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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 775-780

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

(16) Wu, Bin a Wang, Hui Ling a Cee, Victor J a Lanman, Brian A a Nixey, Thomas a Pettus, Liping a Reed, Anthony B a Wurz, Ryan P a Guerrero, Nadia a Sastri, Christine a Winston, Jeff a Lipford, J Russell a Lee, Matthew R a Mohr, Christopher a Andrews, Kristin L a Tasker, Andrew S a

a AMGEN INC (United States)

Author keywords

1 3 4 Thiadiazol 2 amines; Kinase inhibitors; Lead optimization; PIM kinases

Indexed keywords

5 (1H INDOL 5 YL) 1,3,4 THIADIAZOL 2 AMINE; ISOENZYME; PIM KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION;

EID: 84964219506 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.12.091 Document Type: Article

Times cited : (27)

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