-
1
-
-
0346728473
-
Systematic genome-wide screens of gene function
-
Carpenter, A. E.; Sabatini, D. M. Systematic genome-wide screens of gene function Nat. Rev. Gen. 2004, 5, 11-22
-
(2004)
Nat. Rev. Gen.
, vol.5
, pp. 11-22
-
-
Carpenter, A.E.1
Sabatini, D.M.2
-
2
-
-
62149124046
-
Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interference
-
Fortunato, A. Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interference Genomics 2009, 93, 392-396
-
(2009)
Genomics
, vol.93
, pp. 392-396
-
-
Fortunato, A.1
-
3
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A.; Xu, S.; Montgomery, M. K.; Kostas, S. A.; Driver, S. E.; Mello, C. C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 1998, 391, 806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
4
-
-
0033789992
-
Specific interference with gene function by double-stranded RNA in early mouse development
-
Wianny, F.; Zernicka-Goetz, M. Specific interference with gene function by double-stranded RNA in early mouse development Nat. Cell Biol. 2000, 2, 70-75
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 70-75
-
-
Wianny, F.1
Zernicka-Goetz, M.2
-
5
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S. M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 2001, 411, 494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
6
-
-
33845370280
-
RNA polymerase III transcribes human microRNAs
-
Borchert, G. M.; Lanier, W.; Davidson, B. L. RNA polymerase III transcribes human microRNAs Nat. Struct. Mol. Biol. 2006, 13, 1097-1101
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 1097-1101
-
-
Borchert, G.M.1
Lanier, W.2
Davidson, B.L.3
-
7
-
-
10944254152
-
Trascription and processing of human microRNA precursors
-
Cullen, B. R. Trascription and processing of human microRNA precursors Mol. Cell 2004, 16, 861-865
-
(2004)
Mol. Cell
, vol.16
, pp. 861-865
-
-
Cullen, B.R.1
-
8
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore, P. D.; Tuschl, T.; Sharp, P. A.; Bartel, P. D. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals Cell 2000, 101, 25-33
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, P.D.4
-
9
-
-
0035798415
-
ATP requirements and small interfering RNA structure in the RNA interference pathway
-
Nykanen, A.; Haley, B.; Zamore, P. D. ATP requirements and small interfering RNA structure in the RNA interference pathway Cell 2001, 107, 301-321
-
(2001)
Cell
, vol.107
, pp. 301-321
-
-
Nykanen, A.1
Haley, B.2
Zamore, P.D.3
-
10
-
-
84868589615
-
Biology of PIWI-interacting RNAs: New insights into biogenesis and function inside and outside of germlines
-
Ishizu, H.; Siomi, H.; Siomi, M. C. Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines Genes Dev. 2012, 26 (21) 2361-2373
-
(2012)
Genes Dev.
, vol.26
, Issue.21
, pp. 2361-2373
-
-
Ishizu, H.1
Siomi, H.2
Siomi, M.C.3
-
11
-
-
34248682403
-
RNAi therapeutics: Principles, prospects and challenges
-
Aagaard, L.; Rossi, J. J. RNAi therapeutics: principles, prospects and challenges Adv. Drug Delivery Rev 2007, 59, 75-86
-
(2007)
Adv. Drug Delivery Rev
, vol.59
, pp. 75-86
-
-
Aagaard, L.1
Rossi, J.J.2
-
12
-
-
79954580272
-
Current prospects for RNA interference-based therapies
-
Davidson, B. L.; McCray, P. B., Jr. Current prospects for RNA interference-based therapies Nat. Rev. Genet. 2011, 12, 329-340
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 329-340
-
-
Davidson, B.L.1
McCray Jr., P.B.2
-
13
-
-
80052627990
-
Current progress of siRNA/shRNA therapeutics in clinical trials
-
Burnett, J. C.; Rossi, J. J.; Tiemann, K. Current progress of siRNA/shRNA therapeutics in clinical trials Biotechnol. J. 2011, 6, 1130-1146
-
(2011)
Biotechnol. J.
