The core of hepatitis C virus pathogenesis

Current Opinion in Virology

Volumn 17, Issue , 2016, Pages 66-73

  Kao, C Cheng ^a   Yi, Guanghui ^a   Huang, Hsuan Cheng ^b  

^a INDIANA UNIVERSITY   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; CORE PROTEIN; FAT DROPLET;

ADAPTIVE IMMUNITY; APOPTOSIS; ARTICLE; CELL CULTURE; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; FATTY LIVER; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INNATE IMMUNITY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRAL CLEARANCE; VIRUS GENOME; ANIMAL; CHEMISTRY; GENETICS; HEPACIVIRUS; IMMUNOLOGY; LIVER TUMOR; METABOLISM; MOUSE; PATHOGENICITY; VIROLOGY;

ANIMALS; CAPSID PROTEINS; CARCINOMA, HEPATOCELLULAR; GENOME, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MICE; VIRAL CORE PROTEINS;

EID: 84964647174     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2016.01.009     Document Type: Review

References (114)

1. Q.L. Choo, G. Kuo, A.J. Weiner, L.R. Overby, Bradley, and et al. Isolation of a cDNA derived from a blood-borne nonA-, nonB viral hepatitis genome Science 244 1989 359 362
2. J.P. Messina, I. Humphreys, A. Flaxman, A. Brown, G.S. Cooke, O.G. Pybus, and E. Barnes Global distribution and prevalence of hepatitis C virus genotypes Hepatology 61 2015 77 87
3. R.T. Cheung Acute HCV infection Clin Infect Dis 41 2005 S14 S17
4. L.B. Seeff Natural history of hepatitis C Hepatology 26 1997 21S 28S
5. A. Antonelli, S.M. Ferrari, D. Giuggioli, A.D. Domenicantonio, L. Ruffilli, and et al. Hepatitis C virus infection and type 1 and type 2 diabetes World J Diabetes 5 2014 586 600
6. J.-M. Pawlotsky New hepatitis C therapies: the toolbox, strategies, and challenges Gasteroenterology 146 2014 1176 1192
7. E. Lawitz, A. Mangia, D. Wyles, M. Rodriguez-Torres, T. Hassanein, and et al. Sofosbuvir for previously untreated chronic hepatitis C infection NEJM 368 2013 1878 1887
8. S. Zeuzem, G.M. Dusheiko, R. Salupere, A. Mangia, R. Flisiak, and et al. Sofosbuvir and ribavirin in HCV genotypes 2 and 3 NEJM 370 2014 1993 2001
9. I.M. Jacobson, S.C. Gordon, K.V. Kowdley, E.M. Yoshida, Rodriguez-Torres, and et al. Sofosbuvir for Hepatitis C genotype 2 or 3 in patients without treatment options NEJM 368 2013 1867 1877
10. D. Moradpour, and F. Penin Hepatitis C virus proteins: from structure to function Curr Top Microbiol Immunol 369 2013 113 142
11. S. Chinnaswamy, I. Yarbrough, S. Palaninathan, C.T. Ranjith Kumar, V. Vijayaraghavan, and et al. A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase J Biol Chem 283 2008 20535 20546
12. E. Santolini, G. Migliaccio, and N. La Monica Biosynthesis and biochemical properties of the hepatitis C virus core protein J Virol 68 1994 3631 3641
13. M.S. Afzal, K. Alsaleh, R. Frahat, S. Belouzard, A. Danneels, and et al. Regulation of core expression during the hepatitis C virus life cycle J Gen Virol 96 2015 311 321
14. V.N. Uversky Intrinsically disordered proteins from A to Z Int J Biochem Cell Biol 43 2011 1090 1103
15. S. Boni, J.P. Lavergne, and A. Cahour Hepatitis C virus core protein acts as a trans-modulating factor on internal translation initiation of the viral RNA J Biol Chem 280 2005 17737 17748
16. S. Lourenco, F. Costa, Desbargels, and A. Andrieu Hepatitis C virus internal ribosome entry site-mediated translation is mediated by cis-acting RNA elements and trans-acting viral factors FEBS J 275 2008 4179 4197
17. T. Shimoike, C. Koyana, K. Murakami, R. Suzuki, T. Matsura, and et al. Down-regulation of the internal ribosome entry site (IRE)-mediated translation of the hepatitis C virus: critical role of binding the stem-loop IIId domain of iRES and the viral core protein Virology 345 2006 434 445
18. N.K. Mohd-Ismail, L. Deng, S.K. Sukumaran, V.C. Hu, H. Hatta, and et al. The Hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1 J Virol 83 2009 9993 10006
19. R. Suzuki, Y. Matsuura, T. Suzuki, A. Ando, J. Chiba, and et al. Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted J Gen Virol 76 1995 53 61
