-
1
-
-
84882693149
-
Circulating microRNAs as novel biomarkers for diabetes mellitus
-
COI: 1:CAS:528:DC%2BC3sXhtlSitr3O, PID: 23629540
-
Guay C, Regazzi R. Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol. 2013;9:513–21. doi:10.1038/nrendo.2013.86.
-
(2013)
Nat Rev Endocrinol
, vol.9
, pp. 513-521
-
-
Guay, C.1
Regazzi, R.2
-
2
-
-
77957664647
-
MicroRNAs as regulators of differentiation and cell fate decisions
-
COI: 1:CAS:528:DC%2BC3cXps12ktrs%3D, PID: 20621048
-
Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010;7:36–41. doi:10.1016/j.stem.2010.06.012.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 36-41
-
-
Ivey, K.N.1
Srivastava, D.2
-
3
-
-
84883488437
-
MicroRNAs and metabolism crosstalk in energy homeostasis
-
COI: 1:CAS:528:DC%2BC3sXhtV2rsL%2FI, PID: 23850315
-
Dumortier O, Hinault C, Van Obberghen E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 2013;18:312–24. doi:10.1016/j.cmet.2013.06.004.
-
(2013)
Cell Metab
, vol.18
, pp. 312-324
-
-
Dumortier, O.1
Hinault, C.2
Van Obberghen, E.3
-
4
-
-
84904643968
-
The emerging role of microRNAs and nutrition in modulating health and disease
-
COI: 1:CAS:528:DC%2BC2cXhslWitbrO, PID: 25033062
-
Ross SA, Davis CD. The emerging role of microRNAs and nutrition in modulating health and disease. Annu Rev Nutr. 2014;34:305–36. doi:10.1146/annurev-nutr-071813-105729.
-
(2014)
Annu Rev Nutr
, vol.34
, pp. 305-336
-
-
Ross, S.A.1
Davis, C.D.2
-
5
-
-
84891618594
-
The intestinal microbiota interferes with the microRNA response upon oral Listeria infection
-
PID: 24327339
-
Archambaud C et al. The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio. 2013;4:e00707–00713. doi:10.1128/mBio.00707-13.
-
(2013)
mBio
, vol.4
, pp. e00707-e00713
-
-
Archambaud, C.1
-
6
-
-
84929466417
-
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review
-
PID: 25616258
-
Vrijens K, Bollati V, Nawrot TS. MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect. 2015;123:399–411. doi:10.1289/ehp.1408459.
-
(2015)
Environ Health Perspect
, vol.123
, pp. 399-411
-
-
Vrijens, K.1
Bollati, V.2
Nawrot, T.S.3
-
7
-
-
84872932538
-
Intercellular transport of microRNAs
-
COI: 1:CAS:528:DC%2BC3sXht1KksLk%3D, PID: 23325475, This review provides a description of how circulating miRNAs may serve as intercellular messengers mediating organ-to-organ communication in health and disease
-
Boon RA, Vickers KC. Intercellular transport of microRNAs. Arterioscler Thromb Vasc Biol. 2013;33:186–92. doi:10.1161/ATVBAHA.112.300139. This review provides a description of how circulating miRNAs may serve as intercellular messengers mediating organ-to-organ communication in health and disease.
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 186-192
-
-
Boon, R.A.1
Vickers, K.C.2
-
8
-
-
84903717510
-
Development of microRNA therapeutics is coming of age
-
PID: 24935956
-
van Rooij E, Kauppinen S. Development of microRNA therapeutics is coming of age. EMBO Mol Med. 2014;6:851–64. doi:10.15252/emmm.201100899.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 851-864
-
-
van Rooij, E.1
Kauppinen, S.2
-
9
-
-
80052099673
-
MicroRNAs in beta-cell biology, insulin resistance, diabetes and its complications
-
COI: 1:CAS:528:DC%2BC3MXptVChtLg%3D, PID: 21709277
-
Fernandez-Valverde SL, Taft RJ, Mattick JS. MicroRNAs in beta-cell biology, insulin resistance, diabetes and its complications. Diabetes. 2011;60:1825–31. doi:10.2337/db11-0171.
-
(2011)
Diabetes
, vol.60
, pp. 1825-1831
-
-
Fernandez-Valverde, S.L.1
Taft, R.J.2
Mattick, J.S.3
-
10
-
-
84858782897
-
Inhibition of microRNA function by antimiR oligonucleotides
-
COI: 1:CAS:528:DC%2BC38Xlt1Cit7w%3D, PID: 22230293
-
Stenvang J, Petri A, Lindow M, Obad S, Kauppinen S. Inhibition of microRNA function by antimiR oligonucleotides. Silence. 2012;3:1. doi:10.1186/1758-907X-3-1.
