SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress

Stem Cells

Volumn 32, Issue 5, 2014, Pages 1183-1194

  Ou, Xuan ^a   Lee, Man Ryul ^a   Huang, Xinxin ^a   Messina Graham, Steven ^a   Broxmeyer, Hal E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Autophagy; Cell culture; Cell signaling; Embryonic stem cells; Oxidative stress; Sirt1

Indexed keywords

3 METHYLADENINE; BECLIN 1; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P70; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; SIRTUIN 1; 3-METHYLADENINE; ADENINE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; OXIDIZING AGENT; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN TISSUE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REGULATORY MECHANISM; STAINING; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CELL LINE; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENINE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; EMBRYONIC STEM CELLS; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MITOCHONDRIA; OXIDANTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIRTUIN 1; TOR SERINE-THREONINE KINASES;

EID: 84898031861     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1641     Document Type: Article

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