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Volumn 26, Issue 2, 2016, Pages 67-72

Complement propriety and conspiracy in nanomedicine: Perspective and a hypothesis

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; IMMUNOLOGICAL ADJUVANT; IMMUNOLOGIC FACTOR;

EID: 84964452135     PISSN: 21593337     EISSN: 21593345     Source Type: Journal    
DOI: 10.1089/nat.2015.0587     Document Type: Article
Times cited : (12)

References (66)
  • 1
    • 73849090193 scopus 로고    scopus 로고
    • Complement and its role in innate and adaptive immune responses
    • Dunkelberger JR and W-C Song. (2010). Complement and its role in innate and adaptive immune responses. Cell Res 20: 34-50
    • (2010) Cell Res , vol.20 , pp. 34-50
    • Dunkelberger, J.R.1    Song, W.-C.2
  • 3
    • 84948402126 scopus 로고    scopus 로고
    • Modulatory role of surface coating of superparamagnetic iron oxide nanoworms in complement opsonization and leukocyte uptake
    • Inturi S, G Wang, F Chen, NK Banda, AM Holders, LP Wu, SM Moghimi and D Simberg. (2015). Modulatory role of surface coating of superparamagnetic iron oxide nanoworms in complement opsonization and leukocyte uptake. ACS Nano doi: 10.1021/acsnano.5b05061.
    • (2015) ACS Nano
    • Inturi, S.1    Wang, G.2    Chen, F.3    Banda, N.K.4    Holders, A.M.5    Wu, L.P.6    Moghimi, S.M.7    Simberg, D.8
  • 4
    • 81855198887 scopus 로고    scopus 로고
    • Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective
    • Moghimi SM, AC Hunter and TL Andresen. (2012). Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective. Annu Rev Pharmacol Toxicol 52: 481-503
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 481-503
    • Moghimi, S.M.1    Hunter, A.C.2    Andresen, T.L.3
  • 5
    • 0026493918 scopus 로고
    • DNA binds and activates complement via residues 14-26 of the human C1q A chain
    • Jiang H, B Cooper, FA Robey and H Gewurz. (1992). DNA binds and activates complement via residues 14-26 of the human C1q A chain. J Biol Chem 267: 25597-25601
    • (1992) J Biol Chem , vol.267 , pp. 25597-25601
    • Jiang, H.1    Cooper, B.2    Robey, F.A.3    Gewurz, H.4
  • 6
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank C, K Mechtler, FC Szoka Jr and E Wagner. (1996). Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Human Gene Ther 17: 1437-1446
    • (1996) Human Gene Ther , vol.17 , pp. 1437-1446
    • Plank, C.1    Mechtler, K.2    Szoka, F.C.3    Wagner, E.4
  • 8
    • 33845639957 scopus 로고    scopus 로고
    • Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production
    • Moghimi SM, I Hamad, TL Andresen, K Jørgensen and J Szebeni. (2006). Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production. FASEB J 20: 2591-2593
    • (2006) FASEB J , vol.20 , pp. 2591-2593
    • Moghimi, S.M.1    Hamad, I.2    Andresen, T.L.3    Jørgensen, K.4    Szebeni, J.5
  • 10
    • 78649538085 scopus 로고    scopus 로고
    • Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: Implications for stealth nanoparticle engineering
    • Hamad I, O Al-Hanbali, AC Hunter, KJ Rutt, TL Andresen and SM Moghimi. (2010). Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. ACS Nano 4: 6629-6638
    • (2010) ACS Nano , vol.4 , pp. 6629-6638
    • Hamad, I.1    Al-Hanbali, O.2    Hunter, A.C.3    Rutt, K.J.4    Andresen, T.L.5    Moghimi, S.M.6
  • 12
    • 50549084485 scopus 로고    scopus 로고
    • Randomized phase II trial of a tolllike receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
    • Manegold CD, D Gravenor, D Woytowitz, J Mezger, V Hirsh, G Albert, M Al-Adhami, D Readett, AM Krieg and CG Leichman. (2008). Randomized phase II trial of a tolllike receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J Clin Oncol 26: 3979-3986
    • (2008) J Clin Oncol , vol.26 , pp. 3979-3986
