메뉴 건너뛰기




Volumn 213, Issue 6, 2016, Pages 904-914

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

Author keywords

apoptosis; caspase; marmosets; MERS CoV; spleen; T lymphocytes; tonsil

Indexed keywords

VIRUS NUCLEOPROTEIN; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; VIRUS ANTIBODY;

EID: 84964848410     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv380     Document Type: Article
Times cited : (376)

References (50)
  • 2
    • 84867733836 scopus 로고    scopus 로고
    • Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the middle East, September 2012
    • Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill 2012; 17:20290.
    • (2012) Euro Surveill , vol.17 , pp. 20290
    • Bermingham, A.1    Chand, M.A.2    Brown, C.S.3
  • 3
    • 84959851955 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease
    • Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev 2015; 28:465-522.
    • (2015) Clin Microbiol Rev , vol.28 , pp. 465-522
    • Chan, J.F.1    Lau, S.K.2    To, K.K.3    Cheng, V.C.4    Woo, P.C.5    Yuen, K.Y.6
  • 4
    • 35448985443 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
    • Cheng VC, Lau SK, Woo PC, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev 2007; 20:660-94.
    • (2007) Clin Microbiol Rev , vol.20 , pp. 660-694
    • Cheng, V.C.1    Lau, S.K.2    Woo, P.C.3    Yuen, K.Y.4
  • 5
    • 0242717589 scopus 로고    scopus 로고
    • Coronavirus as a possible cause of severe acute respiratory syndrome
    • Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361:1319-25.
    • (2003) Lancet , vol.361 , pp. 1319-1325
    • Peiris, J.S.1    Lai, S.T.2    Poon, L.L.3
  • 6
    • 84869081784 scopus 로고    scopus 로고
    • Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?
    • Chan JF, Li KS, To KK, Cheng VC, Chen H, Yuen KY. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? J Infect 2012; 65:477-89.
    • (2012) J Infect , vol.65 , pp. 477-489
    • Chan, J.F.1    Li, K.S.2    To, K.K.3    Cheng, V.C.4    Chen, H.5    Yuen, K.Y.6
  • 7
    • 84882598788 scopus 로고    scopus 로고
    • Epidemiological, demographic, and clinical characteristics of 47 cases of middle east respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study
    • Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013; 13:752-61.
    • (2013) Lancet Infect Dis , vol.13 , pp. 752-761
    • Assiri, A.1    Al-Tawfiq, J.A.2    Al-Rabeeah, A.A.3
  • 8
    • 84906939065 scopus 로고    scopus 로고
    • Hospital-associated outbreak of middle east respiratory syndrome coronavirus: A serologic, epidemiologic, and clinical description
    • Al-Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis 2014; 59:1225-33.
    • (2014) Clin Infect Dis , vol.59 , pp. 1225-1233
    • Al-Abdallat, M.M.1    Payne, D.C.2    Alqasrawi, S.3
  • 9
    • 84874996988 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
    • Raj VS, Mou H, Smits SL, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013; 495:251-4.
    • (2013) Nature , vol.495 , pp. 251-254
    • Raj, V.S.1    Mou, H.2    Smits, S.L.3
  • 10
    • 84884978170 scopus 로고    scopus 로고
    • Interspecies transmission and emergence of novel viruses: Lessons from bats and birds
    • Chan JF, To KK, Tse H, Jin DY, Yeun KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol 2013; 21:544-55.
    • (2013) Trends Microbiol , vol.21 , pp. 544-555
    • Chan, J.F.1    To, K.K.2    Tse, H.3    Jin, D.Y.4    Yeun, K.Y.5
  • 11
    • 84877262971 scopus 로고    scopus 로고
    • Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: Implications for disease pathogenesis and clinical manifestation
    • Chan JF, Chan KH, Choi GK, et al. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis 2013; 207:1743-52.
    • (2013) J Infect Dis , vol.207 , pp. 1743-1752
    • Chan, J.F.1    Chan, K.H.2    Choi, G.K.3
  • 12
    • 84872146295 scopus 로고    scopus 로고
    • Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines
    • Muller MA, Raj VS, Muth D, et al. Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines. MBio 2012; 3:e00515-12.
    • (2012) MBio , vol.3 , pp. e00512-e00515
    • Muller, M.A.1    Raj, V.S.2    Muth, D.3
  • 13
    • 84890649426 scopus 로고    scopus 로고
    • In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during middle east respiratory syndrome (MERS) coronavirus infection
