FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions

Acta Neuropathologica

Volumn 130, Issue 4, 2015, Pages 525-535

  Yang, Dejun ^a   Abdallah, Abbas ^a   Li, Zhaodong ^a,b   Lu, Yubing ^a   Almeida, Sandra ^a   Gao, Fen Biao ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ALS; DPR; Drosophila; FTD; Inclusion; Motor neuron; Notch; Poly(GA); Poly(GR); Poly(PR); RAN translation

Indexed keywords

DIPEPTIDE; DIPEPTIDE REPEAT PROTEIN; NOTCH RECEPTOR; POLY(GA) PROTEIN; POLY(GR) PROTEIN; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; PROTEIN; REPETITIVE DNA;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN CELL; CELL INCLUSION; CELL LOSS; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE INTERACTION; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MIDDLE FRONTAL GYRUS; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; START CODON; STOP CODON; TRANSGENIC DROSOPHILA; AGED; ANIMAL; CELL DEATH; DROSOPHILA; EYE; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MIDDLE AGED; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL; WING;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DEATH; DNA REPEAT EXPANSION; DROSOPHILA; EYE; FRONTOTEMPORAL DEMENTIA; HELA CELLS; HUMANS; INCLUSION BODIES; INDUCED PLURIPOTENT STEM CELLS; MIDDLE AGED; MOTOR ACTIVITY; NEURONS; PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WINGS, ANIMAL;

EID: 84942369550     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1448-6     Document Type: Article

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