Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A

Nature

Volumn 518, Issue 7537, 2015, Pages 115-119

  Zhao, Qunfei ^a   Wang, Min ^a   Xu, Dongxiao ^a   Zhang, Qinglin ^b   Liu, Wen ^a,b  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b Huzhou Center of Bio Synthetic Innovation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; LINCOMYCIN; MYCOTHIOL; SULFUR; THIOL; THIONEINE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CYSTEINE; GLYCOPEPTIDE; INOSITOL; LINCOSAMIDE;

ANTIBIOTICS; BACTERIUM; BIOCHEMISTRY; BIOTRANSFORMATION; ENZYME ACTIVITY; EUKARYOTE; METABOLISM; PEPTIDE; REACTION KINETICS; THIOL;

ADENYLATION; ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; BIOSYNTHESIS; BIOTRANSFORMATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; GLYCOSYLATION; GRAM POSITIVE INFECTION; IN VITRO STUDY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; STREPTOMYCES;

ACTINOBACTERIA; ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; EUKARYOTA; NEGIBACTERIA; POSIBACTERIA;

ANTI-BACTERIAL AGENTS; BIOLOGICAL PRODUCTS; BIOSYNTHETIC PATHWAYS; BIOTRANSFORMATION; CYSTEINE; ERGOTHIONEINE; GLYCOPEPTIDES; GLYCOSYLATION; INOSITOL; LINCOMYCIN; LINCOSAMIDES; MOLECULAR SEQUENCE DATA; STREPTOMYCES;

EID: 84923087541     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14137     Document Type: Article

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