-
2
-
-
84879813079
-
Chimeric antigen receptor-engineered t cells for cancer immunotherapy: Progress and challenges
-
Han EQ, Li X, Wang C, Li T, Han S. Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges. J Hematol Oncol. 2013; 6: 47.
-
(2013)
J Hematol Oncol
, vol.6
, pp. 47
-
-
Han, E.Q.1
Li, X.2
Wang, C.3
Li, T.4
Han, S.5
-
3
-
-
84899631361
-
Antibody-modified t cells: Cars take the front seat for hematologic malignancies
-
3. Maus MV, Grupp SA, Porter DL, June CH. Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood. 2014; 123: 2625-35.
-
(2014)
Blood
, vol.123
, pp. 2625-2635
-
-
Maus, M.V.1
Grupp, S.A.2
Porter, D.L.3
June, C.H.4
-
4
-
-
84964735057
-
Reprogramming the tumor microenvironment to enhance adoptive cellular therapy
-
Elsevier
-
4. Beavis PA, Slaney CY, Kershaw MH, Gyorki D, Neeson PJ, Darcy PK. Reprogramming the tumor microenvironment to enhance adoptive cellular therapy. Seminars in immunology: Elsevier; 2015.
-
(2015)
Seminars in Immunology
-
-
Beavis, P.A.1
Slaney, C.Y.2
Kershaw, M.H.3
Gyorki, D.4
Neeson, P.J.5
Darcy, P.K.6
-
5
-
-
10344265510
-
T cell activation by antibody-like immunoreceptors: Increase in affinity of the single-chain fragment domain above threshold does not increase t cell activation against antigen-positive target cells but decreases selectivity
-
Chmielewski M, Hombach A, Heuser C, Adams GP, Abken H. T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity. The Journal of Immunology. 2004; 173: 7647-53.
-
(2004)
The Journal of Immunology
, vol.173
, pp. 7647-7653
-
-
Chmielewski, M.1
Hombach, A.2
Heuser, C.3
Adams, G.P.4
Abken, H.5
-
6
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. cell. 2011; 144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
84951801466
-
Car t-cell immunotherapy: The path from the by-road to the freeway?
-
7. Whilding LM, Maher J. CAR T-cell immunotherapy: The path from the by-road to the freeway? Molecular oncology. 2015; 9: 1994-2018.
-
(2015)
Molecular Oncology
, vol.9
, pp. 1994-2018
-
-
Whilding, L.M.1
Maher, J.2
-
8
-
-
84908145811
-
Chimeric antigen receptor for adoptive immunotherapy of cancer: Latest research and future prospects
-
Shi H, Sun M, Liu L, Wang Z. Chimeric antigen receptor for adoptive immunotherapy of cancer: Latest research and future prospects. Molecular cancer. 2014; 13: 219.
-
(2014)
Molecular Cancer
, vol.13
, pp. 219
-
-
Shi, H.1
Sun, M.2
Liu, L.3
Wang, Z.4
-
9
-
-
84953344459
-
The non-signaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity
-
Hudecek M, Sommermeyer D, Kosasih PL, Silva-Benedict A, Liu L, Rader C, et al. The non-signaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. Cancer immunology research. 2014: canimm.0127.2014.
-
(2014)
Cancer Immunology Research. 2014: Canimm
, pp. 0127
-
-
Hudecek, M.1
Sommermeyer, D.2
Kosasih, P.L.3
Silva-Benedict, A.4
Liu, L.5
Rader, C.6
-
10
-
-
84964727934
-
Adoptive t cell therapies: A comparison of t cell receptors and chimeric antigen receptors
-
10. Harris DT, Kranz DM. Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors. Trends in Pharmacological Sciences. 2015.
-
(2015)
Trends in Pharmacological Sciences
-
-
Harris, D.T.1
Kranz, D.M.2
-
11
-
-
84890181067
-
Design and development of therapies using chimeric antigen receptor‐expressing t cells
-
Dotti G, Gottschalk S, Savoldo B, Brenner MK. Design and development of therapies using chimeric antigen receptor‐expressing T cells. Immunological reviews. 2014; 257: 107-26.
-
(2014)
Immunological Reviews
, vol.257
, pp. 107-126
-
-
Dotti, G.1
Gottschalk, S.2
Savoldo, B.3
Brenner, M.K.4
-
12
-
-
79955517235
-
Cd28 costimulation improves expansion and persistence of chimeric antigen receptor–modified t cells in lymphoma patients
-
Savoldo B, Ramos CA, Liu E, Mims MP, Keating MJ, Carrum G, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients. The Journal of clinical investigation. 2011; 121: 1822.
-
(2011)
The Journal of Clinical Investigation
, vol.121
, pp. 1822
-
-
Savoldo, B.1
Ramos, C.A.2
Liu, E.3
Mims, M.P.4
Keating, M.J.5
Carrum, G.6
-
13
-
-
77953647938
-
The optimal antigen response of chimeric antigen receptors harboring the cd3ζ transmembrane domain is dependent upon incorporation of the receptor into the endogenous tcr/cd3 complex
-
Bridgeman JS, Hawkins RE, Bagley S, Blaylock M, Holland M, Gilham DE. The optimal antigen response of chimeric antigen receptors harboring the CD3ζ transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex. The Journal of Immunology. 2010; 184: 6938-49.
-
(2010)
The Journal of Immunology
, vol.184
, pp. 6938-6949
-
-
Bridgeman, J.S.1
Hawkins, R.E.2
Bagley, S.3
Blaylock, M.4
Holland, M.5
Gilham, D.E.6
-
15
-
-
84918558415
-
Chimeric antigen receptor t-cell therapy to target hematologic malignancies
-
Kenderian SS, Ruella M, Gill S, Kalos M. Chimeric antigen receptor T-cell therapy to target hematologic malignancies. Cancer research. 2014; 74: 6383-9.
-
(2014)
Cancer Research
, vol.74
, pp. 6383-6389
-
-
Kenderian, S.S.1
Ruella, M.2
Gill, S.3
Kalos, M.4
-
16
-
-
76349087378
-
Chimeric antigen receptors combining 4-1bb and cd28 signaling domains augment pi3kinase/akt/bcl-xl activation and cd8+ t cell–mediated tumor eradication
-
Zhong X-S, Matsushita M, Plotkin J, Riviere I, Sadelain M. Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication. Molecular Therapy. 2010; 18: 413-20.
