kang, Hye Ryun ^e   Cho, Won Kyung ^c   Elias, Jack A ^b   Yang, Joo Sung ^a   Park, Han Oh ^a   Lee, Kyuhong ^d   Lee, Chun Geun ^b  

^a Bioneer Corporation   (South Korea)

^b BROWN UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

^d Korea Institute of Toxicology   (South Korea)

^e Seoul National University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BIOLOGICAL ORGANS; COLLAGEN; GENES; LIPOSOMES; MICELLES; MUSCULOSKELETAL SYSTEM; NANOPARTICLES; PEPTIDES; RNA; TISSUE;

COLLAGEN ACCUMULATION; CONNECTIVE TISSUE GROWTH FACTOR; HYDROPHILIC POLYMERS; PERIPHERAL BLOOD MONONUCLEAR CELLS; POLYDISPERSITY INDICES; PULMONARY FIBROSIS; THERAPEUTIC APPLICATION; TRANSGENIC ANIMALS;

GENE EXPRESSION;

AMPHIREGULIN; BLEOMYCIN; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; INTERLEUKIN 12; INTERLEUKIN 6; LIPOSOME; NANOPARTICLE; SELF ASSEMBLED MICELLE INTERFERING RNA; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AREG PROTEIN, MOUSE; CTGF PROTEIN, MOUSE; EPIDERMAL GROWTH FACTOR DERIVATIVE; MICELLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE SILENCING; GENE TARGETING; IN VIVO STUDY; INNATE IMMUNITY; LUNG FIBROSIS; LUNG FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY TESTING; ANIMAL; C57BL MOUSE; CELL CULTURE; FEMALE; GENE THERAPY; GENETICS; LUNG; METABOLISM; MICELLE; PATHOLOGY; PROCEDURES; PULMONARY FIBROSIS; RNA INTERFERENCE; TISSUE DISTRIBUTION;

AMPHIREGULIN; ANIMALS; CELLS, CULTURED; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; EGF FAMILY OF PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENETIC THERAPY; LUNG; MALE; MICE, INBRED C57BL; MICELLES; NANOPARTICLES; PULMONARY FIBROSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84964883876     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.693671     Document Type: Article

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