-
2
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
-
Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 1993;90(2):720-4
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.2
, pp. 720-724
-
-
Eshhar, Z.1
Waks, T.2
Gross, G.3
Schindler, D.G.4
-
3
-
-
79955517235
-
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
-
Savoldo B, Ramos CA, Liu E, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest 2011;121(5):1822-6
-
(2011)
J Clin Invest
, vol.121
, Issue.5
, pp. 1822-1826
-
-
Savoldo, B.1
Ramos, C.A.2
Liu, E.3
-
4
-
-
0028902765
-
Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes
-
Brocker T, Karjalainen K. Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 1995;181(5):1653-9
-
(1995)
J Exp Med
, vol.181
, Issue.5
, pp. 1653-1659
-
-
Brocker, T.1
Karjalainen, K.2
-
5
-
-
0034283741
-
Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells
-
Brocker T. Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells. Blood 2000;96(5):1999-2001
-
(2000)
Blood
, vol.96
, Issue.5
, pp. 1999-2001
-
-
Brocker, T.1
-
6
-
-
0032531091
-
Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
-
Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 1998;161(6):2791-7
-
(1998)
J Immunol
, vol.161
, Issue.6
, pp. 2791-2797
-
-
Finney, H.M.1
Lawson, A.D.2
Bebbington, C.R.3
Weir, A.N.4
-
7
-
-
0036137615
-
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
-
Maher J, Brentjens RJ, Gunset G, et al. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol 2002;20(1):70-5
-
(2002)
Nat Biotechnol
, vol.20
, Issue.1
, pp. 70-75
-
-
Maher, J.1
Brentjens, R.J.2
Gunset, G.3
-
8
-
-
33845294816
-
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
-
Kowolik CM, Topp MS, Gonzalez S, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res 2006;66(22):10995-1004
-
(2006)
Cancer Res
, vol.66
, Issue.22
, pp. 10995-11004
-
-
Kowolik, C.M.1
Topp, M.S.2
Gonzalez, S.3
-
9
-
-
3042551216
-
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
-
Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 2004;18(4):676-84
-
(2004)
Leukemia
, vol.18
, Issue.4
, pp. 676-684
-
-
Imai, C.1
Mihara, K.2
Andreansky, M.3
-
10
-
-
84856071702
-
CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
-
Song DG, Ye Q, Poussin M, et al. CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. Blood 2012;119(3):696-706
-
(2012)
Blood
, vol.119
, Issue.3
, pp. 696-706
-
-
Song, D.G.1
Ye, Q.2
Poussin, M.3
-
11
-
-
84905996839
-
ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
-
Guedan S, Chen X, Madar A, et al. ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells. Blood 2014;124(7):1070-80
-
(2014)
Blood
, vol.124
, Issue.7
, pp. 1070-1080
-
-
Guedan, S.1
Chen, X.2
Madar, A.3
-
12
-
-
0347994955
-
Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
-
Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 2004;172(1):104-13
-
(2004)
J Immunol
, vol.172
, Issue.1
, pp. 104-113
-
-
Finney, H.M.1
Akbar, A.N.2
Lawson, A.D.3
-
13
-
-
27244432745
-
Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
-
Yazawa N, Hamaguchi Y, Poe JC, Tedder TF. Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proc Natl Acad Sci USA 2005;102(42):15178-83
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.42
, pp. 15178-15183
-
-
Yazawa, N.1
Hamaguchi, Y.2
Poe, J.C.3
Tedder, T.F.4
-
14
-
-
34848842554
-
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
-
Brentjens RJ, Santos E, Nikhamin Y, et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res 2007;13(18 Pt 1):5426-35
-
(2007)
Clin Cancer Res
, vol.13
, Issue.18
, pp. 5426-5435
-
-
Brentjens, R.J.1
Santos, E.2
Nikhamin, Y.3
-
15
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
Kochenderfer JN, Wilson WH, Janik JE, et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 2010;116(20):4099-102