-
(2010)
Molecular Therapy
, vol.18
, pp. 413-420
-
-
Zhong, X.-S.1
Matsushita, M.2
Plotkin, J.3
Riviere, I.4
Sadelain, M.5
-
17
-
-
84930765209
-
4-1bb costimulation ameliorates t cell exhaustion induced by tonic signaling of chimeric antigen receptors
-
17. Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nature medicine. 2015.
-
(2015)
Nature Medicine
-
-
Long, A.H.1
Haso, W.M.2
Shern, J.F.3
Wanhainen, K.M.4
Murgai, M.5
Ingaramo, M.6
-
18
-
-
84938702933
-
Mhc-i modulation due to changes in tumor cell metabolism regulates tumor sensitivity to ctl and nk cells
-
Catalán E, Charni S, Jaime P, Aguiló JI, Enríquez JA, Naval J, et al. MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells. Oncoimmunology. 2015; 4: e985924.
-
(2015)
Oncoimmunology
, vol.4
-
-
Catalán, E.1
Charni, S.2
Jaime, P.3
Aguiló, J.I.4
Enríquez, J.A.5
Naval, J.6
-
19
-
-
84937760760
-
Chimeric antigen receptor-engineered t cells for the treatment of metastatic prostate cancer
-
Hillerdal V, Essand M. Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer. BioDrugs. 2015; 29: 75-89.
-
(2015)
Biodrugs
, vol.29
, pp. 75-89
-
-
Hillerdal, V.1
Essand, M.2
-
21
-
-
84908073316
-
Chimeric antigen receptor t cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. New England Journal of Medicine. 2014; 371: 1507-17.
-
(2014)
New England Journal of Medicine
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
Aplenc, R.4
Barrett, D.M.5
Bunin, N.J.6
-
22
-
-
84877835997
-
Galal a. Immunotherapy for b-cell neoplasms using t cells expressing chimeric antigen receptors: From antigen choice to clinical implementation
-
Boulassel M-R, Galal A. Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation. Sultan Qaboos University medical journal. 2012; 12: 273.
-
(2012)
Sultan Qaboos University Medical Journal
, vol.12
, pp. 273
-
-
Boulassel, M.-R.1
-
23
-
-
84931062534
-
Nature of tumor control by permanently and transiently modified gd2 chimeric antigen receptor t cells in xenograft models of neuroblastoma
-
Singh N, Liu X, Hulitt J, Jiang S, June CH, Grupp SA, et al. Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma. Cancer Immunol Res. 2014; 2: 1059-70.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 1059-1070
-
-
Singh, N.1
Liu, X.2
Hulitt, J.3
Jiang, S.4
June, C.H.5
Grupp, S.A.6
-
24
-
-
84890207337
-
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
-
Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, et al. T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer immunology research. 2013; 1: 26-31.
-
(2013)
Cancer Immunology Research
, vol.1
, pp. 26-31
-
-
Maus, M.V.1
Haas, A.R.2
Beatty, G.L.3
Albelda, S.M.4
Levine, B.L.5
Liu, X.6
-
25
-
-
33750700474
-
The use of a tropism-modified measles virus in folate receptor–targeted virotherapy of ovarian cancer
-
Hasegawa K, Nakamura T, Harvey M, Ikeda Y, Oberg A, Figini M, et al. The use of a tropism-modified measles virus in folate receptor–targeted virotherapy of ovarian cancer. Clinical Cancer Research. 2006; 12: 6170-8.
-
(2006)
Clinical Cancer Research
, vol.12
, pp. 6170-6178
-
-
Hasegawa, K.1
Nakamura, T.2
Harvey, M.3
Ikeda, Y.4
Oberg, A.5
Figini, M.6
-
26
-
-
84864518399
-
A phase i clinical trial of adoptive transfer of folate receptor-alpha redirected autologous t cells for recurrent ovarian cancer
-
Kandalaft LE, Powell Jr DJ, Coukos G. A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer. J Transl Med. 2012; 10: 157.
-
(2012)
J Transl Med
, vol.10
, pp. 157
-
-
Kandalaft, L.E.1
Powell, D.J.2
Coukos, G.3
-
27
-
-
33947265424
-
Adoptive transfer of chimeric antigen receptor re-directed cytolytic t lymphocyte clones in patients with neuroblastoma
-
Park JR, DiGiusto DL, Slovak M, Wright C, Naranjo A, Wagner J, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Molecular Therapy. 2007; 15: 825-33.
-
(2007)
Molecular Therapy
, vol.15
, pp. 825-833
-
-
Park, J.R.1
Digiusto, D.L.2
Slovak, M.3
Wright, C.4
Naranjo, A.5
Wagner, J.6
-
28
-
-
34848818523
-
Cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo. Cancer immunology
-
Lamers CH, Langeveld SC, Groot-van Ruijven CM, Debets R, Sleijfer S, Gratama JW. Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo. Cancer Immunology, Immunotherapy. 2007; 56: 1875-83.
-
(2007)
Immunotherapy
, vol.56
, pp. 1875-1883
-
-
Lamers, C.H.1
Langeveld, S.C.2
Groot-Van Ruijven, C.M.3
Debets, R.4
Sleijfer, S.5
Gratama, J.W.6
Gene-Modified, T.7
-
29
-
-
55549145071
-
Virus-specific t cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
-
Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nature medicine. 2008; 14: 1264-70.
-
(2008)
Nature Medicine
, vol.14
, pp. 1264-1270
-
-
Pule, M.A.1
Savoldo, B.2
Myers, G.D.3
Rossig, C.4
Russell, H.V.5
Dotti, G.6
-
30
-
-
82955207691
-
Antitumor activity and long-term fate of chimeric antigen receptor–positive t cells in patients with neuroblastoma
-
Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, et al. Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma. Blood. 2011; 118: 6050-6.
-
(2011)
Blood
, vol.118
, pp. 6050-6056
-
-
Louis, C.U.1
Savoldo, B.2
Dotti, G.3
Pule, M.4
Yvon, E.5
Myers, G.D.6
-
31
-
-
84871391438
-
Re-directed t cells for the treatment of fibroblast activation protein (fap)-positive malignant pleural mesothelioma (fapme-1)
-
Petrausch U, Schuberth PC, Hagedorn C, Soltermann A, Tomaszek S, Stahel R, et al. Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1). BMC cancer. 2012; 12: 615.
