Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

Nature Communications

Volumn 6, Issue , 2015, Pages

  Yatime, Laure ^a   Maasch, Christian ^b   Hoehlig, Kai ^b   Klussmann, Sven ^b   Andersen, Gregers R ^a   Vater, Axel ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b NOXXON PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; CALCIUM ION; COMPLEMENT COMPONENT C5A; DEOXYRIBONUCLEOTIDE; DIVALENT CATION; DNA; GUANINE QUADRUPLEX; MONOVALENT CATION; NOX D20; RIBONUCLEOTIDE; RNA; SPIEGELMER; UNCLASSIFIED DRUG; ANAPHYLATOXIN; C5AR1 PROTEIN, HUMAN; CALCIUM; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT COMPONENT C5A [DEARGININE]; NOX-D20; RECOMBINANT PROTEIN;

DNA; ENZYME ACTIVITY; PHYSIOLOGICAL RESPONSE; RNA; RODENT; TOXIN;

ARTICLE; BINDING AFFINITY; COMPLEMENT INHIBITION; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; DRUG BINDING; DRUG SPECIFICITY; DRUG TARGETING; INTERACTIONS WITH DNA; INTERACTIONS WITH RNA; MOLECULAR RECOGNITION; MOLECULAR STABILITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL LINE; CELL MIGRATION ASSAY; CHEMISTRY; CONFORMATION; ESCHERICHIA COLI; HUMAN; MACACA; METABOLISM; MOUSE; RAT; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE; X RAY CRYSTALLOGRAPHY;

RATTUS;

ANAPHYLATOXINS; ANIMALS; APTAMERS, NUCLEOTIDE; CALCIUM; CELL LINE; CELL MIGRATION ASSAYS; COMPLEMENT C5A; COMPLEMENT C5A, DES-ARGININE; CRYSTALLOGRAPHY, X-RAY; DNA; ESCHERICHIA COLI; HUMANS; MACACA; MICE; NUCLEIC ACID CONFORMATION; RATS; RECEPTOR, ANAPHYLATOXIN C5A; RECOMBINANT PROTEINS; RNA; SELEX APTAMER TECHNIQUE;

EID: 84928780593     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7481     Document Type: Article

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