The glycine-alanine dipeptide repeat from C9 or f72 hexanucleotide expansions forms toxic amyloids possessing cell-to-cell transmission properties

Journal of Biological Chemistry

Volumn 291, Issue 10, 2016, Pages 4903-4911

  Chang, Yu Jen ^a   Jeng, U Ser ^c,d   Chiang, Ya Ling ^b,d   Hwang, Ing Shouh ^b,d   Chen, Yun Ru ^a  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b INSTITUTE OF PHYSICS   (Taiwan)

^c NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ATOMIC FORCE MICROSCOPY; CELLS; GLYCOPROTEINS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; NEURODEGENERATIVE DISEASES; PEPTIDES; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; X RAY SCATTERING;

ALANINE DIPEPTIDES; AMYOTROPHIC LATERAL SCLEROSIS; CELL TRANSMISSIONS; CYTOPLASMIC INCLUSION; NEUROBLASTOMA CELLS; NEUROTOXICITY; NON-CODING REGION; TOXICITY PROPERTIES;

CYTOLOGY;

ALANINE; AMYLOID; CYTOSINE; DIPEPTIDE; GLYCINE; GUANINE; C9ORF72 PROTEIN, HUMAN; PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; BETA SHEET; BRAIN; C9ORF72 GENE; CONTROLLED STUDY; CYTOPLASM; DIPEPTIDE REPEAT; FRONTOTEMPORAL DEMENTIA; GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEUROBLASTOMA CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SPINAL CORD; CHEMISTRY; DRUG EFFECTS; METABOLISM; NERVE CELL; TRINUCLEOTIDE REPEAT; TUMOR CELL LINE;

ALANINE; AMYLOID; CELL LINE, TUMOR; DIPEPTIDES; GLYCINE; HUMANS; NEURONS; PROTEINS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84964692199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.694273     Document Type: Article

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