SCOPUS 정보 검색 플랫폼

ChemMedChem

Volumn 11, Issue 8, 2016, Pages 822-826

Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors

(7) Yan, Lei a Liang, Jiaqi a Yao, Chengbo a Wu, Peiyao a Zeng, Xianfeng a Cheng, Kui a Yin, Hang a

a TSINGHUA UNIVERSITY (China)

Author keywords

flagellin; immunomodulators; inhibitors; protein protein interactions; toll like receptor 5 (TLR5)

Indexed keywords

4 [[4 BENZYL 5 (PYRIDIN4YL) 4H 1,2,4 TRIAZOL 3 YL]THIO]PYRIDO[3',2':4,5] THIENO[3,2 DEXTRO]PYRIMIDINE; ALKALINE PHOSPHATASE; ANTIINFECTIVE AGENT; ETHER DERIVATIVE; FLAGELLIN; PYRIMIDINE DERIVATIVE; THIOETHER DERIVATIVE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AFFECTING AGENT; TRIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; MOLECULAR LIBRARY; PROTEIN BINDING; SULFIDE; TH1020; TLR5 PROTEIN, HUMAN;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOKINE RELEASE; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; MOLECULAR DOCKING; MOLECULAR PROBE; NONHUMAN; NUCLEOPHILICITY; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; FLAGELLIN; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIMIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TOLL-LIKE RECEPTOR 5; TRIAZOLES;

EID: 84964556341 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201500471 Document Type: Article

Times cited : (31)

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