Autophagy in disease

Methods in Molecular Biology

Volumn 648, Issue , 2010, Pages 79-92

  Mijaljica, Dalibor ^a   Prescott, Mark ^a   Devenish, Rodney J ^a  

^a NONE

Author keywords

Autophagy; Degradation; Disease; Pathophysiology; Stress

Indexed keywords

AUTOPHAGY RELATED PROTEIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN;

AUTOPHAGY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CROHN DISEASE; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; GENERAL ASPECTS OF DISEASE; HUMAN; INFECTION; LIVER DISEASE; LYSOSOME MEMBRANE; MACROAUTOPHAGY; MALIGNANT NEOPLASM; MICROAUTOPHAGY; MUSCLE DISEASE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; ANIMAL; HEALTH; REVIEW;

ANIMALS; AUTOPHAGY; DISEASE; HEALTH; HUMANS;

EID: 79952014150     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-756-3_5     Document Type: Chapter

References (67)

1. Huang J, Klionsky DJ (2007) Autophagy and human disease. Cell Cycle 6:1837–1849
2. Eskelinen EL, Saftig P (2009) Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793:664–673
3. Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27–42
4. Kundu M, Thompson CB (2008) Autophagy: Basic principles and relevance to disease. Annu Rev Pathol 3:427–455
5. Colombo MI (2007) Autophagy: A pathogen driven process. IUBMB Life 59:238–242
6. Mizushima N, Klionsky DJ (2007) Protein turnover via autophagy: Implications for metabolism. Annu Rev Nutr 27:19–40
7. Cecconi F, Levine B (2008) The role of autophagy in mammalian development: Cell makeover rather than cell death. Dev Cell 15:344–357
8. Hussey S, Terebiznik MR, Jones NL (2008) Autophagy: Healthy eating and self digestion for gastroenterologists. J Pediatr Gastroenterol Nutr 46:496–506
9. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069–1075
10. Uchiyama Y, Shibata M, Koike M, Yoshimura K, Sasaki M (2008) Autophagy-physiology and pathophysiology. Histochem Cell Biol 129:407–420
11. van der Vaart A, Mari M, Reggiori F (2008) A picky eater: Exploring the mechanisms of selective autophagy in human pathologies. Traffic 9:281–289
12. Yin XM, Ding WX, Gao W (2008) Autophagy in the liver. Hepatology 47:1773–1785
13. Yu L, Strandberg L, Leonardo MJ (2008) The selectivity of autophagy and its role in cell death and survival. Autophagy 4:567–573
14. Todde V, Veenhuis M, van der Klei IJ (2009) Autophagy: Principles and significance in health and disease. Biochim Biophys Acta 1792:3–13
15. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT (2008) Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182: 685–701
16. Klionsky DJ (2007) Autophagy: From phe-nomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8:931–937
17. Xie Z, Klionsky DJ (2007) Autophagosome formation: Core machinery and adaptations. Nat Cell Biol 9:1102–1109
18. Meijer WH, van der Klei IJ, Veenhuis M, Kiel JA (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3:106–116
19. Yorimitsu T, Klionsky DJ (2005) Autophagy: Molecular machinery for self-eating. Cell Death Differ 12(Suppl 2):1542–1552
20. Suzuki K, Ohsumi Y (2007) Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 581:2156–2161
21. Yang YP, Liang ZQ, Gu ZL, Qin ZH (2005) Molecular mechanism and regulation of autophagy. Acta Pharmacol Sin 26: 1421–1434
22. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471–484
23. Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO (2009) Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136:521–534
24. Kadowaki M, Karim MR, Carpi A, Miotto G (2006) Nutrient control of macroautophagy in mammalian cells. Mol Aspects Med 27:426–443
25. Meijer AJ, Codogno P (2006) Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med 27:411–425
26. Dunn WA Jr, Cregg JM, Kiel JA, van der Klei IJ, Oku M, Sakai Y, Sibirny AA, Stasyk OV, Veenhuis M (2005) Pexophagy: The selective autophagy of peroxisomes. Autophagy 1:75–83
27. Krick R, Muehe Y, Prick T, Bremer S, Schlotterhose P, Eskelinen EL, Millen J, Goldfarb DS, Thumm M (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol Biol Cell 19:4492–4505
28. Kiššová I, Salin B, Schaeffer J, Bhatia S, Manon S, Camougrand N (2007) Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy 3:329–336
29. Dubouloz F, Deloche O, Wanke V, Cameroni E, De Virgilio C (2005) The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19:15–26
30. Uttenweiler A, Schwarz H, Neumann H, Mayer A (2007) The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Mol Biol Cell 18:166–175