    • Manegold, C.D.1    Gravenor, D.2    Woytowitz, D.3    Mezger, J.4    Hirsh, V.5    Albert, G.6    Al-Adhami, M.7    Readett, D.8    Krieg, A.M.9    Leichman, C.G.10
  • 16
    • 84858762160 scopus 로고    scopus 로고
    • Crosstalk between complement and tolllike receptors
    • Song WC. (2012). Crosstalk between complement and tolllike receptors. Toxicol Pathol 40: 174-182
    • (2012) Toxicol Pathol , vol.40 , pp. 174-182
    • Song, W.C.1
  • 17
    • 0030593030 scopus 로고    scopus 로고
    • C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
    • Dempsey PW, ME Allison, S Akkaraju, CC Goodnow and DT Fearon. (1996). C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271: 348-350
    • (1996) Science , vol.271 , pp. 348-350
    • Dempsey, P.W.1    Allison, M.E.2    Akkaraju, S.3    Goodnow, C.C.4    Fearon, D.T.5
  • 18
    • 84885333791 scopus 로고    scopus 로고
    • Structural insight on the recognition of surface-bound opsonins by the integrin i domain of complement receptor 3
    • Bajic G, L Yatime, RB Sim RB, T Vorup-Jensen and GR Andersen. (2013). Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3. Proc Natl Acad Sci U S A 110: 16426-16431
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 16426-16431
    • Bajic, G.1    Yatime, L.2    Sim, R.B.R.B.3    Vorup-Jensen, T.4    Andersen, G.R.5
  • 19
    • 84867669079 scopus 로고    scopus 로고
    • Genomic perspectives in inter-individual adverse responses following nanomedicine administration: The way forward
    • Moghimi SM, PP Wibroe, S Helvig, ZS Farhangrazi and AC Hunter. (2012). Genomic perspectives in inter-individual adverse responses following nanomedicine administration: the way forward. Adv Drug Deliv Rev 64: 1385-1393
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1385-1393
    • Moghimi, S.M.1    Wibroe, P.P.2    Helvig, S.3    Farhangrazi, Z.S.4    Hunter, A.C.5
  • 22
    • 17644388462 scopus 로고    scopus 로고
    • Role of C5a in inflammatory responses
    • Guo RF and PA Ward. (2005). Role of C5a in inflammatory responses. Annu Rev Immunol 23: 821-852
    • (2005) Annu Rev Immunol , vol.23 , pp. 821-852
    • Guo, R.F.1    Ward, P.A.2
  • 25
    • 84908571917 scopus 로고    scopus 로고
    • Just so stories: The random act of anti-cancer nanomedicine performance
    • Moghimi SM and ZS Farhangrazi. (2014). Just so stories: the random act of anti-cancer nanomedicine performance. Nanomed Nanotechnol Biol Med 10: 1661-1666
    • (2014) Nanomed Nanotechnol Biol Med , vol.10 , pp. 1661-1666
    • Moghimi, S.M.1    Farhangrazi, Z.S.2
  • 26
    • 84906783842 scopus 로고    scopus 로고
    • Cancer nanomedicine and the complement system activation paradigm: Anaphylaxis and tumour growth
    • Moghimi SM. (2014). Cancer nanomedicine and the complement system activation paradigm: anaphylaxis and tumour growth. J Control Release 190: 556-562
    • (2014) J Control Release , vol.190 , pp. 556-562
    • Moghimi, S.M.1
  • 28
    • 80052174164 scopus 로고    scopus 로고
    • Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention
    • Szebeni J, F Muggia, A Gabizon and Y Barenholz. (2011). Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention. Adv Drug Deliv Rev 63: 1020-1030
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 1020-1030
    • Szebeni, J.1    Muggia, F.2    Gabizon, A.3    Barenholz, Y.4
  • 29
    • 84907598811 scopus 로고    scopus 로고
    • Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biological
    • Szebeni J. (2014). Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biological. Mol Immunol 61: 163-173
    • (2014) Mol Immunol , vol.61 , pp. 163-173
    • Szebeni, J.1
  • 30
    • 84869152246 scopus 로고    scopus 로고
    • A porcine model of complementmediated infusion reactions to drug carrier nanosystems and other medicines