-
(2012)
BMC Cancer
, vol.12
, pp. 615
-
-
Petrausch, U.1
Schuberth, P.C.2
Hagedorn, C.3
Soltermann, A.4
Tomaszek, S.5
Stahel, R.6
-
32
-
-
77952420345
-
Gene-modified t cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the lewis y antigen
-
Peinert S, Prince H, Guru P, Kershaw M, Smyth M, Trapani J, et al. Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther. 2010; 17: 678-86.
-
(2010)
Gene Ther
, vol.17
, pp. 678-686
-
-
Peinert, S.1
Prince, H.2
Guru, P.3
Kershaw, M.4
Smyth, M.5
Trapani, J.6
-
33
-
-
84887419384
-
Persistence and efficacy of second generation car t cell against the ley antigen in acute myeloid leukemia
-
Ritchie DS, Neeson PJ, Khot A, Peinert S, Tai T, Tainton K, et al. Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Molecular Therapy. 2013; 21: 2122-9.
-
(2013)
Molecular Therapy
, vol.21
, pp. 2122-2129
-
-
Ritchie, D.S.1
Neeson, P.J.2
Khot, A.3
Peinert, S.4
Tai, T.5
Tainton, K.6
-
34
-
-
77950475517
-
Case report of a serious adverse event following the administration of t cells transduced with a chimeric antigen receptor recognizing erbb2
-
Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Molecular Therapy. 2010; 18: 843-51.
-
(2010)
Molecular Therapy
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
Dudley, M.E.4
Laurencot, C.M.5
Rosenberg, S.A.6
-
35
-
-
78549253550
-
Multiple injections of electroporated autologous t cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
-
Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer research. 2010; 70: 9053-61.
-
(2010)
Cancer Research
, vol.70
, pp. 9053-9061
-
-
Zhao, Y.1
Moon, E.2
Carpenito, C.3
Paulos, C.M.4
Liu, X.5
Brennan, A.L.6
-
36
-
-
84860333968
-
Cd20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both cd28 and 4-1bb domains: Pilot clinical trial results
-
Till BG, Jensen MC, Wang J, Qian X, Gopal AK, Maloney DG, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood. 2012; 119: 3940-50.
-
(2012)
Blood
, vol.119
, pp. 3940-3950
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Qian, X.4
Gopal, A.K.5
Maloney, D.G.6
-
37
-
-
84894443958
-
Definition and application of good manufacturing process-compliant production of cea-specific chimeric antigen receptor expressing t-cells for phase i/ii clinical trial
-
Guest RD, Kirillova N, Mowbray S, Gornall H, Rothwell DG, Cheadle EJ, et al. Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial. Cancer immunology, immunotherapy: CII. 2014; 63: 133-45.
-
(2014)
Cancer Immunology, Immunotherapy: CII
, vol.63
, pp. 133-145
-
-
Guest, R.D.1
Kirillova, N.2
Mowbray, S.3
Gornall, H.4
Rothwell, D.G.5
Cheadle, E.J.6
-
38
-
-
75149170229
-
T-cell engineering for cancer immunotherapy
-
Sadelain M. T-cell engineering for cancer immunotherapy. The Cancer Journal. 2009; 15: 451-5.
-
(2009)
The Cancer Journal
, vol.15
, pp. 451-455
-
-
Sadelain, M.1
-
39
-
-
84890205877
-
Car-modified anti-cd19 t cells for the treatment of b-cell malignancies: Rules of the road
-
Gill S, Porter DL. CAR-modified anti-CD19 T cells for the treatment of B-cell malignancies: Rules of the road. Expert opinion on biological therapy. 2014; 14: 37-49.
-
(2014)
Expert Opinion on Biological Therapy
, vol.14
, pp. 37-49
-
-
Gill, S.1
Porter, D.L.2
-
40
-
-
33947636183
-
Breakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapy
-
Trifilio S, Bennett C, Yarnold P, McKoy J, Parada J, Mehta J, et al. Breakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapy. Bone marrow transplantation. 2007; 39: 425-9.
-
(2007)
Bone Marrow Transplantation
, vol.39
, pp. 425-429
-
-
Trifilio, S.1
Bennett, C.2
Yarnold, P.3
Mckoy, J.4
Parada, J.5
Mehta, J.6
-
41
-
-
79953054576
-
The epr effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
-
Fang J, Nakamura H, Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Advanced drug delivery reviews. 2011; 63: 136-51.
-
(2011)
Advanced Drug Delivery Reviews
, vol.63
, pp. 136-151
-
-
Fang, J.1
Nakamura, H.2
Maeda, H.3
-
42
-
-
0034000453
-
Tumor vascular permeability and the epr effect in macromolecular therapeutics: A review
-
Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. Journal of controlled release. 2000; 65: 271-84.
-
(2000)
Journal of Controlled Release
, vol.65
, pp. 271-284
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
Matsumura, Y.4
Hori, K.5
-
43
-
-
80052236068
-
Human solid tumors contain high endothelial venules: Association with t-and b-lymphocyte infiltration and favorable prognosis in breast cancer
-
Martinet L, Garrido I, Filleron T, Le Guellec S, Bellard E, Fournie J-J, et al. Human solid tumors contain high endothelial venules: association with T-and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer research. 2011; 71: 5678-87.
-
(2011)
Cancer Research
, vol.71
, pp. 5678-5687
-
-
Martinet, L.1
Garrido, I.2
Filleron, T.3
Le Guellec, S.4
Bellard, E.5
Fournie, J.-J.6
-
44
-
-
29144514645
-
Effector memory t cells, early metastasis, and survival in colorectal cancer
-
Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. New England Journal of Medicine. 2005; 353: 2654-66.
-
(2005)
New England Journal of Medicine
, vol.353
, pp. 2654-2666
-
-
Pagès, F.1
Berger, A.2
Camus, M.3
Sanchez-Cabo, F.4
Costes, A.5
Molidor, R.6
-
45
-
-
84928759208
-
Adoptive cell transfer as personalized immunotherapy for human cancer
-
Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science. 2015; 348: 62-8.
-
(2015)
Science
, vol.348
, pp. 62-68
-
-
Rosenberg, S.A.1
Restifo, N.P.2
-
46
-
-
0037448353
-
Intratumoral t cells, recurrence, and survival in epithelial ovarian cancer
-
Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. New England Journal of Medicine. 2003; 348: 203-13.