    • Eckerle I, Muller MA, Kallies S, Gotthardt DN, Drosten C. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013; 10:359.
    • (2013) Virol J , vol.10 , pp. 359
    • Eckerle, I.1    Muller, M.A.2    Kallies, S.3    Gotthardt, D.N.4    Drosten, C.5
  • 14
    • 84898850857 scopus 로고    scopus 로고
    • Active replication of middle east respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: Implications for pathogenesis
    • Zhou J, Chu H, Li C, et al. Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis. J Infect Dis 2014; 209: 1331-42.
    • (2014) J Infect Dis , vol.209 , pp. 1331-1342
    • Zhou, J.1    Chu, H.2    Li, C.3
  • 15
    • 84879571351 scopus 로고    scopus 로고
    • Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
    • Josset L, Menachery VD, Gralinski LE, et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio 2013; 4:e00165-13.
    • (2013) MBio , vol.4 , pp. e00113-e00165
    • Josset, L.1    Menachery, V.D.2    Gralinski, L.E.3
  • 16
    • 84890049888 scopus 로고    scopus 로고
    • The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of middle east respiratory syndrome coronavirus (MERSCoV) are potent interferon antagonists
    • Yang Y, Zhang L, Geng H, et al. The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERSCoV) are potent interferon antagonists. Protein Cell 2013; 4:951-61.
    • (2013) Protein Cell , vol.4 , pp. 951-961
    • Yang, Y.1    Zhang, L.2    Geng, H.3
  • 17
    • 84895534920 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response
    • Siu KL, Yeung ML, Kok KH, et al. Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response. J Virol 2014; 88:4866-76.
    • (2014) J Virol , vol.88 , pp. 4866-4876
    • Siu, K.L.1    Yeung, M.L.2    Kok, K.H.3
  • 18
    • 84886298565 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist
    • Niemeyer D, Zillinger T, Muth D, et al. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J Virol 2013; 87:12489-95.
    • (2013) J Virol , vol.87 , pp. 12489-12495
    • Niemeyer, D.1    Zillinger, T.2    Muth, D.3
  • 19
    • 84887016694 scopus 로고    scopus 로고
    • Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel middle east respiratory syndrome coronavirus: Implications for pathogenesis and treatment
    • Lau SK, Lau CC, Chan KH, et al. Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment. J Gen Virol 2013; 94:2679-90.
    • (2013) J Gen Virol , vol.94 , pp. 2679-2690
    • Lau, S.K.1    Lau, C.C.2    Chan, K.H.3
  • 20
    • 84894076838 scopus 로고    scopus 로고
    • Proteolytic processing, deubiquitinase and interferon antagonist activities of middle east respiratory syndrome coronavirus papainlike protease
    • Yang X, Chen X, Bian G, et al. Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papainlike protease. J Gen Virol 2014; 95:614-26.
    • (2014) J Gen Virol , vol.95 , pp. 614-626
    • Yang, X.1    Chen, X.2    Bian, G.3
  • 21
    • 84904015653 scopus 로고    scopus 로고
    • Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses
    • Menachery VD, Eisfeld AJ, Schafer A, et al. Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses. MBio 2014; 5:e01174-14.
    • (2014) MBio , vol.5 , pp. e01114-e01174
    • Menachery, V.D.1    Eisfeld, A.J.2    Schafer, A.3
  • 22
    • 84895742275 scopus 로고    scopus 로고
    • Productive replication of middle east respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response
    • Chu H, Zhou J, Wong BH, et al. Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. Virology 2014; 454-455:197-205.
    • (2014) Virology , vol.454-455 , pp. 197-205
    • Chu, H.1    Zhou, J.2    Wong, B.H.3
  • 23
    • 84895823870 scopus 로고    scopus 로고
    • Distinct immune response in two MERS-CoV infected patients: Can we go from bench to bedside?
    • Faure E, Poissy J, Goffard A, et al. Distinct immune response in two MERS-CoV infected patients: can we go from bench to bedside? PLoS One 2014; 9:e88716.
    • (2014) PLoS One , vol.9 , pp. e88716
    • Faure, E.1    Poissy, J.2    Goffard, A.3
  • 24
    • 0025992545 scopus 로고
    • Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes
    • Torimoto Y, Dang NH, Vivier E, Tanaka T, Schlossman SF, Morimoto C. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 1991; 147:2514-7.
    • (1991) J Immunol , vol.147 , pp. 2514-2517
    • Torimoto, Y.1    Dang, N.H.2    Vivier, E.3    Tanaka, T.4    Schlossman, S.F.5    Morimoto, C.6
