Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism

Nature Immunology

Volumn 17, Issue 6, 2016, Pages 677-686

  Ouimet, Mireille ^a   Koster, Stefan ^b   Sakowski, Erik ^b   Ramkhelawon, Bhama ^a   Van Solingen, Coen ^a   Oldebeken, Scott ^a   Karunakaran, Denuja ^c   Portal Celhay, Cynthia ^b   Sheedy, Frederick J ^d   Ray, Tathagat Dutta ^a   Cecchini, Katharine ^e   Zamore, Philip D ^e   Rayner, Katey J ^c   Marcel, Yves L ^c   Philips, Jennifer A ^b,f   Moore, Kathryn J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; AUTOPHAGY PROTEIN 5; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CITRININ; CORD FACTOR; FAT DROPLET; LIPOARABINOMANNAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MESSENGER RNA; MICRORNA; MICRORNA 33; OLIGOMYCIN; RED FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR TFEB; UNCLASSIFIED DRUG; MIRN33 MICRORNA, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BACTERIAL CELL WALL; BACTERIAL CLEARANCE; BACTERIAL SURVIVAL; BACTERIAL VIABILITY; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE LOCUS; HEK293 CELL LINE; HEMATOPOIETIC CELL; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; LIPID METABOLISM; LIPOLYSIS; LUNG ALVEOLUS MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR REPROGRAMMING; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPHAGY; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNE EVASION; KNOCKOUT MOUSE; LYSOSOME; MACROPHAGE; MALE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUBERCULOSIS;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; LIPID METABOLISM; LYSOSOMES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; MYCOBACTERIUM TUBERCULOSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUBERCULOSIS;

EID: 84964374656     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3434     Document Type: Article

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