-
(2010)
Blood
, vol.116
, Issue.20
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
Wilson, W.H.2
Janik, J.E.3
-
16
-
-
70350726110
-
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
-
Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther 2009;17(8):1453-64
-
(2009)
Mol Ther
, vol.17
, Issue.8
, pp. 1453-1464
-
-
Milone, M.C.1
Fish, J.D.2
Carpenito, C.3
-
17
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
-
Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 2012;119(12):2709-20
-
(2012)
Blood
, vol.119
, Issue.12
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Feldman, S.A.3
-
18
-
-
84907293786
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous t cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous t cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 2014
-
(2014)
J Clin Oncol
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Kassim, S.H.3
-
19
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 2011;3(95):95ra73
-
(2011)
Sci Transl Med
, vol.3
, Issue.95
, pp. 95ra73
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
-
20
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365(8):725-33
-
(2011)
N Engl J Med
, vol.365
, Issue.8
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
-
21
-
-
84877666359
-
How do CARs work?: Early insights from recent clinical studies targeting CD19
-
Davila ML, Brentjens R, Wang X, et al. How do CARs work?: early insights from recent clinical studies targeting CD19. Oncoimmunology 2012;1(9):1577-83
-
(2012)
Oncoimmunology
, vol.1
, Issue.9
, pp. 1577-1583
-
-
Davila, M.L.1
Brentjens, R.2
Wang, X.3
-
22
-
-
84897569379
-
Chimeric antigen receptor modified T cells directed against CD19 (CTL019 cells) have long-term persistence and induce durable responses in relapsed, refractory CLL
-
Porter DL, Kalos M, Frey NV, et al. Chimeric antigen receptor modified T cells directed against CD19 (CTL019 cells) have long-term persistence and induce durable responses in relapsed, refractory CLL. Blood 2013;122(21):4162
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 4162
-
-
Porter, D.L.1
Kalos, M.2
Frey, N.V.3
-
23
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 2011;118(18):4817-28
-
(2011)
Blood
, vol.118
, Issue.18
, pp. 4817-4828
-
-
Brentjens, R.J.1
Riviere, I.2
Park, J.H.3
-
24
-
-
77950480974
-
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase i clinical trial
-
Brentjens R, Yeh R, Bernal Y, et al. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther 2010;18(4):666-8
-
(2010)
Mol Ther
, vol.18
, Issue.4
, pp. 666-668
-
-
Brentjens, R.1
Yeh, R.2
Bernal, Y.3
-
25
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med 2014;371(3):213-23
-
(2014)
N Engl J Med
, vol.371
, Issue.3
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
-
26
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370(11):997-1007
-
(2014)
N Engl J Med
, vol.370
, Issue.11
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
-
27
-
-
84876005284
-
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
-
Brentjens RJ, Davila ML, Riviere I, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013;5(177):177ra38
-
(2013)
Sci Transl Med
, vol.5
, Issue.177
, pp. 177ra38
-
-
Brentjens, R.J.1
Davila, M.L.2
Riviere, I.3
-
28
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Feb 19
-
Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 2014 Feb 19 6(224):224ra25
-
(2014)
Sci Transl Med
, vol.6
, Issue.224
, pp. 224ra25
-
-
Davila, M.L.1
Riviere, I.2
Wang, X.3
-
29
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013;368(16):1509-18
-
(2013)
N Engl J Med
, vol.368
, Issue.16
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
-
30
-
-
33846869976