, vol.6
, pp. 1130-1146
-
-
Burnett, J.C.1
Rossi, J.J.2
Tiemann, K.3
-
14
-
-
84859269808
-
Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design
-
Buyens, K.; De Smedt, S. C.; Braeckmans, K.; Demeester, J.; Peeters, L.; van Grunsven, L. A.; de Mollerat du Jeu, X.; Sawant, R.; Torchilin, V.; Farkasova, K.; Ogris, M.; Sanders, N. N. Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design J. Controlled Release 2012, 158, 362-370
-
(2012)
J. Controlled Release
, vol.158
, pp. 362-370
-
-
Buyens, K.1
De Smedt, S.C.2
Braeckmans, K.3
Demeester, J.4
Peeters, L.5
Van Grunsven, L.A.6
De Mollerat Du Jeu, X.7
Sawant, R.8
Torchilin, V.9
Farkasova, K.10
Ogris, M.11
Sanders, N.N.12
-
15
-
-
78649505850
-
Medicinal chemistry of siRNA delivery
-
Stanton, M. G.; Colletti, S. L. Medicinal chemistry of siRNA delivery J. Med. Chem. 2010, 53, 7887-7901
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7887-7901
-
-
Stanton, M.G.1
Colletti, S.L.2
-
16
-
-
84875341955
-
Viral and nonviral delivery systems for gene delivery
-
Nayerossadat, N.; Maedeh, T.; Ali, P. A. Viral and nonviral delivery systems for gene delivery Adv Biomed. Res. 2012, 1, 27
-
(2012)
Adv Biomed. Res.
, vol.1
, pp. 27
-
-
Nayerossadat, N.1
Maedeh, T.2
Ali, P.A.3
-
17
-
-
0022486185
-
Lipid polymorphism and the role of lipid in membranes
-
Cullis, P. R.; Hope, M. J.; Tilcock, C. P. Lipid polymorphism and the role of lipid in membranes Chem. Phys. Lipids 1986, 40, 127-144
-
(1986)
Chem. Phys. Lipids
, vol.40
, pp. 127-144
-
-
Cullis, P.R.1
Hope, M.J.2
Tilcock, C.P.3
-
19
-
-
84862804633
-
Polymeric micelles drug delivery systems in oncology
-
Gong, J.; Chen, M.; Zheng, Y.; Wang, S.; Wang, Y. Polymeric micelles drug delivery systems in oncology J. Controlled Release 2012, 159, 312-323
-
(2012)
J. Controlled Release
, vol.159
, pp. 312-323
-
-
Gong, J.1
Chen, M.2
Zheng, Y.3
Wang, S.4
Wang, Y.5
-
20
-
-
0035815009
-
Interaction of DNA with cationic micelles: Effects of micelle surface charge density, micelle shape, and ionic strength on complexation and DNA collapse
-
Wang, Y.; Dubin, P. L.; Zhang, H. Interaction of DNA with cationic micelles: effects of micelle surface charge density, micelle shape, and ionic strength on complexation and DNA collapse Langmuir 2001, 17, 1670-1673
-
(2001)
Langmuir
, vol.17
, pp. 1670-1673
-
-
Wang, Y.1
Dubin, P.L.2
Zhang, H.3
-
21
-
-
84255186262
-
Complexing a small interfering RNA with divalent cationic surfactants
-
Ristori, S.; Ciani, L.; Candiani, G.; Battistini, C.; Frati, A.; Grillo, I.; In, M. Complexing a small interfering RNA with divalent cationic surfactants Soft Matter 2012, 8, 749-756
-
(2012)
Soft Matter
, vol.8
, pp. 749-756
-
-
Ristori, S.1
Ciani, L.2
Candiani, G.3
Battistini, C.4
Frati, A.5
Grillo, I.6
In, M.7
-
23
-
-
79955005403
-
Recent development in lipid-based pharmaceutical nanocarriers
-
Musacchio, T.; Torchilin, V. P. Recent development in lipid-based pharmaceutical nanocarriers Front. Biosci. 2011, 16, 1388-1412
-
(2011)
Front. Biosci.
, vol.16
, pp. 1388-1412
-
-
Musacchio, T.1
Torchilin, V.P.2
-
24
-
-
0025341615
-
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
-
Klibanov, A. L.; Maruyama, K.; Torchilin, V. P.; Huang, L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett. 1990, 268, 235-237
-
(1990)
FEBS Lett.
