Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis

Journal of Applied Microbiology

Volumn 119, Issue 4, 2015, Pages 1064-1074

  Pang, A P ^a,b,c   Du, L ^a,b,c,d   Lin, C Y ^a,b,c   Qiao, J ^a,b,c   Zhao, G R ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b TIANJIN UNIVERSITY   (China)

^c Collaborative Innovation Center of Chemical Science and Engineering   (China)

^d QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

Author keywords

lmbW; Streptomyces lincolnensis; Lincomycin; Metabolic engineering; Methyltransferase; Synthetic biology

Indexed keywords

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; C (PROGRAMMING LANGUAGE); ENCODING (SYMBOLS); GENE EXPRESSION;

DELETION MUTANTS; IN-SILICO; INDUSTRIAL STRAIN; LINCOMYCIN; LMBW; METHYLTRANSFERASES; OVEREXPRESSIONS; SILICO ANALYSIS; STREPTOMYCES LINCOLNENSIS; SYNTHETIC BIOLOGY;

METABOLIC ENGINEERING;

LINCOMYCIN; LINCOMYCIN B; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; LINCOMYCIN-B; LINCOSAMIDE; METHIONINE ADENOSYLTRANSFERASE;

ANTIBIOTICS; BACTERIUM; BIOENGINEERING; ENZYME ACTIVITY; FERMENTATION; GENE EXPRESSION; INDUSTRIAL PRODUCTION; SEPARATION;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOENGINEERING; CONTROLLED STUDY; DELETION MUTANT; GENE FUNCTION; GENE OVEREXPRESSION; LMBW GENE; METK GENE; NONHUMAN; STREPTOMYCES; STREPTOMYCES LINCOLNENSIS; BIOSYNTHESIS; FERMENTATION; GENETICS; METABOLISM; MOLECULAR GENETICS;

STREPTOMYCES LINCOLNENSIS;

BACTERIAL PROTEINS; FERMENTATION; LINCOMYCIN; LINCOSAMIDES; METHIONINE ADENOSYLTRANSFERASE; MOLECULAR SEQUENCE DATA; STREPTOMYCES;

EID: 84942163364     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/jam.12919     Document Type: Article

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