-
Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); An MRC UKALL12/ECOG 2993 study
-
Fielding AK, Richards SM, Chopra R, et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 2007;109(3):944-50
-
(2007)
Blood
, vol.109
, Issue.3
, pp. 944-950
-
-
Fielding, A.K.1
Richards, S.M.2
Chopra, R.3
-
31
-
-
34548136113
-
Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial
-
Tavernier E, Boiron JM, Huguet F, et al. Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial. Leukemia 2007;21(9):1907-14
-
(2007)
Leukemia
, vol.21
, Issue.9
, pp. 1907-1914
-
-
Tavernier, E.1
Boiron, J.M.2
Huguet, F.3
-
32
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp MS, Kufer P, Gokbuget N, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011;29(18):2493-8
-
(2011)
J Clin Oncol
, vol.29
, Issue.18
, pp. 2493-2498
-
-
Topp, M.S.1
Kufer, P.2
Gokbuget, N.3
-
33
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014;371(16):1507-17
-
(2014)
N Engl J Med
, vol.371
, Issue.16
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
-
34
-
-
84916895684
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
-
[Epub ahead of print]
-
Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 2014. [Epub ahead of print]
-
(2014)
Lancet
-
-
Lee, D.W.1
Kochenderfer, J.N.2
Stetler-Stevenson, M.3
-
35
-
-
84897568616
-
Managing cytokine release syndrome associated with novel T cell-engaging therapies
-
Maude SL, Barrett D, Teachey DT, Grupp SA. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J 2014;20(2):119-22
-
(2014)
Cancer J
, vol.20
, Issue.2
, pp. 119-122
-
-
Maude, S.L.1
Barrett, D.2
Teachey, D.T.3
Grupp, S.A.4
-
36
-
-
84891832317
-
Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells
-
Xu XJ, Tang YM. Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells. Cancer Lett 2014;343(2):172-8
-
(2014)
Cancer Lett
, vol.343
, Issue.2
, pp. 172-178
-
-
Xu, X.J.1
Tang, Y.M.2
-
37
-
-
84904097189
-
Current concepts in the diagnosis and management of cytokine release syndrome
-
Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood 2014;124(2):188-95
-
(2014)
Blood
, vol.124
, Issue.2
, pp. 188-195
-
-
Lee, D.W.1
Gardner, R.2
Porter, D.L.3
-
38
-
-
80052358980
-
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
-
Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011;121(9):3375-83
-
(2011)
J Clin Invest
, vol.121
, Issue.9
, pp. 3375-3383
-
-
Jones, S.A.1
Scheller, J.2
Rose-John, S.3
-
39
-
-
0034960582
-
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
-
Hurst SM, Wilkinson TS, McLoughlin RM, et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001;14(6):705-14
-
(2001)
Immunity
, vol.14
, Issue.6
, pp. 705-714
-
-
Hurst, S.M.1
Wilkinson, T.S.2
McLoughlin, R.M.3
-
40
-
-
0033080801
-
C-reactive protein: A physiological activator of interleukin 6 receptor shedding
-
Jones SA, Novick D, Horiuchi S, et al. C-reactive protein: a physiological activator of interleukin 6 receptor shedding. J Exp Med 1999;189(3):599-604
-
(1999)
J Exp Med
, vol.189
, Issue.3
, pp. 599-604
-
-
Jones, S.A.1
Novick, D.2
Horiuchi, S.3
-
41
-
-
0033214233
-
Primary refractory and relapsed adult acute lymphoblastic leukemia: Characteristics, treatment results, and prognosis with salvage therapy
-
Thomas DA, Kantarjian H, Smith TL, et al. Primary refractory and relapsed adult acute lymphoblastic leukemia: characteristics, treatment results, and prognosis with salvage therapy. Cancer 1999;86(7):1216-30
-
(1999)
Cancer
, vol.86
, Issue.7
, pp. 1216-1230
-
-
Thomas, D.A.1
Kantarjian, H.2
Smith, T.L.3
-
42
-
-
84872508758
-
T Cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: Long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease
-
