The design, synthesis, and biological evaluation of PIM kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3732-3738

  Tsuhako, Amy Lew ^a   Brown, David S ^a   Koltun, Elena S ^a   Aay, Naing ^a   Arcalas, Arlyn ^a   Chan, Vicky ^a   Du, Hongwang ^a   Engst, Stefan ^a   Franzini, Maurizio ^a   Galan, Adam ^a   Huang, Ping ^a   Johnston, Stuart ^a   Kane, Brian ^a   Kim, Moon H ^a   Douglas Laird, A ^a   Lin, Rui ^a   Mock, Lillian ^a   Ngan, Iris ^a   Pack, Michael ^a   Stott, Gordon ^a   Stout, Thomas J ^a   Yu, Peiwen ^a   Zaharia, Cristiana ^a   Zhang, Wentao ^a   Zhou, Peiwen ^a   Nuss, John M ^a   Kearney, Patrick C ^a   Xu, Wei ^a   more..

^a EXELIXIS INC   (United States)

Author keywords

Benzofuropyrimidinone; Cdc7 inhibitor; CK2 inhibitor; PIM 1; PIM 2; PIM 3

Indexed keywords

ALKYL BENZOFUROPYRIMIDINONE; ANTINEOPLASTIC AGENT; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FURANS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861190659     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.025     Document Type: Article

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