-
(2003)
New England Journal of Medicine
, vol.348
, pp. 203-213
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Katsaros, D.3
Gimotty, P.A.4
Massobrio, M.5
Regnani, G.6
-
47
-
-
33847611968
-
Programmed cell death 1 ligand 1 and tumor-infiltrating cd8+ t lymphocytes are prognostic factors of human ovarian cancer
-
Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proceedings of the National Academy of Sciences. 2007; 104: 3360-5.
-
(2007)
Proceedings of the National Academy of Sciences
, vol.104
, pp. 3360-3365
-
-
Hamanishi, J.1
Mandai, M.2
Iwasaki, M.3
Okazaki, T.4
Tanaka, Y.5
Yamaguchi, K.6
-
48
-
-
84975596806
-
Enhanced permeability and retention (epr) effect based tumor targeting: The concept, application and prospect
-
Yin H, Liao L, Fang J. Enhanced permeability and retention (EPR) effect based tumor targeting: the concept, application and prospect. JSM Clin Oncol Res. 2014; 2: 1010-4.
-
(2014)
JSM Clin Oncol Res
, vol.2
, pp. 1010-1014
-
-
Yin, H.1
Liao, L.2
Fang, J.3
-
49
-
-
84862339754
-
Tumor microenvironment and lymphocyte infiltration. Cancer immunology
-
49. Rahir G, Moser M. Tumor microenvironment and lymphocyte infiltration. Cancer Immunology, Immunotherapy. 2012; 61: 751-9.
-
(2012)
Immunotherapy
, vol.61
, pp. 751-759
-
-
Rahir, G.1
Moser, M.2
-
51
-
-
84881397413
-
High endothelial venules (hevs) in human melanoma lesions: Major gateways for tumor-infiltrating lymphocytes
-
Martinet L, Le Guellec S, Filleron T, Lamant L, Meyer N, Rochaix P, et al. High endothelial venules (HEVs) in human melanoma lesions: major gateways for tumor-infiltrating lymphocytes. Oncoimmunology. 2012; 1: 829-39.
-
(2012)
Oncoimmunology
, vol.1
, pp. 829-839
-
-
Martinet, L.1
Le Guellec, S.2
Filleron, T.3
Lamant, L.4
Meyer, N.5
Rochaix, P.6
-
52
-
-
38049000452
-
Endothelin b receptor mediates the endothelial barrier to t cell homing to tumors and disables immune therapy
-
Buckanovich RJ, Facciabene A, Kim S, Benencia F, Sasaroli D, Balint K, et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nature medicine. 2008; 14: 28-36.
-
(2008)
Nature Medicine
, vol.14
, pp. 28-36
-
-
Buckanovich, R.J.1
Facciabene, A.2
Kim, S.3
Benencia, F.4
Sasaroli, D.5
Balint, K.6
-
53
-
-
0037699015
-
Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression
-
Dirkx AE, oude Egbrink MG, Kuijpers MJ, van der Niet ST, Heijnen VV, Bouma-ter Steege JC, et al. Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer research. 2003; 63: 2322-9.
-
(2003)
Cancer Research
, vol.63
, pp. 2322-2329
-
-
Dirkx, A.E.1
Oude Egbrink, M.G.2
Kuijpers, M.J.3
Van Der Niet, S.T.4
Heijnen, V.V.5
Bouma-Ter Steege, J.C.6
-
54
-
-
0034090097
-
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
-
Griffioen AW, Molema G. Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacological reviews. 2000; 52: 237-68.
-
(2000)
Pharmacological Reviews
, vol.52
, pp. 237-268
-
-
Griffioen, A.W.1
Molema, G.2
-
55
-
-
0030044629
-
Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: The role of angiogenic factors
-
Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G. Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: The role of angiogenic factors. Cancer research. 1996; 56: 1111-7.
-
(1996)
Cancer Research
, vol.56
, pp. 1111-1117
-
-
Griffioen, A.W.1
Damen, C.A.2
Martinotti, S.3
Blijham, G.H.4
Groenewegen, G.5
-
56
-
-
84903225774
-
-
Active immunization against tumor necrosis factor-alpha decreases proinflammatory cytokines, oxidative stress mediators and adhesion molecules risk factors in streptozotocin-induced diabetic rats. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders)
-
56. J Tuorkey M, K Abdul-Aziz K, A Zidan A-A. Active immunization against tumor necrosis factor-alpha decreases proinflammatory cytokines, oxidative stress mediators and adhesion molecules risk factors in streptozotocin-induced diabetic rats. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders). 2013; 13: 269-74.
-
(2013)
, vol.13
, pp. 269-274
-
-
J Tuorkey, M.1
K Abdul-Aziz, K.2
A Zidan, A.-A.3
-
57
-
-
84949556667
-
The role of chemokines in shaping the balance between cd4+ t cell subsets and its therapeutic implications in autoimmune and cancer diseases
-
Karin N, Wildbaum G. The Role of Chemokines in Shaping the Balance Between CD4+ T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases. Frontiers in immunology. 2015; 6.
-
(2015)
Frontiers in Immunology
, pp. 6
-
-
Karin, N.1
Wildbaum, G.2
-
58
-
-
0027982876
-
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
-
Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. cell. 1994; 76: 301-14.
-
(1994)
Cell
, vol.76
, pp. 301-314
-
-
Springer, T.A.1
-
59
-
-
0036428790
-
Redirecting migration of t cells to chemokine secreted from tumors by genetic modification with cxcr2
-
Kershaw MH, Wang G, Westwood JA, Pachynski RK, Tiffany HL, Marincola FM, et al. Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum Gene Ther. 2002; 13: 1971-80.
-
(2002)
Hum Gene Ther
, vol.13
, pp. 1971-1980
-
-
Kershaw, M.H.1
Wang, G.2
Westwood, J.A.3
Pachynski, R.K.4
Tiffany, H.L.5
Marincola, F.M.6
-
60
-
-
77958063691
-
Enhanced tumor trafficking of gd2 chimeric antigen receptor t cells by expression of the chemokine receptor ccr2b
-
(Hagerstown, Md: 1997)
-
60. Craddock JA, Lu A, Bear A, Pule M, Brenner MK, Rooney CM, et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. Journal of immunotherapy (Hagerstown, Md: 1997). 2010; 33: 780.
