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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6178-6182

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach

(12) Dwyer, Michael P a Keertikar, Kartik a Paruch, Kamil a Alvarez, Carmen a Labroli, Marc a Poker, Cory a Fischmann, Thierry O a Mayer Ezell, Rosemary a Bond, Richard a Wang, Yan a Azevedo, Rita b Guzi, Timothy J a

a MERCK RESEARCH LABORATORIES (United States)

b Molecular Design and Informatics (Netherlands)

Author keywords

Pan Pim kinase; pyrazolo 1,5 a pyrimidine

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; DINACICLIB; FURAN DERIVATIVE; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; OXADIAZOLE DERIVATIVE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SCH 900776; UNCLASSIFIED DRUG;

ARTICLE; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; IC 50; IN VITRO STUDY; OXIDATION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

PAN-PIM KINASE; PYRAZOLO[1,5-A]PYRIMIDINE;

HUMANS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885957223 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.08.110 Document Type: Article

Times cited : (38)

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