Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease

Gene Therapy

Volumn 11, Issue 5, 2004, Pages 431-438

  Smith, J S ^a   Tian, J ^a   Muller, J ^a   Byrnes, A P ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Adenovirus; Biodistribution; Cirrhosis; Pulmonary intravascular macrophage; Reticuloendothelial system

Indexed keywords

ADENOVIRUS VECTOR; LUCIFERASE; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLUORESCENCE ANALYSIS; IMMUNOCYTOCHEMISTRY; KUPFFER CELL; LIVER CIRRHOSIS; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION; VIRAL GENE DELIVERY SYSTEM; VIRION;

ADENOVIRIDAE; ANIMALS; CHRONIC DISEASE; GENETIC VECTORS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LUNG; MACROPHAGES, ALVEOLAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION;

ADENOVIRIDAE; ANIMALIA;

EID: 1542359538     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302149     Document Type: Article

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