New concept of the biosynthesis of 4-alkyl-L-proline precursors of lincomycin, hormaomycin, and pyrrolobenzodiazepines: Could a γ-glutamyltransferase cleave the C-C bond?

Frontiers in Microbiology

Volumn 7, Issue MAR, 2016, Pages

  Jiraskova, Petra ^a   Gazak, Radek ^a   Kamenik, Zdenek ^a   Steiningerova, Lucie ^a   Najmanova, Lucie ^a   Kadlcik, Stanislav ^a   Novotna, Jitka ^a,b   Kuzma, Marek ^a   Janata, Jiri ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

4 propyl L proline; Antibiotics; Anticancer drug; Hormaomycin; Lincomycin; Natural product biosynthesis; Pyrrolobenzodiazepine; Secondary metabolism

Indexed keywords

4 ALKYL L PROLINE DERIVATIVE; ANTINEOPLASTIC AGENT; GAMMA GLUTAMYLTRANSFERASE; HORMAOMYCIN; HORMONE; LINCOMYCIN; PROLINE DERIVATIVE; PYRROLO (1 4) BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; C C BOND CLEAVING ENZYMATIC ACTIVITY; CARBON CARBON BOND; CHEMICAL BOND; ENZYME ACTIVITY; GENE INACTIVATION; ISOMER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRECURSOR; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS;

EID: 84964330585     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.00276     Document Type: Article

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