Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 304-310

  Letribot, Boris ^a,b   Akué Gédu, Rufine ^a,b   Santio, Niina M ^c   El Ghozzi, Malika ^a,b   Avignant, Daniel ^a,b   Cisnetti, Federico ^a,b   Koskinen, Päivi J ^c   Gautier, Arnaud ^a,b   Anizon, Fabrice ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

CuAAC (Copper(I) Catalyzed Azide Alkyne Cycloaddition); Pim kinase inhibition; Pyrrolo 2,3 a carbazole 3 carbaldehyde

Indexed keywords

10 (4 AZIDOBUTYL) 1 (PHENYLSULFONYL) 1,10 DIHYDROPYRROLO(2,3 A)CARBAZOLE; 10 (4 AZIDOBUTYL) 1,10 DIHYDROPYRROLO(2,3 A)CARBAZOLE; 10 (4 AZIDOBUTYL) 1,10 DIHYDROPYRROLO(2,3 A)CARBAZOLE 3 CARBALDEHYDE; 10 (4 BROMOBUTYL) 1 (PHENYLSULFONYL) 1,10 DIHYDROPYRROLO(2,3 A)CARBAZOLE; 10 [4 [4 (HYDROXYMETHYL) 1H 1,2,3 TRIAZOL 1 YL]BUTYL] 1,10 DIHYDROPYRROLO(2,3 A)CARBAZOLE 3 CARBALDEHYDE; 5 (DIMETHYLAMINO) N [[1 [4 [3 FORMYLPYRROLO(2,3 A)CARBAZOL 10 (1H) YL]BUTYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]NAPHTHALENE 1 SULFONAMIDE; ALKYNE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; COPPER; N (2 HYDROXYETHYL) N,N DIMETHYLPROP 2 YN 1 AMINIUM CHLORIDE; N [[1 [4 [3 FORMYLPYRROLO(2,3 A)CARBAZOL 10 (1H) YL]BUTYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 HYDROXY N,N DIMETHYLETHANAMINIUM TRIFLUOROACETATE; NITROGEN; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ATOM; BINDING SITE; CANCER CELL CULTURE; CATALYSIS; CELL MEMBRANE; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYCLOADDITION; CYTOPLASM; DRUG CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILICITY; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY DIFFRACTION;

ALKYNES; AZIDES; CARBAZOLES; CATALYSIS; CELL MEMBRANE; COPPER; CYTOPLASM; HUMANS; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

EID: 84858441553     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.009     Document Type: Article

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