Goldberg JD, Linker A, Kuk D, et al. T Cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biol Blood Marrow Transplant 2013;19(2):208-13
-
(2013)
Biol Blood Marrow Transplant
, vol.19
, Issue.2
, pp. 208-213
-
-
Goldberg, J.D.1
Linker, A.2
Kuk, D.3
-
43
-
-
77950664722
-
Outcome after relapse of acute lymphoblastic leukemia in adult patients included in four consecutive risk-adapted trials by the PETHEMA Study Group
-
Oriol A, Vives S, Hernandez-Rivas JM, et al. Outcome after relapse of acute lymphoblastic leukemia in adult patients included in four consecutive risk-adapted trials by the PETHEMA Study Group. Haematologica 2010;95(4):589-96
-
(2010)
Haematologica
, vol.95
, Issue.4
, pp. 589-596
-
-
Oriol, A.1
Vives, S.2
Hernandez-Rivas, J.M.3
-
44
-
-
76649132640
-
Challenges in the frontline treatment of patients with chronic lymphocytic leukemia
-
Lamanna N. Challenges in the frontline treatment of patients with chronic lymphocytic leukemia. Curr Hematol Malig Rep 2010;5(1):45-51
-
(2010)
Curr Hematol Malig Rep
, vol.5
, Issue.1
, pp. 45-51
-
-
Lamanna, N.1
-
45
-
-
84876050411
-
CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia
-
Davila ML, Kloss CC, Gunset G, Sadelain M. CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. PLoS One 2013;8(4):e61338
-
(2013)
PLoS One
, vol.8
, Issue.4
, pp. e61338
-
-
Davila, M.L.1
Kloss, C.C.2
Gunset, G.3
Sadelain, M.4
-
46
-
-
84858759305
-
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
-
Pegram HJ, Lee JC, Hayman EG, et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 2012;119(18):4133-41
-
(2012)
Blood
, vol.119
, Issue.18
, pp. 4133-4141
-
-
Pegram, H.J.1
Lee, J.C.2
Hayman, E.G.3
-
47
-
-
77949891071
-
Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells
-
Cheadle EJ, Hawkins RE, Batha H, et al. Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells. J Immunol 2010;184(4):1885-96
-
(2010)
J Immunol
, vol.184
, Issue.4
, pp. 1885-1896
-
-
Cheadle, E.J.1
Hawkins, R.E.2
Batha, H.3
-
48
-
-
76249116978
-
Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
-
James SE, Orgun NN, Tedder TF, et al. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood 2009;114(27):5454-63
-
(2009)
Blood
, vol.114
, Issue.27
, pp. 5454-5463
-
-
James, S.E.1
Orgun, N.N.2
Tedder, T.F.3
-
49
-
-
84899722959
-
Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia
-
Gassner FJ, Zaborsky N, Neureiter D, et al. Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia. Haematologica 2014;99(5):67-9
-
(2014)
Haematologica
, vol.99
, Issue.5
, pp. 67-69
-
-
Gassner, F.J.1
Zaborsky, N.2
Neureiter, D.3
-
50
-
-
84899656300
-
Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies
-
Davila ML, Bouhassira DC, Park JH, et al. Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies. Int J Hematol 2014;99(4):361-71
-
(2014)
Int J Hematol
, vol.99
, Issue.4
, pp. 361-371
-
-
Davila, M.L.1
Bouhassira, D.C.2
Park, J.H.3
-
51
-
-
84923077706
-
Aphasia as a complication of CD19-targeted chimeric antigen receptor immunotherapy (S52.006)
-
S52.006
-
Kranick S, Phan G, Kochenderfer J, et al. Aphasia as a complication Of CD19-targeted chimeric antigen receptor immunotherapy (S52.006). Neurology 2014;82(10 Suppl):S52.006
-
(2014)
Neurology
, vol.82
, Issue.10
-
-
Kranick, S.1
Phan, G.2
Kochenderfer, J.3
-
52
-
-
84882782587
-
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
-
Teachey DT, Rheingold SR, Maude SL, et al. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood 2013;121(26):5154-7
-
(2013)
Blood
, vol.121
, Issue.26
, pp. 5154-5157
-
-
Teachey, D.T.1
Rheingold, S.R.2
Maude, S.L.3
-
53
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006;355(10):1018-28
-
(2006)
N Engl J Med
, vol.355
, Issue.10
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
-
54
-
-
84875716409
