Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 319-323

  Zhao, Chunlin ^a   Tovar, Christian ^b   Yin, Xuefeng ^b   Xu, Qui ^b   Todorov, Ivan T ^c   Vassilev, Lyubomir T ^b   Chen, Li ^a  

^a Discovery Chemistry   (United States)

^b Discovery Oncology   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Anti cancer agent; Cdc 7 inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR; MINICHROMOSOME MAINTENANCE PROTEIN 2; PYRIDOTHIENOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA;

EID: 57749119173     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.093     Document Type: Article

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