, vol.268
, pp. 235-237
-
-
Klibanov, A.L.1
Maruyama, K.2
Torchilin, V.P.3
Huang, L.4
-
25
-
-
34249044829
-
Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: Relating plasma circulation lifetimes to protein binding
-
Dos Santos, N.; Allen, C.; Doppen, A. M.; Anantha, M.; Cox, K. A. K.; Gallagher, R. C.; Karlsson, G.; Edward, K.; Kenner, G.; Samuels, L.; Webb, M. S.; Bally, M. B. Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding Biochim. Biophys. Acta 2007, 1768, 1367-1377
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 1367-1377
-
-
Dos Santos, N.1
Allen, C.2
Doppen, A.M.3
Anantha, M.4
Cox, K.A.K.5
Gallagher, R.C.6
Karlsson, G.7
Edward, K.8
Kenner, G.9
Samuels, L.10
Webb, M.S.11
Bally, M.B.12
-
26
-
-
84858341506
-
Novel analytical method to evaluate the surface condition of polyethylene glycol-modified liposomes
-
Yoshino, K.; Taguchi, K.; Mochizuki, M.; Nozawa, S.; Kasukawa, H. Novel analytical method to evaluate the surface condition of polyethylene glycol-modified liposomes Colloids Surf., A 2012, 397, 73-79
-
(2012)
Colloids Surf., A
, vol.397
, pp. 73-79
-
-
Yoshino, K.1
Taguchi, K.2
Mochizuki, M.3
Nozawa, S.4
Kasukawa, H.5
-
27
-
-
84873252557
-
Liposomal drug delivery systems: From concept to clinical applications
-
Allen, T. M.; Cullis, P. R. Liposomal drug delivery systems: from concept to clinical applications Adv. Drug Delivery Rev. 2013, 65, 36-48
-
(2013)
Adv. Drug Delivery Rev.
, vol.65
, pp. 36-48
-
-
Allen, T.M.1
Cullis, P.R.2
-
28
-
-
67349215495
-
Lipid-based systemic delivery of siRNA
-
Tseng, Y. C.; Mozumda, S.; Huang, L. Lipid-based systemic delivery of siRNA Adv. Drug Delivery 2009, 61, 721-731
-
(2009)
Adv. Drug Delivery
, vol.61
, pp. 721-731
-
-
Tseng, Y.C.1
Mozumda, S.2
Huang, L.3
-
29
-
-
0035856764
-
Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA
-
Olbrich, C.; Bakowsky, U.; Lehr, C. M.; Müller, R. H.; Kneuer, C. Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA J. Controlled Release 2001, 77, 345-355
-
(2001)
J. Controlled Release
, vol.77
, pp. 345-355
-
-
Olbrich, C.1
Bakowsky, U.2
Lehr, C.M.3
Müller, R.H.4
Kneuer, C.5
-
30
-
-
84863922166
-
Lipid-based nanoparticles for siRNA delivery in cancer therapy: Paradigms and challenges
-
Gomes-da-Silva, L. C.; Fonseca, N. A.; Moura, V.; Pedroso de Lima, M. C.; Simões, S. J.; Moreira, N. Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges Acc. Chem. Res. 2012, 45, 1163-1171
-
(2012)
Acc. Chem. Res.