20. F.J. Eng, J.L. Walewski, A.L. Klepper, S.L. Fishman, S.M. Desai, L.K. McMullan, M.J. Evans, Rice, and A.D. Branch Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis virus core protein isoforms J Virol 83 2009 3104 3114
21. S. Boulant, R. Montserret, R. Hope, M. Ratinier, P. Targett-Adams, J. Lavergne, F. Penin, and J. McLauchian Structural determinants that targets the hepatitis C virus Core protein to lipid droplets J Biol Chem 281 2006 22236 22247
22. S.L. Fishman, S.H. Factor, C. Balestrieri, X. Fan, A.M. DiBisceglie, S.M. Desai, G. Benson, and A.D. Branch Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma Cancer Prev Suscept 15 2009 3205 3213
23. T. Karamitros, A. Kakkanas, A. Katsoulidou, V. Sypsa, G. Dalagiorgous, and et al. Detection of specific antibodies to HCV-ARF/Core+1 protein in patients treated with pegylated interferon plus ribavirin J Viral Hepat 19 2012 182 188
24. J.L. Walewski, T.R. Keller, D.D. Stump, and A.D. Branch Evidence for a new Hepatitis C virus antigen encoded in an overlapping reading frame RNA 7 2001 710 721
25. I. Kotta-Loizou, N. Vassilaki, G. Pissas, A. Kakkanas, L. Bakiri, and et al. Hepatitis C virus Core +1/AFR protein decreases hepcidin transcription through an AP1 binding site J Gen Virol 94 2013 1528 1534
26. L.K. McMullan, A. Grakoui, M.J. Evans, K. Mihalik, M. Puig, and et al. Evidence for a functional RNA element in the hepatitis C virus core gene Proc Natl Acad Sci USA 104 2007 2879 2884
27. N. Vassilaki, P. Friebe, P. Meuleman, S. Kallis, A. Kaul, G. Paranhos-Baccala, G. Leroux-Roels, P. Mavromara, and R. Bartenschlager Role of the hepatitis C virus Core+1 open reading frame and core cis-acting RNA elements in viral translation and replication J Virol 82 2008 11503 11515
28. N. Ogata, H.J. Alter, R.H. Miller, and R.H. Purcell Nucleotide sequence and mutation rate of the H strain of hepatitis C virus Proc Natl Acad Sci USA 88 1991 3392 3396
29. N. Akuta, F. Suzuki, Y. Kawamura, H. Yatshuji, H. Sezaki, and et al. Amino acid substitutions in the hepatitis C virus Core region are important predictors of hepatocarcinogeneis Hepatology 46 2007 1357 1364
30. X. Tang, J. Wagoner, A. Negash, M. Austin, J. McLauchlan, and et al. Functional characterization of Core genes from patients with acute hepatitis J Infect Dis 201 2010 912 922
31. S. Khaliq, S. Jahan, and A. Pervaiz Sequence variability of HCV Core region: important predictors of HCV induced pathogenesis and viral production Infect Genet Evol 11 2011 543 556
32. C.W. Shepard, L. Finelli, and M. Alter Global epidemiology of hepatitis C virus infection Lancet Infect Dis 5 2005 558 567
33. J.T. Blackard, and K.E. Sherman Hepatitis C virus coinfection and superinfection J Infect Dis 195 2007 519 524
34. P.S. Pang, P.J. Planet, and J.S. Glenn The evolution of the major hepatitis C genotypes correlates with clinical response to interferon treatment PLoS One 4 2009 e6579
35. B. Roche, A. Coilly, Roque-Afonso Am, and D. Samuel Interferon-free hepatitis C virus treatment before and after liver transplantation: the role of drug resistance Viruses 7 2015 5155 5168
36. S. Bruno, A. Crosignani, P. Maisonneuve, S. Rossi, E. Silini, and et al. Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year perspective cohort study Hepatology 46 2007 1350 1356
37. S. Raimondi, S. Bruno, M.U. Mondelli, and P. Maisonneuve Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta analysis J Hepatol 50 2008 1142 1154
38. J.K. Mitchell, S.M. Lemon, and D.R. McGivern How do persistent infections with hepatitis C virus cause liver cancer Curr Opin Virol 14 2015 101 108
39. E.B. Tapper, and N.H. Afdhal Is 3 the new 1: perspectives on virology, natural history and treatment for hepatitis C genotype 3 J Viral Hepat 20 2013 669 677
40. G. Barba, F. Harper, T. Harada, M. Kohara, M. Goulinet, and et al. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets Proc Natl Acad Sci USA 84 1997 1200 1205
