In vitro characterization of LmbK and LmbO: Identification of GDP-d-erythro-α-d-gluco-octose as a key intermediate in lincomycin a biosynthesis

Journal of the American Chemical Society

Volumn 136, Issue 3, 2014, Pages 906-909

  Lin, Chia I ^a   Sasaki, Eita ^a   Zhong, Aoshu ^a   Liu, Hung Wen ^a  

^a The University of Texas at Austin   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC PATHWAY; D-FRUCTOSE; D-RIBOSE; ENZYMATIC TRANSFORMATION; IN-VITRO; REACTION CATALYZED;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS;

LINEARIZATION;

BACTERIAL PROTEIN; GUANOSINE DERIVATIVE; GUANOSINE DIPHOSPHATE DEXTRO ERYTHRO ALPHA DEXTRO GLUCO OCTOSE; LINCOMYCIN; LINCOSAMIDE DERIVATIVE; LMBK PROTEIN; LMBO PROTEIN; METHYLTHIOLINCOSAMIDE; OCTOSE 1 PHOSPHATE; OCTOSE 1 PHOSPHATE GUANYLYLTRANSFERASE; OCTOSE 1,8 BISPHOSPHATE; PHOSPHATE; SULFUR; TRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CATALYST; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS;

GUANOSINE DIPHOSPHATE SUGARS; LINCOMYCIN; MONOSACCHARIDES; NUCLEOTIDYLTRANSFERASES; PHOSPHORIC MONOESTER HYDROLASES; STREPTOMYCES;

EID: 84893020223     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja412194w     Document Type: Article

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