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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4599-4604

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

(18) Dakin, Les A a Block, Michael H a Chen, Huawei a Code, Erin a Dowling, James E a Feng, Xiaomei a Ferguson, Andrew D a Green, Isabelle a Hird, Alexander W a Howard, Tina a Keeton, Erika K a Lamb, Michelle L a Lyne, Paul D a Pollard, Hannah a Read, Jon a Wu, Allan J a Zhang, Tao a Zheng, Xiaolan a

a ASTRAZENECA (United Kingdom)

Author keywords

Cancer; Hit to lead; PIM kinases; Small molecule inhibitor; Thiazolidine 2,4 dione; X ray crystallography

Indexed keywords

BENZYLIDENE 1,3 THIAZOLIDINE 2,4 DIONE DERIVATIVE; BENZYLIDENE DERIVATIVE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZYLIDENE COMPOUNDS; CELL LINE; CELL PROLIFERATION; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 84863447425 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.098 Document Type: Article

Times cited : (96)

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