Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing

Acta Neuropathologica

Volumn 130, Issue 4, 2015, Pages 537-555

  Schludi, Martin H ^a,b   May, Stephanie ^a   Grässer, Friedrich A ^c   Rentzsch, Kristin ^a   Kremmer, Elisabeth ^a,b,d   Küpper, Clemens ^a,b,e   Klopstock, Thomas ^a,b,e   Ceballos Baumann, Andres ^g   Danek, Adrian ^g   Diehl Schmid, Janine ^g   Fassbender, Klaus ^g   Förstl, Hans ^g   Kornhuber, Johannes ^g   Otto, Markus ^g   Dieterich, Marianne ^g   Feuerecker, Regina ^g   Giese, Armin ^g   Klünemann, Hans ^g   Kurz, Alexander ^g   Levin, Johannes ^g   Lorenzl, Stefan ^g   Meyer, Thomas ^g   Nübling, Georg ^g   Roeber, Sigrun ^g   more..

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b Germany 3 Munich Cluster for Systems Neurology   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

^g Ludwig Maximilians University Munich ^*

Author keywords

ALS; C9orf72; DPR inclusions; FTLD; Neurotoxicity; Repeat disorders

Indexed keywords

DIPEPTIDE; DIPEPTIDE REPEAT PROTEIN; PROTEIN; UNC119 PROTEIN; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; REPETITIVE DNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNC119 PROTEIN, HUMAN;

ADULT; AGED; ANIMAL CELL; ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN STEM; C9ORF72 GENE; CELL INCLUSION; CELL STRESS; CELLULAR DISTRIBUTION; CEREBELLUM; CONTROLLED STUDY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GLIA; HETEROCHROMATIN; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; NERVE CELL; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; SPINAL CORD; TRANSCRIPTION TERMINATION; ANIMAL; BRAIN; COHORT ANALYSIS; COMPLICATION; GENETICS; METABOLISM; MIDDLE AGED; MOTOR NEURON DISEASE; PATHOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ANIMALS; BRAIN; CELL NUCLEOLUS; COHORT STUDIES; DNA REPEAT EXPANSION; FRONTOTEMPORAL LOBAR DEGENERATION; GENE SILENCING; HUMANS; INCLUSION BODIES; MIDDLE AGED; MOTOR NEURON DISEASE; NEUROGLIA; NEURONS; PROTEINS; RATS; SPINAL CORD;

EID: 84931463593     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1450-z     Document Type: Article

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