, vol.45
, pp. 1163-1171
-
-
Gomes-Da-Silva, L.C.1
Fonseca, N.A.2
Moura, V.3
Pedroso De Lima, M.C.4
Simões, S.J.5
Moreira, N.6
-
31
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey, D. V.; Lockridge, J. A.; Shaw, L.; Blanchard, K.; Jensen, K.; Breen, W.; Hartsough, K.; Machemer, L.; Radka, S.; Jadhav, V.; Vaish, N.; Zinner, S.; Vargeese, C.; Browman, K.; Shaffer, C. S.; Jeffs, L. B.; Judge, A.; MacLachlan, I.; Polisky, B. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Nat. Biotechnol. 2005, 23, 1002-1007
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinner, S.12
Vargeese, C.13
Browman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
-
32
-
-
84865714123
-
Lipid nanoparticles containing siRNA synthesized by microfluidic mixing exhibit an electron-dense nanostructured core
-
Leung, A. K. K.; Hafez, I. M.; Baoukina, S.; Belliveau, N. M.; Zhigaltsev, I. V.; Afshinmanesh, E.; Tieleman, D. P.; Hansen, C. L.; Hope, M. J.; Cullis, P. R. Lipid nanoparticles containing siRNA synthesized by microfluidic mixing exhibit an electron-dense nanostructured core J. Phys. Chem. C 2012, 116, 18440-18450
-
(2012)
J. Phys. Chem. C
, vol.116
, pp. 18440-18450
-
-
Leung, A.K.K.1
Hafez, I.M.2
Baoukina, S.3
Belliveau, N.M.4
Zhigaltsev, I.V.5
Afshinmanesh, E.6
Tieleman, D.P.7
Hansen, C.L.8
Hope, M.J.9
Cullis, P.R.10
-
33
-
-
79954580272
-
Current prospects for RNA interference-based therapies
-
Davidson, B. L.; McCray, P. B., Jr. Current prospects for RNA interference-based therapies Nat. Genet. 2011, 12, 329-340
-
(2011)
Nat. Genet.
, vol.12
, pp. 329-340
-
-
Davidson, B.L.1
McCray Jr., P.B.2
-
34
-
-
84896896173
-
-
www.clinicaltials.gov.
-
-
-
-
35
-
-
84866564894
-
RNA interference: A futuristic tool and its therapeutic applications
-
references therein
-
Amghesom, A.; Kaushik, A.; Kaushik, J. J.; Petros, S. T. RNA interference: a futuristic tool and its therapeutic applications Saudi J. Biol. Sci. 2012, 19, 395-403 and references therein
-
(2012)
Saudi J. Biol. Sci.
, vol.19
, pp. 395-403
-
-
Amghesom, A.1
Kaushik, A.2
Kaushik, J.J.3
Petros, S.T.4
-
36
-
-
80054741160
-
RNAi: A potential new class of therapeutic for human genetic disease
-
references therein
-
Seyhan, A. A. RNAi: a potential new class of therapeutic for human genetic disease Hum. Genet. 2011, 130, 583-605 and references therein
-
(2011)
Hum. Genet.
, vol.130
, pp. 583-605
-
-
Seyhan, A.A.1
-
37
-
-
80052612021
-
TransDerm's RNAi-based skin dosorder drug moves into one-patient clinical trial
-
Macron, D. TransDerm's RNAi-based skin dosorder drug moves into one-patient clinical trial Gene Silencing News 2008, 6, 10
-
(2008)
Gene Silencing News
, vol.6
, pp. 10
-
-
Macron, D.1
-
38
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann, T. S.; Lee, A. C. H.; Akinc, A.; Bramlage, B.; Bumcrot, D.; Fedoruk, M. N.; Harborth, J.; Heyes, J. A.; Jeffs, L. B.; John, M.; Judge, A. D.; Lam, K.; McClintock, K.; Nechev, L. V.; Palmer, L. R.; Racie, T.; Röhl, I.; Seiffert, S.; Shanmugam, S.; Sood, V.; Soutschek, J.; Toudjarska, I.; Wheat, A. J.; Yaworski, E.; Zedalis, W.; Koteliansky, V.; Manoharan, M.; Vornlocher, H. P.; MacLachlan, I. RNAi-mediated gene silencing in non-human primates Nature 2006, 44, 111-114
-
(2006)
Nature
, vol.44
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.H.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Röhl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.P.28
MacLachlan, I.29
more..