    • Szebeni J, P Bedocs, D Csukás, L Rosivall, R Bünger and R Urbanics. (2012). A porcine model of complementmediated infusion reactions to drug carrier nanosystems and other medicines. Adv Drug Deliv Rev 64: 1706-1716
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1706-1716
    • Szebeni, J.1    Bedocs, P.2    Csukás, D.3    Rosivall, L.4    Bünger, R.5    Urbanics, R.6
  • 31
    • 33645739682 scopus 로고    scopus 로고
    • Complement activationrelated cardiac anaphylaxis in pigs: Role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function
    • Szebeni J, L Baranyi, S Sávay, M Bodó, J Milosevits, CR Alving and R Bünger. (2006). Complement activationrelated cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function. Am J Physiol Heart Cir Physiol 290: H1050-H1058
    • (2006) Am J Physiol Heart Cir Physiol , vol.290 , pp. H1050-H1058
    • Szebeni, J.1    Baranyi, L.2    Sávay, S.3    Bodó, M.4    Milosevits, J.5    Alving, C.R.6    Bünger, R.7
  • 32
    • 0032954323 scopus 로고    scopus 로고
    • Hemodynamic changes induced by liposomes and liposomeencapsulated hemoglobin in pigs: A model of pseudoallergic cardiopulmonary reactions to liposomes Role of complement and inhibition by soluble CR1 and anti-C5a antibody
    • Szebeni J, JL Fontana, NM Wassef, PD Morgan, DS Morse, De Dobbins, GL Stahl, R Bünger and CR Alving. (1999). Hemodynamic changes induced by liposomes and liposomeencapsulated hemoglobin in pigs: a model of pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody. Circulation 99: 2302-2309
    • (1999) Circulation , vol.99 , pp. 2302-2309
    • Szebeni, J.1    Fontana, J.L.2    Wassef, N.M.3    Morgan, P.D.4    Morse, D.S.5    Dobbins, D.E.6    Stahl, G.L.7    Bünger, R.8    Alving, C.R.9
  • 33
    • 0141725521 scopus 로고    scopus 로고
    • Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): Possible role in hypersensitivity reactions
    • Chanan-Khan A, J Szebeni, S Savay, L Liebes, NM Rafique, CR Alving and FM Muggia. (2003). Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions. Ann Oncol 14: 1430-1437
    • (2003) Ann Oncol , vol.14 , pp. 1430-1437
    • Chanan-Khan, A.1    Szebeni, J.2    Savay, S.3    Liebes, L.4    Rafique, N.M.5    Alving, C.R.6    Muggia, F.M.7
  • 34
    • 0026685258 scopus 로고
    • Pulmonary intravascular macrophages: A review of immune properties and functions
    • Chitko-McKown CG and F Blecha. (1992). Pulmonary intravascular macrophages: a review of immune properties and functions. Ann Recherches Vétérinaires 23: 201-214
    • (1992) Ann Recherches Vétérinaires , vol.23 , pp. 201-214
    • Chitko-McKown, C.G.1    Blecha, F.2
  • 35
    • 0029987828 scopus 로고    scopus 로고
    • Pulmonary intravascular macrophages
    • Warner AE. (1996). Pulmonary intravascular macrophages. Clin Chest Med 17: 125-135
    • (1996) Clin Chest Med , vol.17 , pp. 125-135
    • Warner, A.E.1
  • 37
    • 0032871011 scopus 로고    scopus 로고
    • Intravascular macrophage depletion attenuates endotoxin lung injury in anesthetized sheep
    • Sone Y, VB Serikov and NC Staub Sr. (1999). Intravascular macrophage depletion attenuates endotoxin lung injury in anesthetized sheep. J Appl Physiol 87: 1354-1359
    • (1999) J Appl Physiol , vol.87 , pp. 1354-1359
    • Sone, Y.1    Serikov, V.B.2    Staub, N.C.3
  • 38
    • 0030712879 scopus 로고    scopus 로고
    • Effect of particles on sheep lung hemodynamics parallels depletion and recovery of intravascular macrophages
    • Stone Y, A Nicolaysen and NC Staub Sr. (1997). Effect of particles on sheep lung hemodynamics parallels depletion and recovery of intravascular macrophages. J Appl Physiol 83: 1499-1507
    • (1997) J Appl Physiol , vol.83 , pp. 1499-1507
    • Stone, Y.1    Nicolaysen, A.2    Staub, N.C.3
  • 40
    • 79251540244 scopus 로고    scopus 로고
    • Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle
    • Schneberger D, D Lewis, S Caldwell and B Singh. (2011). Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle. Int J Exp Pathol 92: 1-7
    • (2011) Int J Exp Pathol , vol.92 , pp. 1-7
    • Schneberger, D.1    Lewis, D.2    Caldwell, S.3    Singh, B.4
  • 41
    • 6344277266 scopus 로고    scopus 로고
    • Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle
    • Wassef A, K Janardhan, JW Pearce and B Singh. (2004). Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle. Histol Histopathol 19: 1201-1208
    • (2004) Histol Histopathol , vol.19 , pp. 1201-1208
    • Wassef, A.1    Janardhan, K.2    Pearce, J.W.3    Singh, B.4
  • 42
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T and S Akira. (2011). Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34: 637-650
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 44
    • 0024602224 scopus 로고
    • Intravascular macrophages in pulmonary capillaries of humans
    • Dehring DJ and BL Wismar. (1989). Intravascular macrophages in pulmonary capillaries of humans. Am Rev Respir Dis 139: 1027-1029
    • (1989) Am Rev Respir Dis , vol.139 , pp. 1027-1029
    • Dehring, D.J.1    Wismar, B.L.2
  • 45
    • 0015807022 scopus 로고
    • An evaluation of lung uptake of colloid during liver imaging
    • Keyes JW Jr, GA Wilson and JD Quinonest. (1973). An evaluation of lung uptake of colloid during liver imaging. J Nucl Med 14: 687-691
    • (1973) J Nucl Med , vol.14 , pp. 687-691
    • Keyes, J.W.1    Wilson, G.A.2    Quinonest, J.D.3
  • 46
    • 0016670432 scopus 로고
    • Liver scan showing intense lung uptake in neoplasia and infection
    • Imarisio JJ. (1975). Liver scan showing intense lung uptake in neoplasia and infection. J Nucl Med 16: 188-190
    • (1975) J Nucl Med , vol.16 , pp. 188-190
    • Imarisio, J.J.1
  • 47
    • 0022646417 scopus 로고
    • Clinical significance of lung uptake in liver scanning
    • Lantto T, M Luostarinen and M Vorne. (1986). Clinical significance of lung uptake in liver scanning. Nuklearmedizin 25: 15-18
    • (1986) Nuklearmedizin , vol.25 , pp. 15-18
    • Lantto, T.1    Luostarinen, M.2    Vorne, M.3
  • 48
    • 0034820459 scopus 로고    scopus 로고
    • Scintigraphic in vivo assessment of the development of pulmonary intravascular macrophages in liver disease
    • Mit-Noirault E, L Faure, Y Guichard, J Monthrau and A Le Pape. (2001). Scintigraphic in vivo assessment of the development of pulmonary intravascular macrophages in liver disease. Chest 120: 941-947
    • (2001) Chest , vol.120 , pp. 941-947
    • Mit-Noirault, E.1    Faure, L.2    Guichard, Y.3    Monthrau, J.4    Le Pape, A.5
  • 49
    • 3042773830 scopus 로고    scopus 로고
    • Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
    • Smith JS, J Tian, JN Lozier and AP Byrnes. (2004). Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats. Mol Ther 9: 932-941
    • (2004) Mol Ther , vol.9 , pp. 932-941
    • Smith, J.S.1    Tian, J.2    Lozier, J.N.3    Byrnes, A.P.4
  • 50
    • 1542359538 scopus 로고    scopus 로고
    • Unexpected pulmonary uptake of adenoviruses in animals with chronic liver disease
    • Smith JS, J Tian, J Muller and AP Byrnes. (2004). Unexpected pulmonary uptake of adenoviruses in animals with chronic liver disease. Gene Ther 11: 431-438
    • (2004) Gene Ther , vol.11 , pp. 431-438
    • Smith, J.S.1    Tian, J.2    Muller, J.3    Byrnes, A.P.4
  • 51
    • 58149476477 scopus 로고    scopus 로고
    • Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model
    • Gill SS, SS Suri, KS Janardhan, S Caldwell, T Duke and B Singh. (2008). Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model. Respir Res 9: 69
    • (2008) Respir Res , vol.9 , pp. 69
    • Gill, S.S.1    Suri, S.S.2    Janardhan, K.S.3    Caldwell, S.4    Duke, T.5    Singh, B.6
  • 54
    • 0141927263 scopus 로고    scopus 로고