41. Y. Miyanari, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki, and et al. The lipid droplet is an important organelle for hepatitis C virus production Nat Cell Biol 9 2007 1089 1097
42. R.V. Farese, and T.C. Walther Lipid droplets finally get a little, R-E-S-P-E-C-T Cell 139 2009 855 860
43. J.M. Goodman Demonstrated and inferred metabolisms associated with cytosolic lipid droplets J Lipid Res 50 2009 2148 2156
44. R.B. Ray, and R. Ray Hepatitis c virus core protein: intriguing properties and functional relevance FEMS Microbiol Lett 202 2001 149 156
45. K. Koike Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies Clin Gastroenterol Hepatol 10 2005 S132 S135
46. K. Moriya, H. Fujie, Y. Shintani, H. Yotsuyanagi, T. Tsutsumi, and et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat Med 4 1998 1065 1067
47. K. Moriya, H. Yotsuyanagi, Y. Shintani, H. Fujie, K. Ishibashi, Y. Matsuura, T. Miyamura, and K. Koike Hepatitis C virus core protein induces hepatitis steatosis in transgenic mice J Gen Virol 78 1997 1527 1531
48. G. Perlemuter, A. Sabile, P. Letteron, G. Vona, A. Topilco, and et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model for viral-related steatosis FASEB J 16 2002 185 194
49. S.K. Kwofie, U. Schaefer, V.S. Sundararajan, V.B. Bajic, and A. Christoffelis HCVpro: hepatitis C virus protein interaction database Infect Genet Evol 11 2011 1971 1977
50. C.L. Borozan, J. Feld, J. Sun, L.L. Tannis, C. Coltescu, and et al. Hepatic gene expression discriminates responders and nonresponders in treatment of hepatitis C viral infection Gasteroenterology 128 2005 1437 1444
51. G.C. MacQuillan, C. Mamotte, W.D. Reed, G.P. Jeffrey, and et al. Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection J Med Virol 70 2003 219 227
52. N. Delheim, A. Sabile, Gajardo, P. Podevin, A. Abadie, and et al. Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus Core protein Oncogene 20 2001 5836 5845
53. V. Pazienza, S. Clément, P. Pugnale, S. Conzelmann, S. Pascarella, and et al. Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins Liver Int 29 2009 661 669
54. A. Banerjee, R.B. Ray, and R. Ray Oncogenic potential of hepatitis C virus proteins Viruses 2 2010 2108 2133
55. G. Waris, D.J. Felmlee, F. Negro, and A. Siddiqui Hepatitis C virus induces proteolytic cleavage of sterol regulatory binding proteins and stimulates their phosphorylation via oxidative stress J Virol 81 2007 8122 8130
56. R. Singaravelu, R. Chen, R.K. Lyn, D.M. Jones, S. O'Hara, and et al. Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis Hepatology 59 2014 98 108
57. Y. Wu, K. Chen, X. Liu, L. Huang, D. Zhao, and et al. SREBP-1 interacts with cMyc to enhance somatic cell reprogramming Stem cells 2015 10.1002/stem.2209
58. C. Jackel-Cram, L.A. Babuik, and Q. Liu Upregulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has stronger effects than genotype-1b core J Hepatol 46 2006 999 1008
59. K. Michels, E. Nemeth, T. Ganz, and B. Mehrad Hepcidin and host defense against infectious diseases PLoS Pathog 11 2015 e1004998
60. K. Miura, K. Taura, Y. Kodama, B. Schnabl, and D.A. Brenner Hepatitis C virus induced oxidative stress suppresses hepcidin expression through increased histone acetylase activity Hepatology 48 2008 1420 1429
61. 2-induced apoptosis by down regulating P14 expression via DNA methylation J Gen Virol 96 2015 822 832
62. T. Fukutomi, Y. Zhou, S. Kawai, H. Eguchi, J.R. Wand, and et al. Hepatitis C virus Core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression Hepatology 41 2005 1096 1105
63. H.F. Zhou, D. Nie, X. Cai, X. Shan, and et al. Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition Oncogene 33 2014 2826 2835
64. A. Kozomara, and S. Griffith-Jones miRBase: annotating high confidence microRNAs using deep sequencing data Nucleic Acid Res 42 2014 D68 D73
65. B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
