Target identification of covalently binding drugs by activity-based protein profiling (ABPP)

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 15, 2016, Pages 3291-3303

  Pichler, Christian M ^a   Krysiak, Joanna ^b   Breinbauer, Rolf ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Activity based protein profiling; Biologically active molecules; Covalent binding drugs; Drug targets; Target identification

Indexed keywords

ACETYLSALICYLIC ACID; ACIVICIN; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMPICILLIN; ANDROGRAPHOLIDE; ANTINEOPLASTIC AGENT; BALICATIB; BETA LACTAM; BORTEZOMIB; BRUTON TYROSINE KINASE; CARFILZOMIB; CATHEPSIN K; CEPHALOSPORIN; COVALENTLY BINDING DRUG; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; DRUG; DUOCARMYCIN; FORMESTANE; IBRUTINIB; MONOAMINE OXIDASE INHIBITOR; N (3 PYRIDAZINYL) 4 [3 (5 TRIFLUOROMETHYL 2 PYRIDINYLOXY)BENZYLIDENE] 1 PIPERIDINECARBOXAMIDE; OMEPRAZOLE; PARGYLINE; PROTEOME; SELEGILINE; TETRAHYDROLIPSTATIN; TRIPTOLIDE; UNCLASSIFIED DRUG; WITHAFERIN A; PROTEIN; PROTEIN BINDING;

ACTIVITY BASED PROTEIN PROFILING; ARTICLE; CHEMICAL ANALYSIS; COMPLEX FORMATION; COVALENT BOND; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; FATTY ACID METABOLISM; FLUORESCENCE IMAGING; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; TARGET IDENTIFICATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM; MOLECULARLY TARGETED THERAPY; PROCEDURES;

ANIMALS; DRUG DISCOVERY; HUMANS; MOLECULAR TARGETED THERAPY; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEINS;

EID: 84964403959     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.03.050     Document Type: Article

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