-
(2012)
Silence
, vol.3
, pp. 1
-
-
Stenvang, J.1
Petri, A.2
Lindow, M.3
Obad, S.4
Kauppinen, S.5
-
11
-
-
79251581020
-
The art of microRNA research
-
PID: 21252150
-
van Rooij E. The art of microRNA research. Circ Res. 2011;108:219–34. doi:10.1161/CIRCRESAHA.110.227496.
-
(2011)
Circ Res
, vol.108
, pp. 219-234
-
-
van Rooij, E.1
-
12
-
-
84856751210
-
Developing microRNA therapeutics
-
PID: 22302756
-
van Rooij E, Purcell AL, Levin AA. Developing microRNA therapeutics. Circ Res. 2012;110:496–507. doi:10.1161/CIRCRESAHA.111.247916.
-
(2012)
Circ Res
, vol.110
, pp. 496-507
-
-
van Rooij, E.1
Purcell, A.L.2
Levin, A.A.3
-
13
-
-
74249112787
-
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
-
COI: 1:CAS:528:DC%2BC3cXht1egsA%3D%3D, PID: 19965718
-
Lanford RE et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science. 2010;327:198–201. doi:10.1126/science.1178178.
-
(2010)
Science
, vol.327
, pp. 198-201
-
-
Lanford, R.E.1
-
14
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
COI: 1:CAS:528:DC%2BC3sXnt1Wlt7k%3D, PID: 23534542
-
Janssen HL et al. Treatment of HCV infection by targeting microRNA. N Engl J Med. 2013;368:1685–94. doi:10.1056/NEJMoa1209026.
-
(2013)
N Engl J Med
, vol.368
, pp. 1685-1694
-
-
Janssen, H.L.1
-
15
-
-
84855518254
-
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
-
COI: 1:CAS:528:DC%2BC38XnvVGisg%3D%3D, PID: 22160727
-
Frost RJ, Olson EN. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A. 2011;108:21075–80. doi:10.1073/pnas.1118922109.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 21075-21080
-
-
Frost, R.J.1
Olson, E.N.2
-
16
-
-
84867068010
-
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho
-
COI: 1:CAS:528:DC%2BC38XhsFGhsLrI, PID: 22988100
-
Fu T et al. Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho. Proc Natl Acad Sci U S A. 2012;109:16137–42. doi:10.1073/pnas.1205951109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 16137-16142
-
-
Fu, T.1
-
17
-
-
84888131014
-
Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT
-
COI: 1:CAS:528:DC%2BC3sXhvVWgsLbL, PID: 23834033
-
Choi SE et al. Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell. 2013;12:1062–72. doi:10.1111/acel.12135.
-
(2013)
Aging Cell
, vol.12
, pp. 1062-1072
-
-
Choi, S.E.1
-
18
-
-
79959845414
-
-
Trajkovski M et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature. 2011;474:649–53. This is a seminal study on the role of miR-103/107 in regulating insulin sensitivity in the liver and adipose in murine models of diabetes. These findings have led to the selection of miR-103/107 as a candidate for clinical trials ()
-
Trajkovski M et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature. 2011;474:649–53. doi:10.1038/nature10112. This is a seminal study on the role of miR-103/107 in regulating insulin sensitivity in the liver and adipose in murine models of diabetes. These findings have led to the selection of miR-103/107 as a candidate for clinical trials (http://ir.regulusrx.com/releasedetail.cfm?ReleaseID=905305).
-
-
-
-
19
-
-
84874715061
-
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
-
COI: 1:CAS:528:DC%2BC3sXitFaqtLY%3D, PID: 23389544
-
Kornfeld JW et al. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature. 2013;494:111–5. doi:10.1038/nature11793.
-
(2013)
Nature
, vol.494
, pp. 111-115
-
-
Kornfeld, J.W.1
-
20
-
-
84860340270
-
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
-
COI: 1:CAS:528:DC%2BC38Xmt1Kjs7Y%3D, PID: 22541436
-
Grueter CE et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell. 2012;149:671–83. doi:10.1016/j.cell.2012.03.029.
-
(2012)
Cell
, vol.149
, pp. 671-683
-
-
Grueter, C.E.1
-
21
-
-
84866362817
-
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
-
COI: 1:CAS:528:DC%2BC38Xotlelt74%3D, PID: 22476949
-
Zhou B et al. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. 2012;55:2032–43. doi:10.1007/s00125-012-2539-8.