66. Y. Gu, Y. Xu, L. Jiang, X. Cao, F. Liu, and et al. Differentially expressed microRNAs in Huh-7 cells expressing HCV core genotypes 3a or 1b: potential functions and downstream pathways Int J Mol Med 30 2012 374 382
67. T.M. Honda, T. Shimakami, R. Horii, T. Yamashita, and et al. MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells J Virol 87 2013 5270 5286
68. D. Liu, J. Wu, M. Liu, H. Yin, J. He, and et al. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells Biochem Biophys Res Commun 464 2015 1215 1221
69. S. Huang, Y. Xie, P. Chen, and L. Zhang HCV Core protein-induced down-regulation of micRNA-152 promoted aberrant proliferastion by regulating Wnt1 in HepG2 cells PLoS One 9 2014 e81730
70. H.C. Li, H.C. Ma, C.H. Yang, and S.Y. Lo Production and pathogenicity of hepatitis C virus core products World J Gasterolenterol 20 2014 7104 7122
71. C.L. Jopling, M. Yi, A.M. Lancaster, S.M. Lemon, and P. Sarnow Modulation of Hepatitis C virus RNA abundance by a liver-specific microRNA Science 309 2005 1577 1581
72. B. Fan, F.X. Reymond, G.D. Syu, S. Middleton, Yi, and et al. Heterogeneous ribonucleoprotein K (hnRNP K) binds miR-122, a mature liver-specific microRNA required for Hepatitis C virus replication Molec Cell Proteom M115 2015 050344
73. C. Esau, S. Davis, S.F. Murray, X.X. Yu, and S.K. Pandey MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 3 2005 87 98
74. S.M. Horner, and M. Gale Jr. Regulation of hepatic innate immunity by hepatitis C virus Nat Med 19 2013 879 888
75. L. Kui, and S.M. Lemon Innate immune responses in hepatitis C virus infection Semin Immunopathol 35 2013 53 72
76. B. Rehermann Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence J Clin Invest 119 2009 1745 1754
77. P. Metz, A. Reuter, S. Bender, and R. Bartenschlager Interferon-stimulated genes and their role in controlling hepatitis C virus J Hepatol 59 2013 1331 1341
78. M.T. Wong, and S.S. Chen Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection Cell Mol Immunol 2014 1025
79. M. Heim, D. Moradpour, and H.E. Blum Expression of the hepatitis C virus protein inhibits signal transduction through the Jak-STAT pathway J Virol 73 1999 8469 8475
80. A. Basu, K. Meyer, K.K. Lai, K. Saito, A.M. Di Bisceglie, and et al. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes Virology 349 2006 347 358
81. W. Lin, S.S. Kim, E. Yeung, Y. Kamegaya, J.T. Blackard, and et al. Hepatitis C virus Core protein blocks interferon signaling by interaction with the STAT SH2 domain J Virol 80 2006 9226 9235
82. N. Arnaud, S. Dabo, P. Maillard, A. Budkowska, K.I. Kalliampakou, and et al. Hepatitis C virus controls interferon production through PKR activation PloS One 5 2010 e10575
83. U. Garaigorta, and F.V. Chisari Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation Cell Host Microbe 6 2009 513 522
84. H. Oshiumi, M. Ikeda, M. Matsumoto, A. Watanabe, and O. Takeuchi Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction PLoS One 5 2010 e14258
85. A. Dolganiuc, S. Oak, K. Kodys, D.T. Golenbock, R.W. Finberg, E. Kurt-Jones, and G. Szabo Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation Gastroenterology 127 2004 1513 1524
86. U. Duesberg, A. von dem Bussche, C. Kirschning, and et al. Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)-core protein is mediated by toll like receptors (TLRs) 2 and 4 Immunol Lett 84 2002 89 95
87. C. Erridge Endogenous ligands of TLR2 and TLR4: agonists or assistants J Leuk Biol 87 2010 989 999
88. N. Benzoubir, C. Lejamtel, S. Battaglia, B. Testoni, B. Benassi, and et al. HCV core-mediated activation of latent TGF-β and thrombospondin drives the crosstalk between hepatocytes and stromal environment J Hepatol 59 2013 1160 1168
89. M. Coenen, H.D. Nischalke, B. Kramer, B. Langhans, A. Glassner, and et al. Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2 Lab Invest 91 2011 1375 1382