31. Kaushik S, Cuervo AM (2008) Chaperone-mediated autophagy. Meth Mol Biol 445:227–244
32. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672–676
33. Jin S (2006) Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2:80–84
34. Mathew R, Karantza-Wadsworth V, White E (2007) Role of autophagy in cancer. Nat Rev Cancer 7:961–967
35. Kroemer G, Levine B (2008) Autophagic cell death: The story of a misnomer. Nat Rev Mol Cell Biol 9:1004–1010
36. Bialik S, Kimchi A (2008) Autophagy and tumor suppression: Recent advances in understanding the link between autophagic cell death pathways and tumor development. Adv Exp Med Biol 615:177–200
37. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441:880–884
38. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441:885–889
39. Ventruti A, Cuervo AM (2007) Autophagy and neurodegeneration. Curr Neurol Neurosci Rep 7:443–451
40. Winslow AR, Rubinsztein DC (2008) Autophagy in neurodegeneration and development. Biochim Biophys Acta 1782: 723–729
41. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, Cataldo AM, Nixon RA (2005) Macroautophagy-a novel Beta-amyloid pep-tide-generating pathway activated in Alzheimer’s disease. J Cell Biol 171:87–98
42. Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y (2008) Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172:454–469
43. Yue Z, Friedman L, Komatsu M, Tanaka K (2009) The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta 1793:1496–1507
44. Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC (2006) Aggregate-prone proteins are cleared from the cytosol by autophagy: Therapeutic implications. Curr Top Dev Biol 76:89–101
45. Nishino I (2003) Autophagic vacuolar myopathies. Curr Neurol Neurosci Rep 3:64–69
46. Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, Mora M, Riggs JE, Oh SJ, Koga Y, Sue CM, Yamamoto A, Murakami N, Shanske S, Byrne E, Bonilla E, Nonaka I, DiMauro S, Hirano M (2000) Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon dis-ease). Nature 406:906–910
47. Martinet W, Knaapen MW, Kockx MM, De Meyer GR (2007) Autophagy in cardiovascular disease. Trends Mol Med 13:482–491
48. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13:619–624
49. Martinet W, De Meyer GR (2009) Autophagy in atherosclerosis: A cell survival and death phenomenon with therapeutic potential. Circ Res 104:304–317
50. Gannagé M, Münz C (2009) Macroautophagy in immunity and tolerance. Traffic 10:616–620
51. Münz C (2009) Enhancing immunity through autophagy. Annu Rev Immunol 27:423–449
52. Levine B, Deretic V (2007) Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 7:767–777
53. Orvedahl A, Levine B (2009) Eating the enemy within: Autophagy in infectious diseases. Cell Death Differ 16:57–69
54. Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Häsler R, Sipos B, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207–211
55. Massey DC, Parkes M (2007) Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn’s disease. Autophagy 3:649–651
56. Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ (2008) Impaired autophagy of an intracellular pathogen induced by a Crohn’s disease associated ATG16L1 variant. PLoS ONE 3:e3391
57. Zhang H, Massey D, Tremelling M, Parkes M (2008) Genetics of inflammatory bowel disease: Clues to pathogenesis. Br Med Bull 87:17–30
58. Meijer AJ, Codogno P (2008) Autophagy: A sweet process in diabetes. Cell Metab 8:275–276
59. Codogno P, Meijer AJ (2005) Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 12(Suppl 2):1509–1518
60. Russell SJ, Kahn CR (2007) Endocrine regulation of ageing. Nat Rev Mol Cell Biol 8:681–91
61. Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH (2007) Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56:930–939
62. Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS (2008) Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperg-lycemia. Cell Metab 8:318–324
63. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H (2008) Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8:325–332
64. Cuervo AM (2004) Autophagy: In sickness and in health. Trends Cell Biol 14:70–77
65. Yen WL, Klionsky DJ (2008) How to live long and prosper: Autophagy, mitochondria, and aging. Physiology (Bethesda) 23: 248–262
66. Cuervo AM (2008) Autophagy and aging: Keeping that old broom working. Trends Genet 24:604–612
67. Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ (2007) Potential therapeutic applications of autophagy. Nat Rev Drug Discov 6:304–312