Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

mBio

Volumn 3, Issue 6, 2012, Pages

  Müller, Marcel A ^a   Raj, V Stalin ^b   Muth, Doreen ^a   Meyer, Benjamin ^a   Kallies, Stephan ^a   Smits, Saskia L ^b   Wollny, Robert ^a   Bestebroer, Theo M ^b   Specht, Sabine ^a   Suliman, Tasnim ^a   Zimmermann, Katrin ^a   Binger, Tabea ^a   Eckerle, Isabella ^a   Tschapka, Marco ^c   Zaki, Ali M ^d   Osterhaus, Albert D M E ^b   Fouchier, Ron A M ^b   Haagmans, Bart L ^b   Drosten, Christian ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ULM   (Germany)

^d DR SOLIMAN FAKEEH HOSPITAL   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; VIRUS RECEPTOR;

ANIMAL CELL; ARTICLE; BAT; CONTROLLED STUDY; CORONAVIRUS; CORONAVIRUS INFECTION; HAMSTER; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SWINE; VIRAL DISEASE IMMUNOFLUORESCENCE ASSAY; VIRAL GENE DELIVERY SYSTEM; VIRUS CELL INTERACTION; VIRUS DETECTION; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS TRANSMISSION;

CAROLLIA; CHIROPTERA; CORONAVIRUS; CRICETINAE; MAMMALIA; MYOTIS; PIPISTRELLUS; RHINOLOPHUS; ROUSETTUS; SARS CORONAVIRUS; SUIDAE;

EID: 84872146295     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00515-12     Document Type: Article

References (24)

1. Saif LJ. 2004. Animal coronaviruses: what can they teach us about the severe acute respiratory syndrome? Rev. Sci. Tech. 23:643-660.
2. Drosten C, et al. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 348:1967-1976.
3. Peiris JS, Yuen KY, Osterhaus AD, Stöhr K. 2003. The severe acute respiratory syndrome. N. Engl. J. Med. 349:2431-2441.
4. Fouchier RA, et al. 2004. A previously undescribed coronavirus associated with respiratory disease in humans. Proc. Natl. Acad. Sci. U. S. A. 101:6212-6216.
5. van der Hoek L, et al. 2004. Identification of a new human coronavirus. Nat. Med. 10:368-373.
6. Woo PC, et al. 2005. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79:884-895.
7. Woo PC, Lau SK, Huang Y, Yuen KY. 2009. Coronavirus diversity, phylogeny and interspecies jumping. Exp. Biol. Med. (Maywood) 234: 1117-1127.
8. Woo PC, et al. 2012. Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J. Virol. 86:3995-4008.
9. Biesold SE, et al. 2011. Type I interferon reaction to viral infection in interferon-competent, immortalized cell lines from the African fruit bat Eidolon helvum. PLoS One 6:e28131.
10. Corman V, et al. 2012. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 17(39):p=20285ii.
11. Graham RL, Baric RS. 2010. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J. Virol. 84: 3134-3146.
12. Huynh J, et al. 2012. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J. Virol. 86:12816-12825.
13. Lau SK, et al. 2010. Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. J. Virol. 84:11385-11394.
14. Drexler JF, et al. 2010. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J. Virol. 84:11336-11349.
15. Gloza-Rausch F, et al. 2008. Detection and prevalence patterns of group I coronaviruses in bats, northern Germany. Emerg. Infect. Dis. 14: 626-631.
16. Li W, et al. 2003. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426:450-454.
17. Bertram S, et al. 2012. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS One 7:e35876.
18. Bermingham A, et al. 2012. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East. Euro Surveill. 17(40):p=20290ii.
19. Pebody RG, et al. 2012. The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012. Euro Surveill. 17(40):p=20292ii.
20. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med. 367:1814-1820.
21. Memish Z. 2012. A new Saudi novel coronavirus case diagnosed in KSA (Kingdom of Saudi Arabia). Archive no. 20121104.1391285, Program for Monitoring Emerging Diseases (ProMedMail). International Society for Infectious Diseases, Brookline, MA.
22. Kaye M. 2006. SARS-associated coronavirus replication in cell lines. Emerg. Infect. Dis. 12:128-133.
23. Woo PC, et al. 2006. Molecular diversity of coronaviruses in bats. Virology 351:180-187.
24. Kuba K, et al. 2005. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 11:875-879.