-
39
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc, A.; Zumbuehl, A.; Goldberg, M.; Leshchiner, E. S.; Busini, V.; Hossain, N.; Bacallado, S. A.; Nguyen, D. N.; Fuller, J.; Alvarez, R.; Borodovsky, A.; Borland, T.; Constien, R.; de Fougerolles, A.; Dorkin, J. R.; Jayaprakash, K. N.; Jayaraman, M.; John, M.; Koteliansky, V.; Manoharan, M.; Nechev, L.; Qin, J.; Racie, T.; Raitcheva, D.; Rajeev, K. J.; Sah, D. W. Y.; Soutschek, J.; Toudjarska, I.; Vornlocher, H. P.; Zimmermann, T. S.; Langer, R.; Anderson, D. G. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Nat. Biotechnol. 2008, 26, 261-269
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 261-269
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
Leshchiner, E.S.4
Busini, V.5
Hossain, N.6
Bacallado, S.A.7
Nguyen, D.N.8
Fuller, J.9
Alvarez, R.10
Borodovsky, A.11
Borland, T.12
Constien, R.13
De Fougerolles, A.14
Dorkin, J.R.15
Jayaprakash, K.N.16
Jayaraman, M.17
John, M.18
Koteliansky, V.19
Manoharan, M.20
Nechev, L.21
Qin, J.22
Racie, T.23
Raitcheva, D.24
Rajeev, K.J.25
Sah, D.W.Y.26
Soutschek, J.27
Toudjarska, I.28
Vornlocher, H.P.29
Zimmermann, T.S.30
Langer, R.31
Anderson, D.G.32
more..
-
40
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky, M.; Grefhorst, A.; Anderson, N. N.; Racie, T. S.; Bramlage, B.; Akinc, A.; Butler, D.; Charisse, K.; Dorkin, R.; Fan, Y.; Gamba-Vitalo, C.; Hadwiger, P.; Jayaraman, M.; John, M.; Jayaprakash, K. N.; Maier, M.; Nechev, L.; Rajeev, K. G.; Read, T.; Röhl, I.; Soutschek, J.; Tan, P.; Wong, J.; Wang, G.; Zimmermann, T.; de Fougerolles, A.; Vornlocher, H. P.; Langer, R.; Anderson, D. G.; Manoharan, M.; Koteliansky, V.; Horton, J. D.; Fitzgerald, K. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 11915-11920
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
Racie, T.S.4
Bramlage, B.5
Akinc, A.6
Butler, D.7
Charisse, K.8
Dorkin, R.9
Fan, Y.10
Gamba-Vitalo, C.11
Hadwiger, P.12
Jayaraman, M.13
John, M.14
Jayaprakash, K.N.15
Maier, M.16
Nechev, L.17
Rajeev, K.G.18
Read, T.19
Röhl, I.20
Soutschek, J.21
Tan, P.22
Wong, J.23
Wang, G.24
Zimmermann, T.25
De Fougerolles, A.26
Vornlocher, H.P.27
Langer, R.28
Anderson, D.G.29
Manoharan, M.30
Koteliansky, V.31
Horton, J.D.32
Fitzgerald, K.33
more..
-
42
-
-
84864976211
-
Attacking the genome: Emerging siRNA nanocarriers from concenpt to clinic
-
Alabi, C.; Vegas, A.; Anderson, D. Attacking the genome: emerging siRNA nanocarriers from concenpt to clinic Curr. Opin. Pharmacol. 2012, 12, 427-433
-
(2012)
Curr. Opin. Pharmacol.
, vol.12
, pp. 427-433
-
-
Alabi, C.1
Vegas, A.2
Anderson, D.3
-
43
-
-
84865079107
-
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
-
Jayaraman, M.; Ansell, S. T.; Mui, B. L.; Tam, Y. K.; Chem, J.; Du, X.; Butler, D.; Eltepu, L.; Matsuda, S.; Narayanannair, J. K.; Rajeev, K. G.; Hafez, I. M.; Akinc, A.; Maier, M. A.; Tracy, M. A.; Cullis, P. R.; Madden, T. D.; Manoharan, M.; Hope, M. J. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Angew. Chem., Int. Ed. 2012, 51, 8529-8533
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 8529-8533
-
-
Jayaraman, M.1
Ansell, S.T.2
Mui, B.L.3
Tam, Y.K.4
Chem, J.5
Du, X.6
Butler, D.7
Eltepu, L.8
Matsuda, S.9
Narayanannair, J.K.10
Rajeev, K.G.11
Hafez, I.M.12
Akinc, A.13
Maier, M.A.14
Tracy, M.A.15
Cullis, P.R.16
Madden, T.D.17
Manoharan, M.18
Hope, M.J.19
-
47
-
-
84881292568
-
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics
-
Maier, M. A.; Jayaraman, M.; Matsuda, S.; Liu, J.; Barros, S.; Querbes, W.; Tam, Y. K.; Ansell, S. K.; Kumar, V.; Qin, J.; Zhang, X.; Wang, Q.; Panesar, S.; Hutabarat, R.; Carioto, M.; Hettinger, J.; Kandasamy, P.; Butler, D.; Rajeev, K. G.; Pang, B.; Charisse, K.; Fitzgerald, K.; Mui, B. L.; Du, X.; Cullis, P.; Madden, T. D.; Hope, M. J.; Manoharan, M.; Akinc, A. Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics Mol. Ther. 2013, 21, 1570-1578
-
(2013)
Mol. Ther.
