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Chemistry - A European Journal

Volumn 17, Issue 6, 2011, Pages 1922-1929

Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT

(5) Tietze, Lutz F a Schmuck, Kianga a Schuster, Heiko J a Müller, Michael a Schuberth, Ingrid a

a UNIVERSITY OF GÖTTINGEN (Germany)

Author keywords

antitumor agents; cytotoxicity; duocarmycin; glycosides; prodrugs

Indexed keywords

ANTI-TUMOR AGENTS; ANTIBODY-DIRECTED ENZYME PRODRUG THERAPIES; ANTICANCER DRUG; BEST VALUE; BIOLOGICAL EVALUATION; DUOCARMYCIN; GLYCOHYDROLASE; HUMAN SERUM; MONO-THERAPY; NATURAL ANTIBIOTICS; PRODRUGS; SIDE EFFECT;

CHEMOTHERAPY; DRUG INTERACTIONS;

SUGARS;

ANTIBODY; BETA GLUCURONIDASE; DNA; DUOCARMYCIN SA; INDOLE DERIVATIVE; PRODRUG; PYRROLE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; HUMAN; IC 50; METABOLISM; SYNTHESIS;

ANTIBODIES; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GLUCURONIDASE; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PRODRUGS; PYRROLES;

EID: 79551469662 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201002798 Document Type: Article

Times cited : (27)

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