-
(2010)
Journal of Immunotherapy
, vol.33
, pp. 780
-
-
Craddock, J.A.1
Lu, A.2
Bear, A.3
Pule, M.4
Brenner, M.K.5
Rooney, C.M.6
-
61
-
-
67650638846
-
T lymphocytes coexpressing ccr4 and a chimeric antigen receptor targeting cd30 have improved homing and antitumor activity in a hodgkin tumor model
-
Di Stasi A, De Angelis B, Rooney CM, Zhang L, Mahendravada A, Foster AE, et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood. 2009; 113: 6392-402.
-
(2009)
Blood
, vol.113
, pp. 6392-6402
-
-
Di Stasi, A.1
De Angelis, B.2
Rooney, C.M.3
Zhang, L.4
Mahendravada, A.5
Foster, A.E.6
-
62
-
-
84862838257
-
Chimeric antigen receptors for t cell immunotherapy: Current understanding and future directions
-
Curran KJ, Pegram HJ, Brentjens RJ. Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions. The journal of gene medicine. 2012; 14: 405-15.
-
(2012)
The Journal of Gene Medicine
, vol.14
, pp. 405-415
-
-
Curran, K.J.1
Pegram, H.J.2
Brentjens, R.J.3
-
63
-
-
84907546628
-
Armed oncolytic virus enhances immune functions of chimeric antigen receptor–modified t cells in solid tumors
-
Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, et al. Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors. Cancer research. 2014; 74: 5195-205.
-
(2014)
Cancer Research
, vol.74
, pp. 5195-5205
-
-
Nishio, N.1
Diaconu, I.2
Liu, H.3
Cerullo, V.4
Caruana, I.5
Hoyos, V.6
-
64
-
-
84908891854
-
Regional delivery of mesothelin-targeted car t cell therapy generates potent and long-lasting cd4-dependent tumor immunity
-
261ra151-261ra151
-
64. Adusumilli PS, Cherkassky L, Villena-Vargas J, Colovos C, Servais E, Plotkin J, et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Science translational medicine. 2014; 6: 261ra151-261ra151.
-
(2014)
Science Translational Medicine
, vol.6
-
-
Adusumilli, P.S.1
Cherkassky, L.2
Villena-Vargas, J.3
Colovos, C.4
Servais, E.5
Plotkin, J.6
-
65
-
-
84890559796
-
Intracerebral delivery of a third generation egfrviii-specific chimeric antigen receptor is efficacious against human glioma
-
Choi BD, Suryadevara CM, Gedeon PC, Herndon II JE, Sanchez-Perez L, Bigner DD, et al. Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. Journal of Clinical Neuroscience. 2014; 21: 189-90.
-
(2014)
Journal of Clinical Neuroscience
, vol.21
, pp. 189-190
-
-
Choi, B.D.1
Suryadevara, C.M.2
Gedeon, P.C.3
Herndon, I.J.4
Sanchez-Perez, L.5
Bigner, D.D.6
-
66
-
-
84858759305
-
Tumor-targeted t cells modified to secrete il-12 eradicate systemic tumors without need for prior conditioning
-
Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, Sadelain M, et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012; 119: 4133-41.
-
(2012)
Blood
, vol.119
, pp. 4133-4141
-
-
Pegram, H.J.1
Lee, J.C.2
Hayman, E.G.3
Imperato, G.H.4
Tedder, T.F.5
Sadelain, M.6
-
67
-
-
77956280888
-
Tumor-specific cd8+ t cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts
-
Kerkar SP, Muranski P, Kaiser A, Boni A, Sanchez-Perez L, Yu Z, et al. Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Cancer research. 2010; 70: 6725-34.
-
(2010)
Cancer Research
, vol.70
, pp. 6725-6734
-
-
Kerkar, S.P.1
Muranski, P.2
Kaiser, A.3
Boni, A.4
Sanchez-Perez, L.5
Yu, Z.6
-
68
-
-
84890179288
-
Of cars and trucks: Chimeric antigen receptor (car) t cells engineered with an inducible cytokine to modulate the tumor stroma
-
Chmielewski M, Hombach AA, Abken H. Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma. Immunological reviews. 2014; 257: 83-90.
-
(2014)
Immunological Reviews
, vol.257
, pp. 83-90
-
-
Chmielewski, M.1
Hombach, A.A.2
Abken, H.3
-
69
-
-
80052257433
-
Il-12 release by engineered t cells expressing chimeric antigen receptors can effectively muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression
-
Chmielewski M, Kopecky C, Hombach AA, Abken H. IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression. Cancer research. 2011; 71: 5697-706.
-
(2011)
Cancer Research
, vol.71
, pp. 5697-5706
-
-
Chmielewski, M.1
Kopecky, C.2
Hombach, A.A.3
Abken, H.4
-
70
-
-
79953325686
-
Improving adoptive t cell therapy by targeting and controlling il-12 expression to the tumor environment
-
Zhang L, Kerkar SP, Yu Z, Zheng Z, Yang S, Restifo NP, et al. Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. Molecular Therapy. 2011; 19: 751-9.
-
(2011)
Molecular Therapy
, vol.19
, pp. 751-759
-
-
Zhang, L.1
Kerkar, S.P.2
Yu, Z.3
Zheng, Z.4
Yang, S.5
Restifo, N.P.6
-
71
-
-
84924328621
-
Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor t cells specific for tumor antigen gd2
-
Gargett T, Brown MP. Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2. Cytotherapy. 2015; 17: 487-95.
-
(2015)
Cytotherapy
, vol.17
, pp. 487-495
-
-
Gargett, T.1
Brown, M.P.2
-
72
-
-
32644448488
-
A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via cd3/cd28 costimulation
-
Porter DL, Levine BL, Bunin N, Stadtmauer EA, Luger SM, Goldstein S, et al. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood. 2006; 107: 1325-31.
-
(2006)
Blood
, vol.107
, pp. 1325-1331
-
-
Porter, D.L.1
Levine, B.L.2
Bunin, N.3
Stadtmauer, E.A.4
Luger, S.M.5
Goldstein, S.6
-
73
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti–pd-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu W-J, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti–PD-1) in melanoma. New England Journal of Medicine. 2013; 369: 134-44.
-
(2013)
New England Journal of Medicine
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.-J.5
Kefford, R.6
-
74
-
-
33646186619
-
Diverse functions of il-2, il-15, and il-7 in lymphoid homeostasis
-
Ma A, Koka R, Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol. 2006; 24: 657-79.