, vol.21
, pp. 1570-1578
-
-
Maier, M.A.1
Jayaraman, M.2
Matsuda, S.3
Liu, J.4
Barros, S.5
Querbes, W.6
Tam, Y.K.7
Ansell, S.K.8
Kumar, V.9
Qin, J.10
Zhang, X.11
Wang, Q.12
Panesar, S.13
Hutabarat, R.14
Carioto, M.15
Hettinger, J.16
Kandasamy, P.17
Butler, D.18
Rajeev, K.G.19
Pang, B.20
Charisse, K.21
Fitzgerald, K.22
Mui, B.L.23
Du, X.24
Cullis, P.25
Madden, T.D.26
Hope, M.J.27
Manoharan, M.28
Akinc, A.29
more..
-
48
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight, K. J.; Kolykhalov, A. A.; Rice, C. M. Efficient initiation of HCV RNA replication in cell culture Science 2000, 290, 1972-1974
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
49
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song, E.; Lee, S. K.; Wang, J.; Ince, N.; Ouyang, N.; Min, J.; Chen, J.; Shankar, P.; Lieberman, J. RNA interference targeting Fas protects mice from fulminant hepatitis Nat. Med. 2003, 9, 347-351
-
(2003)
Nat. Med.
, vol.9
, pp. 347-351
-
-
Song, E.1
Lee, S.K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
50
-
-
79955603402
-
Hydrodynamic gene delivery and its applications in pharmaceutical research
-
Bonamassa, B.; Hai, L.; Liu, D. Hydrodynamic gene delivery and its applications in pharmaceutical research Pharm. Res. 2011, 28, 694-701
-
(2011)
Pharm. Res.
, vol.28
, pp. 694-701
-
-
Bonamassa, B.1
Hai, L.2
Liu, D.3
-
51
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
Palliser, D.; Chowdhury, D.; Wang, Q. Y.; Lee, S. J.; Bronson, R. T.; Knipe, D. M.; Lieberman, J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection Nature 2006, 439, 89-94
-
(2006)
Nature
, vol.439
, pp. 89-94
-
-
Palliser, D.1
Chowdhury, D.2
Wang, Q.Y.3
Lee, S.J.4
Bronson, R.T.5
Knipe, D.M.6
Lieberman, J.7
-
52
-
-
58249094519
-
Durable protection from herpes simplex virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene
-
Wu, Y.; Navarro, F.; Lal, A.; Basar, E.; Pandey, R. K.; Manoharan, M.; Feng, Y.; Lee, S. J.; Lieberman, J.; Palliser, D. Durable protection from herpes simplex virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene Cell Host Microbe 2009, 5, 84-94
-
(2009)
Cell Host Microbe
, vol.5
, pp. 84-94
-
-
Wu, Y.1
Navarro, F.2
Lal, A.3
Basar, E.4
Pandey, R.K.5
Manoharan, M.6
Feng, Y.7
Lee, S.J.8
Lieberman, J.9
Palliser, D.10
-
53
-
-
77952680862
-
Postexposure protection of non-human primates against a lethal ebola virus challenge with RNA interference: A proof-of-concept study
-
Geisbert, T. W.; Lee, A. C. H.; Robbins, M.; Geisbert, J. B.; Honko, A. N.; Sood, V.; Johnson, J. C.; de Jong, S.; Tavakoli, I.; Judge, A.; Hensley, L. E.; MacLachlan, I. Postexposure protection of non-human primates against a lethal ebola virus challenge with RNA interference: a proof-of-concept study Lancet 2010, 375, 1896-1905
-
(2010)
Lancet
, vol.375
, pp. 1896-1905
-
-
Geisbert, T.W.1
Lee, A.C.H.2
Robbins, M.3
Geisbert, J.B.4
Honko, A.N.5
Sood, V.6
Johnson, J.C.7
De Jong, S.8
Tavakoli, I.9
Judge, A.10
Hensley, L.E.11
MacLachlan, I.12
-
54
-
-
84893307640
-
-
Tekmira Pharmaceuticals Corporation. Products. http://www.tekmirapharm. com/Programs/Products.asp#ebola.