-
High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia
-
O'Brien S, Schiller G, Lister J, et al. High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia. J Clin Oncol 2013;31(6):676-83
-
(2013)
J Clin Oncol
, vol.31
, Issue.6
, pp. 676-683
-
-
O'Brien, S.1
Schiller, G.2
Lister, J.3
-
55
-
-
33646337195
-
Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
-
Jeha S, Gaynon PS, Razzouk BI, et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. J Clin Oncol 2006;24(12):1917-23
-
(2006)
J Clin Oncol
, vol.24
, Issue.12
, pp. 1917-1923
-
-
Jeha, S.1
Gaynon, P.S.2
Razzouk, B.I.3
-
56
-
-
84916639631
-
Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
-
Topp MS, Gokbuget N, Zugmaier G, et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol 2014;32(36):4134-40
-
(2014)
J Clin Oncol
, vol.32
, Issue.36
, pp. 4134-4140
-
-
Topp, M.S.1
Gokbuget, N.2
Zugmaier, G.3
-
57
-
-
63649112916
-
Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
-
Hollyman D, Stefanski J, Przybylowski M, et al. Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J Immunother 2009;32(2):169-80
-
(2009)
J Immunother
, vol.32
, Issue.2
, pp. 169-180
-
-
Hollyman, D.1
Stefanski, J.2
Przybylowski, M.3
-
58
-
-
30444437486
-
Treatment of acute lymphoblastic leukemia
-
Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354(2):166-78
-
(2006)
N Engl J Med
, vol.354
, Issue.2
, pp. 166-178
-
-
Pui, C.H.1
Evans, W.E.2
-
59
-
-
84885991395
-
Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: Identifying a window of therapeutic opportunity?
-
van der Stegen SJ, Davies DM, Wilkie S, et al. Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity? J Immunol 2013;191(9):4589-98
-
(2013)
J Immunol
, vol.191
, Issue.9
, pp. 4589-4598
-
-
Van Der Stegen, S.J.1
Davies, D.M.2
Wilkie, S.3
-
60
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto-and transcostimulation, resulting in potent tumor rejection
-
Stephan MT, Ponomarev V, Brentjens RJ, et al. T cell-encoded CD80 and 4-1BBL induce auto-and transcostimulation, resulting in potent tumor rejection. Nat Med 2007;13(12):1440-9
-
(2007)
Nat Med
, vol.13
, Issue.12
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
-
61
-
-
84858758766
-
Adoptive immunotherapy for cancer: Harnessing the T cell response
-
Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012;12(4):269-81
-
(2012)
Nat Rev Immunol
, vol.12
, Issue.4
, pp. 269-281
-
-
Restifo, N.P.1
Dudley, M.E.2
Rosenberg, S.A.3
-
62
-
-
84890117209
-
Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation"
-
Hombach AA, Rappl G, Abken H. Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation". Mol Ther 2013;21(12):2268-77
-
(2013)
Mol Ther
, vol.21
, Issue.12
, pp. 2268-2277
-
-
Hombach, A.A.1
Rappl, G.2
Abken, H.3
-
63
-
-
84897565985
-
Anti-CD19 chimeric antigen receptor (CAR) T cells produce complete responses with acceptable toxicity but without chronic B-cell aplasia in children with relapsed or refractory acute lymphoblastic leukemia (ALL) even after allogeneic hematopoietic stem cell transplantation (HSCT)
-
Lee DW, Shah NN, Stetler-Stevenson M, et al. Anti-CD19 chimeric antigen receptor (CAR) T cells produce complete responses with acceptable toxicity but without chronic B-cell aplasia in children with relapsed or refractory acute lymphoblastic leukemia (ALL) even after allogeneic hematopoietic stem cell transplantation (HSCT). Blood 2013;122(21):68
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 68
-
-
Lee, D.W.1
Shah, N.N.2
Stetler-Stevenson, M.3
-
64
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010;18(4):843-51
-
(2010)
Mol Ther
, vol.18
, Issue.4
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
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