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 657-679
-
-
Ma, A.1
Koka, R.2
Burkett, P.3
-
75
-
-
84902590274
-
Closely related t-memory stem cells correlate with in vivo expansion of car. Cd19-t cells and are preserved by il-7 and il-15
-
Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR. CD19-T cells and are preserved by IL-7 and IL-15. Blood. 2014; 123: 3750-9.
-
(2014)
Blood
, vol.123
, pp. 3750-3759
-
-
Xu, Y.1
Zhang, M.2
Ramos, C.A.3
Durett, A.4
Liu, E.5
Dakhova, O.6
-
77
-
-
84875745673
-
Interplay between the cancer genome and epigenome
-
Shen H, Laird PW. Interplay between the cancer genome and epigenome. cell. 2013; 153: 38-55.
-
(2013)
Cell.
, vol.153
, pp. 38-55
-
-
Shen, H.1
Laird, P.W.2
-
79
-
-
20244388526
-
Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 egfr or amplified egfr
-
Panousis C, Rayzman V, Johns T, Renner C, Liu Z, Cartwright G, et al. Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR. British journal of cancer. 2005; 92: 1069-77.
-
(2005)
British Journal of Cancer
, vol.92
, pp. 1069-1077
-
-
Panousis, C.1
Rayzman, V.2
Johns, T.3
Renner, C.4
Liu, Z.5
Cartwright, G.6
-
80
-
-
78449281478
-
Retrovirally engineered t‐cell‐based immunotherapy targeting type iii variant epidermal growth factor receptor, a glioma‐associated antigen
-
Ohno M, Natsume A, Ichiro Iwami K, Iwamizu H, Noritake K, Ito D, et al. Retrovirally engineered T‐cell‐based immunotherapy targeting type III variant epidermal growth factor receptor, a glioma‐associated antigen. Cancer science. 2010; 101: 2518-24.
-
(2010)
Cancer Science
, vol.101
, pp. 2518-2524
-
-
Ohno, M.1
Natsume, A.2
Ichiro Iwami, K.3
Iwamizu, H.4
Noritake, K.5
Ito, D.6
-
81
-
-
0025114687
-
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
-
Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proceedings of the National Academy of Sciences. 1990; 87: 8602-6.
-
(1990)
Proceedings of the National Academy of Sciences
, vol.87
, pp. 8602-8606
-
-
Sugawa, N.1
Ekstrand, A.J.2
James, C.D.3
Collins, V.P.4
-
82
-
-
0025111441
-
A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors
-
Yamazaki H, Ohba Y, Tamaoki N, Shibuya M. A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Cancer science. 1990; 81: 773-9.
-
(1990)
Cancer Science
, vol.81
, pp. 773-779
-
-
Yamazaki, H.1
Ohba, Y.2
Tamaoki, N.3
Shibuya, M.4
-
83
-
-
38449095735
-
The t-body approach: Redirecting t cells with antibody specificity. therapeutic antibodies
-
Eshhar Z. The T-body approach: redirecting T cells with antibody specificity. Therapeutic Antibodies. Springer; 2008. p. 329-42.
-
(2008)
Springer
, pp. 329-342
-
-
Eshhar, Z.1
-
84
-
-
84921473544
-
Target antigen density governs the efficacy of anti–cd20-cd28-cd3 ζ chimeric antigen receptor–modified effector cd8+ t cells
-
Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, et al. Target Antigen Density Governs the Efficacy of Anti–CD20-CD28-CD3 ζ Chimeric Antigen Receptor–Modified Effector CD8+ T Cells. The Journal of Immunology. 2015; 194: 911-20.
-
(2015)
The Journal of Immunology
, vol.194
, pp. 911-920
-
-
Watanabe, K.1
Terakura, S.2
Martens, A.C.3
Van Meerten, T.4
Uchiyama, S.5
Imai, M.6
-
85
-
-
84905460420
-
Therapeutic efficacy of an fc-enhanced tcr-like antibody to the intracellular wt1 oncoprotein
-
Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, et al. Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clinical Cancer Research. 2014; 20: 4036-46.
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 4036-4046
-
-
Veomett, N.1
Dao, T.2
Liu, H.3
Xiang, J.4
Pankov, D.5
Dubrovsky, L.6
-
86
-
-
77955553483
-
Wt1 peptide vaccinations induce cd4 and cd8 t cell immune responses in patients with mesothelioma and non-small cell lung cancer. Cancer immunology
-
Krug LM, Dao T, Brown AB, Maslak P, Travis W, Bekele S, et al. WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer. Cancer Immunology, Immunotherapy. 2010; 59: 1467-79.
-
(2010)
Immunotherapy
, vol.59
, pp. 1467-1479
-
-
Krug, L.M.1
Dao, T.2
Brown, A.B.3
Maslak, P.4
Travis, W.5
Bekele, S.6
-
87
-
-
79961175455
-
Wt1 peptide vaccine stabilized intractable ovarian cancer patient for one year: A case report
-
Dohi S, Ohno S, Ohno Y, Takakura M, Kyo S, Soma G-I, et al. WT1 peptide vaccine stabilized intractable ovarian cancer patient for one year: a case report. Anticancer research. 2011; 31: 2441-5.
-
(2011)
Anticancer Research
, vol.31
, pp. 2441-2445
-
-
Dohi, S.1
Ohno, S.2
Ohno, Y.3
Takakura, M.4
Kyo, S.5
Soma, G.-I.6
-
88
-
-
84995802682
-
Ngineered t cell receptor-mimic antibody,(tcrm) chimeric antigen receptor (car) t cells against the intracellular protein wilms tumor-1 (wt1) for treatment of hematologic and solid cancers
-
88. Rafiq S, Dao T, Liu C, Scheinberg DA, Brentjens RJ. Engineered T cell receptor-mimic antibody,(TCRm) chimeric antigen receptor (CAR) T cells against the intracellular protein Wilms tumor-1 (WT1) for treatment of hematologic and solid cancers. Blood. 2014; 124: 2155-.