-
Products
-
-
-
55
-
-
84875422081
-
Potassium channels: Novel emerging biomarkers and targets for therapy in cancer
-
D'Amico, M.; Gasparoli, L.; Arcangeli, A. Potassium channels: novel emerging biomarkers and targets for therapy in cancer Recent Pat. Anti-Cancer Drug Discovery 2013, 8, 53-65
-
(2013)
Recent Pat. Anti-Cancer Drug Discovery
, vol.8
, pp. 53-65
-
-
D'Amico, M.1
Gasparoli, L.2
Arcangeli, A.3
-
56
-
-
84555202691
-
P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breat cancer cells
-
Navarro, G.; Sawant, R. R.; Biswas, S.; Essex, S.; Tros de Ilarduya, C.; Torchilin, V. P. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breat cancer cells Nanomedicine 2012, 7, 65-78
-
(2012)
Nanomedicine
, vol.7
, pp. 65-78
-
-
Navarro, G.1
Sawant, R.R.2
Biswas, S.3
Essex, S.4
Tros De Ilarduya, C.5
Torchilin, V.P.6
-
57
-
-
79953054576
-
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and argumentation of the effect
-
Fang, J.; Nakamura, H.; Maeda, H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and argumentation of the effect Adv. Drug Delivery Rev. 2011, 63, 136-151
-
(2011)
Adv. Drug Delivery Rev.
, vol.63
, pp. 136-151
-
-
Fang, J.1
Nakamura, H.2
Maeda, H.3
-
58
-
-
23044506285
-
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
-
Lander, C. N.; Chavez-Reyes, A.; Bucana, C.; Schmendt, R.; Deavers, M. T.; Lopez-Berestein, G.; Sood, A. K. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery Cancer Res. 2005, 65, 6910-6918
-
(2005)
Cancer Res.
, vol.65
, pp. 6910-6918
-
-
Lander, C.N.1
Chavez-Reyes, A.2
Bucana, C.3
Schmendt, R.4
Deavers, M.T.5
Lopez-Berestein, G.6
Sood, A.K.7
-
59
-
-
33746883220
-
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
-
Santel, A.; Aleku, M.; Keil, O.; Endruschat, J.; Esche, V.; Fisch, G.; Dames, S.; Löffler, K.; Fechtner, M.; Arnold, W.; Giese, K.; Klippel, A.; Kaufmann, J. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium Gene Ther. 2006, 13, 1222-1234
-
(2006)
Gene Ther.
, vol.13
, pp. 1222-1234
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
Endruschat, J.4
Esche, V.5
Fisch, G.6
Dames, S.7
Löffler, K.8
Fechtner, M.9
Arnold, W.10
Giese, K.11
Klippel, A.12
Kaufmann, J.13
-
60
-
-
33748331337
-
RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
-
Santel, A.; Aleku, M.; Keil, O.; Endruschat, J.; Esche, V.; Durieux, B.; Löffler, K.; Fechtner, M.; Röhl, T.; Fisch, G.; Dames, S.; Arnold, W.; Giese, K.; Klippel, A.; Kaufmann, J. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy Gene Ther. 2006, 13, 1360-1370
-
(2006)
Gene Ther.
