Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Novotna, Jitka ^a,b,c   Olsovska, Jana ^a,g   Novak, Petr ^a   Mojzes, Peter ^d   Chaloupkova, Radka ^e   Kamenik, Zdenek ^a   Spizek, Jaroslav ^a   Kutejova, Eva ^a,f   Mareckova, Marketa ^c   Tichy, Pavel ^a   Damborsky, Jiri ^e   Janata, Jiri ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b CENTRAL EUROPEAN INSTITUTE OF TECHNOLOGY   (Czech Republic)

^c CROP RESEARCH INSTITUTE   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e MASARYK UNIVERSITY   (Czech Republic)

^f INSTITUTE OF CHEMISTRY   (Slovakia)

^g Research Institute of Brewing and Malting   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAMYCIN; CYTOCHROME P450; DOPA; HEMOPROTEIN; IRON; LINCOMYCIN; TETRAHYDROBIOPTERIN; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE; GENE CLUSTER; LMBB2 GENE; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; RAMAN SPECTROMETRY; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DIHYDROXYPHENYLALANINE; ESCHERICHIA COLI; GENE EXPRESSION; HEME; HEMEPROTEINS; HYDROXYLATION; IRON; LINCOMYCIN; MULTIGENE FAMILY; RECOMBINANT PROTEINS; STREPTOMYCES; TYROSINE; TYROSINE 3-MONOOXYGENASE;

EID: 84891858483     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079974     Document Type: Article

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