-
(2014)
Blood
, vol.124
, pp. 2155
-
-
Rafiq, S.1
Dao, T.2
Liu, C.3
Scheinberg, D.A.4
Brentjens, R.J.5
-
89
-
-
84946494672
-
Affinity maturation of t-cell receptor-like antibodies for wilms tumor 1 peptide greatly enhances therapeutic potential
-
Zhao Q, Ahmed M, Tassev D, Hasan A, Kuo T, Guo H, et al. Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential. Leukemia. 2015.
-
(2015)
Leukemia
-
-
Zhao, Q.1
Ahmed, M.2
Tassev, D.3
Hasan, A.4
Kuo, T.5
Guo, H.6
-
90
-
-
84863727010
-
Mesothelin, a novel immunotherapy target for triple negative breast cancer
-
Tchou J, Wang L-C, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, et al. Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast cancer research and treatment. 2012; 133: 799-804.
-
(2012)
Breast Cancer Research and Treatment
, vol.133
, pp. 799-804
-
-
Tchou, J.1
Wang, L.-C.2
Selven, B.3
Zhang, H.4
Conejo-Garcia, J.5
Borghaei, H.6
-
91
-
-
84860506230
-
Mesothelin overexpression promotes mesothelioma cell invasion and mmp-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients
-
91. Servais EL, Colovos C, Rodriguez L, Bograd AJ, Nitadori J-i, Sima C, et al. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clinical Cancer Research. 2012; 18: 2478-89.
-
(2012)
Clinical Cancer Research
, vol.18
, pp. 2478-2489
-
-
Servais, E.L.1
Colovos, C.2
Rodriguez, L.3
Bograd, A.J.4
J-I, N.5
Sima, C.6
-
92
-
-
84859387466
-
Tissue and serum mesothelin are potential markers of neoplastic progression in barrett's associated esophageal adenocarcinoma
-
Rizk NP, Servais EL, Tang LH, Sima CS, Gerdes H, Fleisher M, et al. Tissue and serum mesothelin are potential markers of neoplastic progression in Barrett's associated esophageal adenocarcinoma. Cancer Epidemiology Biomarkers & Prevention. 2012; 21: 482-6.
-
(2012)
Cancer Epidemiology Biomarkers & Prevention
, vol.21
, pp. 482-486
-
-
Rizk, N.P.1
Servais, E.L.2
Tang, L.H.3
Sima, C.S.4
Gerdes, H.5
Fleisher, M.6
-
93
-
-
84896696863
-
Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma
-
Kachala SS, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, et al. Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. Clinical Cancer Research. 2014; 20: 1020-8.
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 1020-1028
-
-
Kachala, S.S.1
Bograd, A.J.2
Villena-Vargas, J.3
Suzuki, K.4
Servais, E.L.5
Kadota, K.6
-
94
-
-
84902124061
-
Discovery of mesothelin and exploiting it as a target for immunotherapy
-
Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer research. 2014; 74: 2907-12.
-
(2014)
Cancer Research
, vol.74
, pp. 2907-2912
-
-
Pastan, I.1
Hassan, R.2
-
95
-
-
84866740895
-
Dual targeting of erbb2 and muc1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling
-
Wilkie S, van Schalkwyk MC, Hobbs S, Davies DM, van der Stegen SJ, Pereira ACP, et al. Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling. Journal of clinical immunology. 2012; 32: 1059-70.
-
(2012)
Journal of Clinical Immunology
, vol.32
, pp. 1059-1070
-
-
Wilkie, S.1
Van Schalkwyk, M.C.2
Hobbs, S.3
Davies, D.M.4
Van Der Stegen, S.J.5
Pereira, A.C.P.6
-
96
-
-
84872196489
-
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered t cells
-
Kloss CC, Condomines M, Cartellieri M, Bachmann M, Sadelain M. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nature biotechnology. 2013; 31: 71-5.
-
(2013)
Nature Biotechnology
, vol.31
, pp. 71-75
-
-
Kloss, C.C.1
Condomines, M.2
Cartellieri, M.3
Bachmann, M.4
Sadelain, M.5
-
97
-
-
84942907010
-
Tuning sensitivity of car to egfr density limits recognition of normal tissue while maintaining potent antitumor activity
-
Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, et al. Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity. Cancer research. 2015; 75: 3505-18.
-
(2015)
Cancer Research
, vol.75
, pp. 3505-3518
-
-
Caruso, H.G.1
Hurton, L.V.2
Najjar, A.3
Rushworth, D.4
Ang, S.5
Olivares, S.6
-
98
-
-
84942885584
-
Affinity-tuned erbb2 or egfr chimeric antigen receptor t cells exhibit an increased therapeutic index against tumors in mice
-
Liu X, Jiang S, Fang C, Yang S, Olalere D, Pequignot EC, et al. Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice. Cancer research. 2015; 75: 3596-607.
-
(2015)
Cancer Research
, vol.75
, pp. 3596-3607
-
-
Liu, X.1
Jiang, S.2
Fang, C.3
Yang, S.4
Olalere, D.5
Pequignot, E.C.6
-
99
-
-
84862889768
-
Suicide gene therapy to increase the safety of chimeric antigen receptor-redirected t lymphocytes
-
Casucci M, Bondanza A. Suicide gene therapy to increase the safety of chimeric antigen receptor-redirected T lymphocytes. Journal of Cancer. 2011; 2: 378.
-
(2011)
Journal of Cancer
, vol.2
, pp. 378
-
-
Casucci, M.1
Bondanza, A.2
-
101
-
-
84908700977
-
The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor t cells
-
Gargett T, Brown MP. The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Frontiers in pharmacology. 2014; 5.
-
(2014)
Frontiers in Pharmacology
, pp. 5
-
-
Gargett, T.1
Brown, M.P.2
-
102
-
-
65349157330
-
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the tk007 trial): A non-randomised phase i–ii study
-
Ciceri F, Bonini C, Stanghellini MTL, Bondanza A, Traversari C, Salomoni M, et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study. The lancet oncology. 2009; 10: 489-500.
-
(2009)
The Lancet Oncology
, vol.10
, pp. 489-500
-
-
Ciceri, F.1
Bonini, C.2
Stanghellini, M.T.L.3
Bondanza, A.4
Traversari, C.5
Salomoni, M.6
-
104
-
-
84868294109
-
Tumor-infiltrating regulatory t cells delineated by upregulation of pd-1 and inhibitory receptors
-
Park HJ, Kusnadi A, Lee E-J, Kim WW, Cho BC, Lee IJ, et al. Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors. Cellular immunology. 2012; 278: 76-83.
