Bilateral entry and release of middle east respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells

Journal of Virology

Volumn 87, Issue 17, 2013, Pages 9953-9958

  Tao, Xinrong ^a   Hill, Terence E ^a   Morimoto, Chikao ^b   Peters, Clarence J ^a   Ksiazek, Thomas G ^a   Tseng, Chien Te K ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT BETA INTERFERON;

APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CORONAVIRUS; CYTOPATHOGENIC EFFECT; DRUG EFFICACY; EMBRYO; EPITHELIUM CELL; HUMAN; HUMAN CELL; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; SARS CORONAVIRUS; VIRUS ENTRY; VIRUS INHIBITION; VIRUS RELEASE;

APOPTOSIS; BRONCHI; CELL LINE; CELL POLARITY; CORONAVIRUS; CYTOPATHOGENIC EFFECT, VIRAL; EPITHELIAL CELLS; HUMANS; SARS VIRUS; SPECIES SPECIFICITY; VIRUS INTERNALIZATION; VIRUS RELEASE;

EID: 84883262923     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01562-13     Document Type: Article

References (19)

1. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish Z, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the Coronavirus Study Group. J. Virol. 87:7790-7792.
2. WHO. 22 May 2013. Novel coronavirus infection-update. WHO, Geneva, Switzerland. http://www.who.int/csr/don/2013_05_22_ncov/en/index.html.
3. Peiris JS, Guan Y, Yuen KY. 2004. Severe acute respiratory syndrome. Nat. Med. 10:S88-S97.
4. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA. 2012. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio 3:e00473-12. doi:10.1128/mBio.00473-12.
5. Mossel EC, Huang C, Narayanan K, Makino S, Tesh RB, Peters CJ. 2005. Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication. J. Virol. 79: 3846-3850.
6. Tseng CTK, Huang C, Newman P, Wang N, Narayanan K, Watts DM, Makino S, Packard MM, Zaki SR, Chan TS, Peters CJ. 2007. Severe acuterespiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J. Virol. 81: 1162-1173.
7. McCray PB, Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. 2007. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J. Virol. 81:813-821.
8. Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL. 2013. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495:251-254.
9. Kindler E, Jonsdottir HR, Muth D, Hamming OJ, Hartmann R, Rodriguez R, Geffers R, Fouchier RA, Drosten C, Muller MA, Dijkman R, Thiel V. 2013. Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential. mBio 4:e00611-12. doi:10.1128/mBio.00611-12.
10. Tseng CTK, Tseng J, Perrone L, Worthy M, Popov V, Peters CJ. 2005. Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. J. Virol. 79:9470- 9479.
11. Chan PK, To KF, Lo AW, Cheung JL, Chu I, Au FW, Tong JH, Tam JS, Sung JJ, Ng HK. 2004. Persistent infection of SARS coronavirus in colonic cells in vitro. J. Med. Virol. 74:1-7.
12. Müller MA, Raj VS, Muth D, Meyer B, Kallies S, Smits SL, Wollny R, Bestebroer TM, Specht S, Suliman T, Zimmermann K, Binger T, Eckerle I, Tschapka M, Zaki AM, Osterhaus AD, Fouchier RA, Haagmans BL, Drosten C. 2012. Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines. mBio 3:e00515-12. doi:10.1128/mBio.00515-12.
13. Zielecki F, Weber M, Eickmann M, Spiegelberg L, Zaki AM, Matrosovich M, Becker S, Weber F. 2013. Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. J. Virol. 87:5300-5304.
14. de Wilde AH, Ray VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der MY, Barcena M, Haagmans BL, Snijder EJ, van den Hoogen BG. Human coronavirus-EMC replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporine or interferon-alpha treatment. J. Gen. Virol. doi:10.1099/vir.0 .052910-0, in press.
15. Morimoto C, Lord CI, Zhang C, Duke-Cohan JS, Letvin NL, Schlossman SF. 1994. Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis. Proc. Natl. Acad. Sci. U. S. A. 91:9960-9964.
16. Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Yoshikawa N, Shimizu N, Iwata S, Tanaka H, Dang NH, Morimoto C. 2004. CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1. Proc. Natl. Acad. Sci. U. S. A. 101:14186-14191.
17. Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C. 2000. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cellactivation. Proc. Natl. Acad. Sci. U. S. A. 97:8439-8444.
18. Fuk-Woo Chan J, Chan KH, Choi GKY, To KKW, Tse H, Cai JP, Yeung ML, Cheng VCC, Chen H, Che XY, Lau SKP, Woo PCY, Yuen KY. 2013. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J. Infect. Dis. 207:1743-1752.
19. Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. 2013. Cell host response to infection with novel human coronavirusEMCpredicts potential antivirals and important differences with SARS coronavirus. mBio 4:e00165-13. doi:10.1128/mBio.00165-13.