Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

Nucleic Acids Research

Volumn 44, Issue 3, 2016, Pages

  Wang, Jianbin ^a   DeClercq, Joshua J ^a   Hayward, Samuel B ^a   Li, Patrick Wai Lun ^a   Shivak, David A ^a   Gregory, Philip D ^a   Lee, Gary ^a   Holmes, Michael C ^a  

^a SANGAMO BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHIMERIC ANTIGEN RECEPTOR; CRISPR ASSOCIATED PROTEIN; MESSENGER RNA; PARVOVIRUS VECTOR; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE; ENDONUCLEASE; ZINC FINGER PROTEIN;

ADENO ASSOCIATED VIRUS; ADOPTIVE TRANSFER; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DNA END JOINING REPAIR; DNA REPAIR; DNA SEQUENCE; DOUBLE STRANDED DNA BREAK; GENE CASSETTE; GENE DISRUPTION; GENE INSERTION; GENE LOCUS; HUMAN; IN VIVO STUDY; INVERTED TERMINAL REPEAT; POLYADENYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION SITE; RNA EDITING; SEQUENCE HOMOLOGY; T LYMPHOCYTE; VIRUS CAPSID; DEPENDOPARVOVIRUS; ENZYMOLOGY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN GENOME; METABOLISM;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DEPENDOVIRUS; ENDONUCLEASES; GENETIC VECTORS; GENOME, HUMAN; HUMANS; RNA, MESSENGER; TRANSFECTION; ZINC FINGERS;

EID: 84964788489     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv1121     Document Type: Article

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