-
(2012)
Diabetologia
, vol.55
, pp. 2032-2043
-
-
Zhou, B.1
-
22
-
-
84922260813
-
MicroRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis
-
PID: 25510864
-
de Guia RM et al. MicroRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. EMBO J. 2015;34:344–60. doi:10.15252/embj.201490464.
-
(2015)
EMBO J
, vol.34
, pp. 344-360
-
-
de Guia, R.M.1
-
23
-
-
84884941624
-
MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade
-
COI: 1:CAS:528:DC%2BC3sXhsFOgsrjL, PID: 24009212
-
Ahn J, Lee H, Jung CH, Jeon TI, Ha TY. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 2013;5:1602–12. doi:10.1002/emmm.201302647.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 1602-1612
-
-
Ahn, J.1
Lee, H.2
Jung, C.H.3
Jeon, T.I.4
Ha, T.Y.5
-
24
-
-
84904739790
-
Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia
-
COI: 1:CAS:528:DC%2BC2cXht1WmsLzP, PID: 24677249
-
Ng R et al. Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. Hepatology. 2014;60:554–64. doi:10.1002/hep.27153.
-
(2014)
Hepatology
, vol.60
, pp. 554-564
-
-
Ng, R.1
-
25
-
-
84938633652
-
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver
-
COI: 1:CAS:528:DC%2BC2MXhsVKhsrzE, PID: 26246194
-
Kurtz CL et al. Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver. Sci Rep. 2015;5:12911. doi:10.1038/srep12911.
-
(2015)
Sci Rep
, vol.5
, pp. 12911
-
-
Kurtz, C.L.1
-
26
-
-
84865494840
-
miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes
-
COI: 1:CAS:528:DC%2BC38XhtlOjsLvK, PID: 22645244
-
Foley NH, O’Neill LA. miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes. J Leukoc Biol. 2012;92:521–7. doi:10.1189/jlb.0312160.
-
(2012)
J Leukoc Biol
, vol.92
, pp. 521-527
-
-
Foley, N.H.1
O’Neill, L.A.2
-
27
-
-
84942811692
-
Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system
-
COI: 1:CAS:528:DC%2BC2MXhsVGis7vI, PID: 26387852
-
Daimiel-Ruiz L et al. Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system. Mol Nutr Food Res. 2015;59:1865–78. doi:10.1002/mnfr.201570094.
-
(2015)
Mol Nutr Food Res
, vol.59
, pp. 1865-1878
-
-
Daimiel-Ruiz, L.1
-
28
-
-
84908868680
-
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function
-
PID: 25182532
-
Fu T et al. MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Mol Cell Biol. 2014;34:4130–42. doi:10.1128/MCB.00596-14.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 4130-4142
-
-
Fu, T.1
-
29
-
-
79958264458
-
Statin myopathy: a common dilemma not reflected in clinical trials
-
PID: 21632911
-
Fernandez G, Spatz ES, Jablecki C, Phillips PS. Statin myopathy: a common dilemma not reflected in clinical trials. Cleve Clin J Med. 2011;78:393–403. doi:10.3949/ccjm.78a.10073.
-
(2011)
Cleve Clin J Med
, vol.78
, pp. 393-403
-
-
Fernandez, G.1
Spatz, E.S.2
Jablecki, C.3
Phillips, P.S.4
-
30
-
-
84938401608
-
Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia
-
COI: 1:CAS:528:DC%2BC2MXhtlyktLvM, PID: 26222559
-
Gaudet D et al. Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia. N Engl J Med. 2015;373:438–47. doi:10.1056/NEJMoa1400283.
-
(2015)
N Engl J Med
, vol.373
, pp. 438-447
-
-
Gaudet, D.1
-
31
-
-
84962171657
-
The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity
-
COI: 1:CAS:528:DC%2BC28XjtF2iu7Y%3D, PID: 26696639
-
Dooley J et al. The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity. Diabetes. 2016;65:53–61. doi:10.2337/db15-0770.
-
(2016)
Diabetes
, vol.65
, pp. 53-61
-
-
Dooley, J.1
-
32
-
-
84906657316
-
MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes
-
PID: 24722248
-
Kurtz CL et al. MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes. 2014;63:3141–8. doi:10.2337/db13-1015.
-
(2014)
Diabetes
, vol.63
, pp. 3141-3148
-
-
Kurtz, C.L.1
-
33
-
-
78751476297
-
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
-
COI: 1:CAS:528:DC%2BC3MXitVeks7c%3D, PID: 20890893
-
Roderburg C et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology. 2011;53:209–18. doi:10.1002/hep.23922.