    • Stealth liposomes and long-circulating nanoparticles: Critical issues in pharmacokinetics, opsonization and protein-binding properties
    • Moghimi SM and J Szebeni. (2003). Stealth liposomes and long-circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res 42: 463-478
    • (2003) Prog Lipid Res , vol.42 , pp. 463-478
    • Moghimi, S.M.1    Szebeni, J.2
  • 55
    • 0035877049 scopus 로고    scopus 로고
    • Recognition and clearance of methoxypoly (ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity Implications in experimental and clinical oncology
    • Laverman P, MG Carstens, G Storm and SM Moghimi. (2001). Recognition and clearance of methoxypoly (ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity. Implications in experimental and clinical oncology. Biochim Biophys Acta 1526: 227-229
    • (2001) Biochim Biophys Acta , vol.1526 , pp. 227-229
    • Laverman, P.1    Carstens, M.G.2    Storm, G.3    Moghimi, S.M.4
  • 56
    • 0030712178 scopus 로고    scopus 로고
    • A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats
    • Moghimi SM and T Gray. (1997). A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats. Clin Sci 93: 371-379
    • (1997) Clin Sci , vol.93 , pp. 371-379
    • Moghimi, S.M.1    Gray, T.2
  • 57
    • 0030012929 scopus 로고    scopus 로고
    • Poloxamer-188 revisited a potentially valuable immune modulator?
    • Moghimi SM and JC Murray. (1996). Poloxamer-188 revisited: a potentially valuable immune modulator?. J Natl Cancer Inst 88: 766-768
    • (1996) J Natl Cancer Inst , vol.88 , pp. 766-768
    • Moghimi, S.M.1    Murray, J.C.2
  • 58
    • 0027763483 scopus 로고
    • Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosanstimulated rats
    • Moghimi SM, H Hedeman, NM Christy, L Illum and SS Davis. (1993). Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosanstimulated rats. J Leukoc Biol 54: 513-517
    • (1993) J Leukoc Biol , vol.54 , pp. 513-517
    • Moghimi, S.M.1    Hedeman, H.2    Christy, N.M.3    Illum, L.4    Davis, S.S.5
  • 59
  • 60
    • 81855218204 scopus 로고    scopus 로고
    • Reshaping the future of nanopharmaceuticals: Ad iudicium
    • Moghimi SM, D Peer and R Langer. (2011). Reshaping the future of nanopharmaceuticals: ad iudicium. ACS Nano 5: 8454-8458
    • (2011) ACS Nano , vol.5 , pp. 8454-8458
    • Moghimi, S.M.1    Peer, D.2    Langer, R.3
  • 61
  • 62
    • 84896504632 scopus 로고    scopus 로고
    • Shaping cancer nanomedicine: The effect of particle shape on the in vivo journey of nanoparticles
    • Toy R, PM Peiris, KB Ghaghada and E Karathanasis. (2013). Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles. Nanomedicine (Lond) 9: 121-133
    • (2013) Nanomedicine (Lond) , vol.9 , pp. 121-133
    • Toy, R.1    Peiris, P.M.2    Ghaghada, K.B.3    Karathanasis, E.4
  • 63
    • 77957567053 scopus 로고    scopus 로고
    • Therapeutic complement inhibition: New developments
    • Elmen W, W Li and M Kirschfink. (2010). Therapeutic complement inhibition: new developments. Semin Thromb Hemost 36: 660-668
    • (2010) Semin Thromb Hemost , vol.36 , pp. 660-668
    • Elmen, W.1    Li, W.2    Kirschfink, M.3
  • 64
    • 84934440020 scopus 로고    scopus 로고
    • Progress and trends in complement therapeutics
    • Ricklin D and JD Lambris. (2013). Progress and trends in complement therapeutics. Adv Exp Med Biol 735: 1-22
    • (2013) Adv Exp Med Biol , vol.735 , pp. 1-22
    • Ricklin, D.1    Lambris, J.D.2
  • 65
    • 84928780593 scopus 로고    scopus 로고
    • Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
    • Yatime L, C Maasch, K Hoehlig, S Klussmann, GR Andersen and A Vater. (2015). Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer. Nat Commun 6: 6481
    • (2015) Nat Commun , vol.6 , pp. 6481
    • Yatime, L.1    Maasch, C.2    Hoehlig, K.3    Klussmann, S.4    Andersen, G.R.5    Vater, A.6


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