  • 25
    • 0035834010 scopus 로고    scopus 로고
    • CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO
    • Ishii T, Ohnuma K, Murakami A, et al. CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO. Proc Natl Acad Sci U S A 2001; 98:12138-43.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12138-12143
    • Ishii, T.1    Ohnuma, K.2    Murakami, A.3
  • 26
    • 0027270023 scopus 로고
    • The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity
    • Tanaka T, Kameoka J, Yaron A, Schlossman SF, Morimoto C. The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc Natl Acad Sci U S A 1993; 90:4586-90.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4586-4590
    • Tanaka, T.1    Kameoka, J.2    Yaron, A.3    Schlossman, S.F.4    Morimoto, C.5
  • 27
    • 84897480727 scopus 로고    scopus 로고
    • Rapid generation of a mouse model for middle east respiratory syndrome
    • Zhao J, Li K, Wohlford-Lenane C, et al. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A 2014; 111:4970-5.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 4970-4975
    • Zhao, J.1    Li, K.2    Wohlford-Lenane, C.3
  • 28
    • 84866372498 scopus 로고    scopus 로고
    • Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages
    • Chu H, Wang JJ, Qi M, et al. Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages. Cell Host Microbe 2012; 12:360-72.
    • (2012) Cell Host Microbe , vol.12 , pp. 360-372
    • Chu, H.1    Wang, J.J.2    Qi, M.3
  • 29
    • 84891522722 scopus 로고    scopus 로고
    • An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus
    • Yao Y, Bao L, Deng W, et al. An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus. J Infect Dis 2014; 209:236-42.
    • (2014) J Infect Dis , vol.209 , pp. 236-242
    • Yao, Y.1    Bao, L.2    Deng, W.3
  • 30
    • 84907574038 scopus 로고    scopus 로고
    • Infection with MERS-CoV causes lethal pneumonia in the common marmoset
    • Falzarano D, de Wit E, Feldmann F, et al. Infection with MERS-CoV causes lethal pneumonia in the common marmoset. PLoS Pathog 2014; 10:e1004250.
    • (2014) PLoS Pathog , vol.10 , pp. e1004250
    • Falzarano, D.1    De Wit, E.2    Feldmann, F.3
  • 31
    • 84955391557 scopus 로고    scopus 로고
    • Treatment with lopinavir/ritonavir or interferon- β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset
    • Chan JF, Yao Y, Yeung ML, et al. Treatment with lopinavir/ritonavir or interferon- β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset. J Infect Dis 2015; 212:1904-13.
    • (2015) J Infect Dis , vol.212 , pp. 1904-1913
    • Chan, J.F.1    Yao, Y.2    Yeung, M.L.3
  • 32
    • 2942568032 scopus 로고    scopus 로고
    • Sensitive and specific monoclonal antibody-based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome
    • Che XY, Qiu LW, Pan YX, et al. Sensitive and specific monoclonal antibody-based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome. J Clin Microbiol 2004; 42:2629-35.
    • (2004) J Clin Microbiol , vol.42 , pp. 2629-2635
    • Che, X.Y.1    Qiu, L.W.2    Pan, Y.X.3
  • 33
    • 84938100010 scopus 로고    scopus 로고
    • Development and evaluation of novel realtime reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses
    • Chan JF, Choi GK, Tsang AK, et al. Development and evaluation of novel realtime reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses. J Clin Microbiol 2015; 53:2722-6.
    • (2015) J Clin Microbiol , vol.53 , pp. 2722-2726
    • Chan, J.F.1    Choi, G.K.2    Tsang, A.K.3
  • 34
    • 84887019388 scopus 로고    scopus 로고
    • Broad-spectrum antivirals for the emerging middle east respiratory syndrome coronavirus
    • Chan JF, Chan KH, Kao RY, et al. Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. J Infect 2013; 67:606-16.
    • (2013) J Infect , vol.67 , pp. 606-616
    • Chan, J.F.1    Chan, K.H.2    Kao, R.Y.3
  • 35
    • 84883262923 scopus 로고    scopus 로고
    • Bilateral entry and release of middle east respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells
    • Tao X, Hill TE, Morimoto C, Peters CJ, Ksiazek TG, Tseng CT. Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells. J Virol 2013; 87:9953-8.
    • (2013) J Virol , vol.87 , pp. 9953-9958
    • Tao, X.1    Hill, T.E.2    Morimoto, C.3    Peters, C.J.4    Ksiazek, T.G.5    Tseng, C.T.6
  • 36