, vol.13
, pp. 1360-1370
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
Endruschat, J.4
Esche, V.5
Durieux, B.6
Löffler, K.7
Fechtner, M.8
Röhl, T.9
Fisch, G.10
Dames, S.11
Arnold, W.12
Giese, K.13
Klippel, A.14
Kaufmann, J.15
-
61
-
-
65649085603
-
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
-
Judge, A. D.; Robbins, M.; Tavakoli, I.; Levi, J.; Hu, L.; Fronda, A.; Ambegia, E.; McClintock, K.; MacLachlan, I. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice J. Clin. Invest. 2009, 119, 661-673
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 661-673
-
-
Judge, A.D.1
Robbins, M.2
Tavakoli, I.3
Levi, J.4
Hu, L.5
Fronda, A.6
Ambegia, E.7
McClintock, K.8
MacLachlan, I.9
-
62
-
-
84877120847
-
First-in-man trial of a RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
-
Tabernero, J.; Shapiro, G. I.; Lorusso, P. M.; Cervantes, A.; Schwartz, G. K.; Weiss, G. J.; Paz-Ares, L.; Cho, D. C.; Infante, J. R.; Alsina, M.; Mrinal, M.; Gounder, M. M.; Falzone, R.; Harrop, J.; White, A. C. S.; Toudjarska, I.; Bumcrot, D.; Meyers, R. E.; Hinkle, G.; Svrzikapa, N.; Renta, M.; Hutabarat, R. M.; Clausen, V. A.; Cehelsky, J.; Nochur, S. V.; Gamba-Vitalo, C.; Vaishnaw, A. K.; Sah, D. W. Y.; Gollob, J. A.; Burris, H. A., III. First-in-man trial of a RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement Cancer Discovery 2013, 3, 406-417
-
(2013)
Cancer Discovery
, vol.3
, pp. 406-417
-
-
Tabernero, J.1
Shapiro, G.I.2
Lorusso, P.M.3
Cervantes, A.4
Schwartz, G.K.5
Weiss, G.J.6
Paz-Ares, L.7
Cho, D.C.8
Infante, J.R.9
Alsina, M.10
Mrinal, M.11
Gounder, M.M.12
Falzone, R.13
Harrop, J.14
White, A.C.S.15
Toudjarska, I.16
Bumcrot, D.17
Meyers, R.E.18
Hinkle, G.19
Svrzikapa, N.20
Renta, M.21
Hutabarat, R.M.22
Clausen, V.A.23
Cehelsky, J.24
Nochur, S.V.25
Gamba-Vitalo, C.26
Vaishnaw, A.K.27
Sah, D.W.Y.28
Gollob, J.A.29
Burris III, H.A.30
more..
-
63
-
-
34447122735
-
Therapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia
-
Koldehoff, M.; Steckel, N. K.; Beelen, D. W.; Elmaagacli, A. H. Therapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia Clin. Exp. Med. 2007, 7, 47-55
-
(2007)
Clin. Exp. Med.
, vol.7
, pp. 47-55
-
-
Koldehoff, M.1
Steckel, N.K.2
Beelen, D.W.3
Elmaagacli, A.H.4
-
64
-
-
55249107615
-
Stathmin 1: A novel therapeutic target for anticancer activity
-
Rana, S.; Maples, P. B.; Senzer, N.; Nemunaitis, J. Stathmin 1: a novel therapeutic target for anticancer activity Expert Rev. Anticancer Ther. 2008, 8, 1461-1470
-
(2008)
Expert Rev. Anticancer Ther.
, vol.8
, pp. 1461-1470
-
-
Rana, S.1
Maples, P.B.2
Senzer, N.3
Nemunaitis, J.4
-
65
-
-
84896888287
-
Optimization of non-viral gene therapeutics using bilamellar invaginated vesicles
-
DOI: 10.4172/2157-7412.S5-002.
-
Templeton, N. S.; Senzer, N. Optimization of non-viral gene therapeutics using bilamellar invaginated vesicles. J. Genet. Syndr. Gene Ther. 2011, December 17) 002, DOI: 10.4172/2157-7412.S5-002.
-
(2011)
J. Genet. Syndr. Gene Ther.
, Issue.DECEMBER 17
, pp. 002
-
-
Templeton, N.S.1
Senzer, N.2
|