-
(2012)
Cellular Immunology
, vol.278
, pp. 76-83
-
-
Park, H.J.1
Kusnadi, A.2
Lee, E.-J.3
Kim, W.W.4
Cho, B.C.5
Lee, I.J.6
-
106
-
-
84905993539
-
Multifactorial t-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor–transduced human t cells in solid tumors
-
Moon EK, Wang L-C, Dolfi DV, Wilson CB, Ranganathan R, Sun J, et al. Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor–transduced human T cells in solid tumors. Clinical Cancer Research. 2014; 20: 4262-73.
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 4262-4273
-
-
Moon, E.K.1
Wang, L.-C.2
Dolfi, D.V.3
Wilson, C.B.4
Ranganathan, R.5
Sun, J.6
-
107
-
-
84938600031
-
Chimeric antigen receptor t cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment
-
Beatty GL, Moon EK. Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment. Oncoimmunology. 2014; 3: e970027.
-
(2014)
Oncoimmunology
, vol.3
-
-
Beatty, G.L.1
Moon, E.K.2
-
108
-
-
33748749338
-
Immune resistance orchestrated by the tumor microenvironment
-
Gajewski TF, Meng Y, Blank C, Brown I, Kacha A, Kline J, et al. Immune resistance orchestrated by the tumor microenvironment. Immunological reviews. 2006; 213: 131-45.
-
(2006)
Immunological Reviews
, vol.213
, pp. 131-145
-
-
Gajewski, T.F.1
Meng, Y.2
Blank, C.3
Brown, I.4
Kacha, A.5
Kline, J.6
-
109
-
-
34249809103
-
Lack of b7 expression, not human leukocyte antigen expression, facilitates immune evasion by human malignant gliomas
-
Anderson RC, Anderson DE, Elder JB, Brown MD, Mandigo CE, Parsa AT, et al. Lack of B7 expression, not human leukocyte antigen expression, facilitates immune evasion by human malignant gliomas. Neurosurgery. 2007; 60: 1129-36.
-
(2007)
Neurosurgery
, vol.60
, pp. 1129-1136
-
-
Anderson, R.C.1
Anderson, D.E.2
Elder, J.B.3
Brown, M.D.4
Mandigo, C.E.5
Parsa, A.T.6
-
110
-
-
84870729573
-
Lymphatic endothelial cells induce tolerance via pd-l1 and lack of costimulation leading to high-level pd-1 expression on cd8 t cells
-
Tewalt EF, Cohen JN, Rouhani SJ, Guidi CJ, Qiao H, Fahl SP, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012; 120: 4772-82.
-
(2012)
Blood
, vol.120
, pp. 4772-4782
-
-
Tewalt, E.F.1
Cohen, J.N.2
Rouhani, S.J.3
Guidi, C.J.4
Qiao, H.5
Fahl, S.P.6
-
111
-
-
84861224393
-
Tumor pd-l1 co-stimulates primary human cd8+ cytotoxic t cells modified to express a pd1: Cd28 chimeric receptor
-
Prosser ME, Brown CE, Shami AF, Forman SJ, Jensen MC. Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1: CD28 chimeric receptor. Molecular immunology. 2012; 51: 263-72.
-
(2012)
Molecular Immunology
, vol.51
, pp. 263-272
-
-
Prosser, M.E.1
Brown, C.E.2
Shami, A.F.3
Forman, S.J.4
Jensen, M.C.5
-
112
-
-
72849125358
-
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
-
Santos AM, Jung J, Aziz N, Kissil JL, Puré E. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. The Journal of clinical investigation. 2009; 119: 3613.
-
(2009)
The Journal of Clinical Investigation
, vol.119
, pp. 3613
-
-
Santos, A.M.1
Jung, J.2
Aziz, N.3
Kissil, J.L.4
Puré, E.5
-
113
-
-
84881312673
-
Antitumor effects of chimeric receptor engineered human t cells directed to tumor stroma
-
Kakarla S, Chow KK, Mata M, Shaffer DR, Song X-T, Wu M-F, et al. Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Molecular Therapy. 2013; 21: 1611-20.
-
(2013)
Molecular Therapy
, vol.21
, pp. 1611-1620
-
-
Kakarla, S.1
Chow, K.K.2
Mata, M.3
Shaffer, D.R.4
Song, X.-T.5
Wu, M.-F.6
-
114
-
-
76649134465
-
Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers
-
Saadi A, Shannon NB, Lao-Sirieix P, O’Donovan M, Walker E, Clemons NJ, et al. Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proceedings of the National Academy of Sciences. 2010; 107: 2177-82.
-
(2010)
Proceedings of the National Academy of Sciences
, vol.107
, pp. 2177-2182
-
-
Saadi, A.1
Shannon, N.B.2
Lao-Sirieix, P.3
O’Donovan, M.4
Walker, E.5
Clemons, N.J.6
-
115
-
-
78149298209
-
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein–α
-
Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein–α. Science. 2010; 330: 827-30.
-
(2010)
Science
, vol.330
, pp. 827-830
-
-
Kraman, M.1
Bambrough, P.J.2
Arnold, J.N.3
Roberts, E.W.4
Magiera, L.5
Jones, J.O.6
-
116
-
-
84942919712
-
Tumor-promoting desmoplasia is disrupted by depleting fap-expressing stromal cells
-
2015: Canres
-
Lo A, Wang L-CS, Scholler J, Monslow J, Avery D, Newick K, et al. Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells. Cancer research. 2015: Canres.3041.2014.
-
(2014)
Cancer Research.
, pp. 3041
-
-
Lo, A.1
Wang, L.-C.2
Scholler, J.3
Monslow, J.4
Avery, D.5
Newick, K.6
-
117
-
-
84928759208
-
Adoptive cell transfer as personalized immunotherapy for human cancer
-
Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science. 2015; 348: 62-8.
-
(2015)
Science
, vol.348
, pp. 62-68
-
-
Rosenberg, S.A.1
Restifo, N.P.2
-
118
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015; 348: 69-74.
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
119
-
-
84954548519
-
Oncolytic virus expressing rantes and il-15 enhances function of car-modified t cells in solid tumors
-
Nishio N, Dotti G. Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors. Oncoimmunology. 2015; 4: e988098.
-
(2015)
Oncoimmunology
, pp. 4
-
-
Nishio, N.1
Dotti, G.2
|