-
(2011)
Hepatology
, vol.53
, pp. 209-218
-
-
Roderburg, C.1
-
34
-
-
84878561148
-
MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases
-
COI: 1:CAS:528:DC%2BC3sXmtVagu7k%3D, PID: 23542596
-
He Y, Huang C, Lin X, Li J. MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases. Biochimie. 2013;95:1355–9. doi:10.1016/j.biochi.2013.03.010.
-
(2013)
Biochimie
, vol.95
, pp. 1355-1359
-
-
He, Y.1
Huang, C.2
Lin, X.3
Li, J.4
-
35
-
-
80052033649
-
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma
-
COI: 1:CAS:528:DC%2BC3MXpt1aqsLw%3D, PID: 21785411
-
Ma F et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol. 2011;12:861–9. doi:10.1038/ni.2073.
-
(2011)
Nat Immunol
, vol.12
, pp. 861-869
-
-
Ma, F.1
-
36
-
-
84907288399
-
Diverse roles of miR-29 in cancer (review)
-
COI: 1:CAS:528:DC%2BC2cXptlyqs7c%3D, PID: 24573597
-
Jiang H, Zhang G, Wu JH, Jiang CP. Diverse roles of miR-29 in cancer (review). Oncol Rep. 2014;31:1509–16. doi:10.3892/or.2014.3036.
-
(2014)
Oncol Rep
, vol.31
, pp. 1509-1516
-
-
Jiang, H.1
Zhang, G.2
Wu, J.H.3
Jiang, C.P.4
-
37
-
-
84863858371
-
Regulation of cholesterol and fatty acid synthesis
-
Ye J, DeBose-Boyd RA. Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb Perspect Biol. 2011;3. doi:10.1101/cshperspect.a004754.
-
(2011)
Cold Spring Harb Perspect Biol
, pp. 3
-
-
Ye, J.1
DeBose-Boyd, R.A.2
-
38
-
-
84887363120
-
MicroRNA-24/MODY gene regulatory pathway mediates pancreatic beta-cell dysfunction
-
COI: 1:CAS:528:DC%2BC3sXhtl2jtL3E, PID: 23761103
-
Zhu Y et al. MicroRNA-24/MODY gene regulatory pathway mediates pancreatic beta-cell dysfunction. Diabetes. 2013;62:3194–206. doi:10.2337/db13-0151.
-
(2013)
Diabetes
, vol.62
, pp. 3194-3206
-
-
Zhu, Y.1
-
39
-
-
77953780835
-
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
-
COI: 1:CAS:528:DC%2BC3cXnsVWntrY%3D, PID: 20466882
-
Najafi-Shoushtari SH et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010;328:1566–9. doi:10.1126/science.1189123.
-
(2010)
Science
, vol.328
, pp. 1566-1569
-
-
Najafi-Shoushtari, S.H.1
-
40
-
-
77953787211
-
MiR-33 contributes to the regulation of cholesterol homeostasis
-
COI: 1:CAS:528:DC%2BC3cXnsVWntrc%3D, PID: 20466885
-
Rayner KJ et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570–3. doi:10.1126/science.1189862.
-
(2010)
Science
, vol.328
, pp. 1570-1573
-
-
Rayner, K.J.1
-
41
-
-
77955456415
-
miR-33 links SREBP-2 induction to repression of sterol transporters
-
COI: 1:CAS:528:DC%2BC3cXovFyit7c%3D, PID: 20566875
-
Marquart TJ, Allen RM, Ory DS, Baldan A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci U S A. 2010;107:12228–32. doi:10.1073/pnas.1005191107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12228-12232
-
-
Marquart, T.J.1
Allen, R.M.2
Ory, D.S.3
Baldan, A.4
-
42
-
-
85027953543
-
Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice
-
COI: 1:CAS:528:DC%2BC2cXhsVCmur%2FL, PID: 25038053
-
Goedeke L et al. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014;6:1133–41. doi:10.15252/emmm.201404046.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1133-1141
-
-
Goedeke, L.1
-
43
-
-
84874361381
-
Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice
-
COI: 1:CAS:528:DC%2BC3sXisVKqtrY%3D, PID: 23288159
-
Marquart TJ, Wu J, Lusis AJ, Baldan A. Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2013;33:455–8. doi:10.1161/ATVBAHA.112.300639.
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 455-458
-
-
Marquart, T.J.1
Wu, J.2
Lusis, A.J.3
Baldan, A.4
-
44
-
-
80054971110
-
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
-
COI: 1:CAS:528:DC%2BC3MXhtlChtL%2FK, PID: 22012398
-
Rayner KJ et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011;478:404–7. doi:10.1038/nature10486.