    • 84880177352 scopus 로고    scopus 로고
    • MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment
    • de Wilde AH, Raj VS, Oudshoorn D, et al. MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment. J Gen Virol 2013; 94:1749-60.
    • (2013) J Gen Virol , vol.94 , pp. 1749-1760
    • De Wilde, A.H.1    Raj, V.S.2    Oudshoorn, D.3
  • 37
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119:493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 38
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35:495-516.
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 39
    • 0035831473 scopus 로고    scopus 로고
    • Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis
    • Slee EA, Adrain C, Martin SJ. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 2001; 276:7320-6.
    • (2001) J Biol Chem , vol.276 , pp. 7320-7326
    • Slee, E.A.1    Adrain, C.2    Martin, S.J.3
  • 40
    • 84885340898 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques
    • de Wit E, Rasmussen AL, Falzarano D, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A 2013; 110:16598-603.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 16598-16603
    • De Wit, E.1    Rasmussen, A.L.2    Falzarano, D.3
  • 41
    • 84922417105 scopus 로고    scopus 로고
    • Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels
    • Adney DR, van Doremalen N, Brown VR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 2014; 20:1999-2005.
    • (2014) Emerg Infect Dis , vol.20 , pp. 1999-2005
    • Adney, D.R.1    Van Doremalen, N.2    Brown, V.R.3
  • 42
    • 73449099678 scopus 로고    scopus 로고
    • Evasion by stealth: Inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice
    • Zhao J, Zhao J, Van Rooijen N, Perlman S. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog 2009; 5:e1000636.
    • (2009) PLoS Pathog , vol.5 , pp. e1000636
    • Zhao, J.1    Zhao, J.2    Van Rooijen, N.3    Perlman, S.4
  • 43
    • 77956038851 scopus 로고    scopus 로고
    • T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice
    • Zhao J, Zhao J, Perlman S. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol 2010; 84:9318-25.
    • (2010) J Virol , vol.84 , pp. 9318-9325
    • Zhao, J.1    Zhao, J.2    Perlman, S.3
  • 44
    • 0038523806 scopus 로고    scopus 로고
    • Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    • Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348:1967-76.
    • (2003) N Engl J Med , vol.348 , pp. 1967-1976
    • Drosten, C.1    Gunther, S.2    Preiser, W.3
  • 46
    • 84924021563 scopus 로고    scopus 로고
    • Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases
    • Poissy J, Goffard A, Parmentier-Decrucq E, et al. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases. J Clin Virol 2014; 61:275-8.
    • (2014) J Clin Virol , vol.61 , pp. 275-278
    • Poissy, J.1    Goffard, A.2    Parmentier-Decrucq, E.3
  • 47
    • 84922905284 scopus 로고    scopus 로고
    • Clinical and laboratory findings of the first imported case of middle east respiratory syndrome coronavirus to the United States
    • Kapoor M, Pringle K, Kumar A, et al. Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States. Clin Infect Dis 2014; 59:1511-8.
    • (2014) Clin Infect Dis , vol.59 , pp. 1511-1518
    • Kapoor, M.1    Pringle, K.2    Kumar, A.3
  • 48
    • 84901687660 scopus 로고    scopus 로고
    • Middle east respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands, May 2014
    • pii:20817
    • Kraaij-Dirkzwager M, Timen A, Dirksen K, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands, May 2014. Euro Surveill 2014; 19:pii:20817.
    • (2014) Euro Surveill , pp. 19
    • Kraaij-Dirkzwager, M.1    Timen, A.2    Dirksen, K.3
  • 49
    • 26944436271 scopus 로고    scopus 로고
    • Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
    • He Z, Zhao C, Dong Q, et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis 2005; 9:323-30.
    • (2005) Int J Infect Dis , vol.9 , pp. 323-330
    • He, Z.1    Zhao, C.2    Dong, Q.3
  • 50
    • 84892739389 scopus 로고    scopus 로고
    • Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
    • Doitsh G, Galloway NL, Geng X, et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 2014; 505:509-14.
    • (2014) Nature , vol.505 , pp. 509-514
    • Doitsh, G.1    Galloway, N.L.2    Geng, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.