90. S. Ueha, F.H.W. Shand, and K. Matsushima Cellular and molecular mechanisms of inflammation-associated organ fibrosis Front Immunol 3 2012 71
91. V. Appay, R. Dunbar, M. Callan, P. Kienerman, and G.M.A. Gillespie Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections Nat Med 8 2002 379 785
92. H. Wiedemeyer, X.S. He, M. Nascimbeni, A.R. Davis, H.B. Greenberg, and et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection J Immunol 169 2002 3447 3458
93. Z.Q. Yao, A. Eisen-Vandervelde, S.N. Waggoner, E.M. Cale, and Y.S. Hahn Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt J Virol 78 2004 6409 6419
94. Lukens JR1, M.W. Cruise, M.G. Lassen, and Y.S. Hahn Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell response in a hepatitis C virus Core murine model J Immunol 180 2008 4875 4884
95. A.D. Frazier, C.L. Zhang, L. Ni, MaCJ, Y. Zhang, and et al. Programmed Death-1 affects suppressor of cytokine signaling-1 expression in T cells during Hepatitis C infection Viral Immunol 23 2010 487 495
96. E. Romano, and P. Romero The therapeutic promise of PD-1/PD-L1 immune checkpoint in cancer: unleasing the CD8+ T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors J Immunol Cancer 3 2015 15
97. S. Elmore Apoptosis: a review of programmed cell death Toxicol Pathol 35 2007 495 516
98. C.A. Benedict, P.S. Norris, and C.F. Ware To kill or be killed: viral evasion of apoptosis Nat Immunol 3 2003 1013 1018
99. S. Jahan, U.A. Ashfaq, S. Khaliq, B. Samreen, and N. Afzai Dual behavior of HCV Core in regulating apotosis is important in progression of HCC Infect Genet Evol 12 2012 236 239
100. Zekri AR1, A.A. Bahnassy, M.M. Hafez, Z.K. Hassan, M. Kamel, S.A. Loutfy, and et al. Characterization of chronic HCV infection-induced apoptosis Comp Hepatol 10 2011 4
101. M. Saeed, M. Shiina, T. Date, D. Akazawa, N. Watanabe, and et al. In vivo adaptation of hepatitis C virus for efficient virus production and evasion of apoptosis Hepatology 54 2011 425 433
102. M.E. Guicciardi, and G.J. Gores Apoptosis: a mechanism of acute and chronic liver injury Gut 54 2010 1024 1033
103. A.H. Chou, H.F. Tsai, Y.Y. Wu, C.Y. Hu, L.H. Hwang, and et al. Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway J Immunol 174 2005 2160 2166
104. H. Marusawa, M. Hijikata, T. Chiba, and K. Shimotohno Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-κB activation J Virol 73 1999 4713 4721
105. M. Otsuka, N. Kato, K. Lan, H. Yoshida, J. Kato, and et al. Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability J Biol Chem 275 2000 34122 34130
106. R.B. Ray, K. Meyer, R. Steele, A. Shrivastava, B.B. Aggarwal, and et al. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein J Biol Chem 273 1998 2256 2259
107. J. Park, W. Kang, S.W. Ryu, W.I. Kim, D.Y. Chang, and et al. Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-kB Hepatology 56 2012 832 840
108. S.K. Lee, S.O. Park, C.O. Joe, and Y.S. Kim Interaction of HCV core protein with 14-3-3 epsilon protein releases Bax to activate apoptosis Biochem Biophys Res Commun 352 2007 756 762
109. Y. Cao, T. Hamada, T. Matsui, T. Date, and K. Iwabuchi Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis Biochem Biophys Res Commun 315 2004 788 795
110. S.M. Kang, J.K. Choi, S.J. Kim, J.H. Kim, D.G. Ahn, and et al. Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase Biochem Biophys Res Commun 386 2009 55 59
111. J.P. Moorman, D. Prayther, D. McVay, Y.S. Hahn, and C.S. Hahn The C-terminal region of hepatitis C core protein is required for Fas-ligand independent apoptosis in Jurkat cells by facilitating Fas oligomerization Virology 312 2003 320 329
112. K. Wang, B. Lin, J.J. Brems, and R.L. Gamelli Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway Apoptosis 18 2013 566 577
113. K. Wang Autophagy and apoptosis in liver injury Cell Cycle 14 2015 1631 1642
114. Q.C. Zhang, D. Petrey, J.I. Garzón, and et al. PrePPI: a structure-informed database of protein-protein interactions Nucleic Acids Res 41 2013 D828 D833