-
(2011)
Nature
, vol.478
, pp. 404-407
-
-
Rayner, K.J.1
-
45
-
-
84890387599
-
Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR
-
PID: 24259050
-
Rottiers V et al. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci Transl Med. 2013;5:212ra162. doi:10.1126/scitranslmed.3006840.
-
(2013)
Sci Transl Med
, vol.5
, pp. 212ra162
-
-
Rottiers, V.1
-
46
-
-
84930751975
-
-
Belgardt BF, et al. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes. Nat Med. 2015;21: 619–27.10.1038/nm.3862. This study describes the importance of a specific miRNA family in pancreatic beta cell survival and in the pathophysiology of diabetes. Options for therapeutic silencing of miRNAs in beta cells in vivo remain limited, and represent an important next frontier in research
-
Belgardt BF, et al. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes. Nat Med. 2015;21: 619–27. doi:10.1038/nm.3862. This study describes the importance of a specific miRNA family in pancreatic beta cell survival and in the pathophysiology of diabetes. Options for therapeutic silencing of miRNAs in beta cellsin vivoremain limited, and represent an important next frontier in research.
-
-
-
-
47
-
-
9144270691
-
A pancreatic islet-specific microRNA regulates insulin secretion
-
COI: 1:CAS:528:DC%2BD2cXpsF2gt78%3D, PID: 15538371
-
Poy MN et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432:226–30. doi:10.1038/nature03076.
-
(2004)
Nature
, vol.432
, pp. 226-230
-
-
Poy, M.N.1
-
48
-
-
65249093130
-
miR-375 maintains normal pancreatic alpha- and beta-cell mass
-
COI: 1:CAS:528:DC%2BD1MXkvFagt7c%3D, PID: 19289822
-
Poy MN et al. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A. 2009;106:5813–8. doi:10.1073/pnas.0810550106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5813-5818
-
-
Poy, M.N.1
-
49
-
-
84900797916
-
MicroRNA-7a regulates pancreatic beta cell function
-
COI: 1:CAS:528:DC%2BC2cXpvFahs70%3D, PID: 24789908
-
Latreille M et al. MicroRNA-7a regulates pancreatic beta cell function. J Clin Invest. 2014;124:2722–35. doi:10.1172/JCI73066.
-
(2014)
J Clin Invest
, vol.124
, pp. 2722-2735
-
-
Latreille, M.1
-
50
-
-
84934307590
-
Knocking down disease: a progress report on siRNA therapeutics
-
COI: 1:CAS:528:DC%2BC2MXhtlKnsLnF, PID: 26281785
-
Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015;16:543–52. doi:10.1038/nrg3978.
-
(2015)
Nat Rev Genet
, vol.16
, pp. 543-552
-
-
Wittrup, A.1
Lieberman, J.2
-
51
-
-
84925425958
-
Harnessing RNA interference for therapy: the silent treatment
-
COI: 1:CAS:528:DC%2BC2MXlvVWnu7Y%3D, PID: 25803342, This review highlights the state-of-the-art in anti-sense oligonucleotide (ASO) technology for therapeutics. It includes a discussion of the RNA aptamer based strategy for targeted delivery of ASOs to specific tissues
-
Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015;313:1207–8. doi:10.1001/jama.2015.1241. This review highlights the state-of-the-art in anti-sense oligonucleotide (ASO) technology for therapeutics. It includes a discussion of the RNA aptamer based strategy for targeted delivery of ASOs to specific tissues.
-
(2015)
JAMA
, vol.313
, pp. 1207-1208
-
-
Lieberman, J.1
Sharp, P.A.2
-
52
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
COI: 1:CAS:528:DyaK3cXlt1OltLY%3D, PID: 2200121
-
Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 1990;249:505–10.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
53
-
-
84934307591
-
Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells
-
COI: 1:CAS:528:DC%2BC2MXhs1SlsLzF, PID: 26264278
-
Gilboa-Geffen A et al. Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells. Mol Cancer Ther. 2015;14:2279–91. doi:10.1158/1535-7163.MCT-15-0201-T.
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 2279-2291
-
-
Gilboa-Geffen, A.1
-
54
-
-
84879691173
-
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras
-
COI: 1:CAS:528:DC%2BC3sXmslWqtLs%3D, PID: 23629001
-
Wheeler LA et al. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013;21:1378–89. doi:10.1038/mt.2013.77.
-
(2013)
Mol Ther
, vol.21
, pp. 1378-1389
-
-
Wheeler, L.A.1
|