Structure guided optimization, in vitro activity, and in vivo activity of pan-PIM kinase inhibitors

ACS Medicinal Chemistry Letters

Volumn 4, Issue 12, 2013, Pages 1193-1197

  Burger, Matthew T ^a   Han, Wooseok ^a   Lan, Jiong ^a   Nishiguchi, Gisele ^a   Bellamacina, Cornelia ^a   Lindval, Mika ^a   Atallah, Gordana ^a   Ding, Yu ^a   Mathur, Michelle ^a   Mcbride, Chris ^a   Beans, Elizabeth L ^a   Muller, Kristine ^a   Tamez, Victoriano ^a   Zhang, Yanchen ^a   Huh, Kay ^a   Feucht, Paul ^a   Zavorotinskaya, Tatiana ^a   Dai, Yumin ^a   Holash, Jocelyn ^a   Castillo, Joseph ^a   Langowski, John ^a   Wang, Yingyun ^a   Chen, Min Y ^a   Garcia, Pablo D ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

pan Pim kinase inhibitors; Pim1 kinase inhibitor; Pim2 kinase inhibitor; Pim3 kinase inhibitor; Proviral insetion site in Moloney murine leukemia virus kinases inhibitors

Indexed keywords

ACICLOVIR; PHOSPHOTRANSFERASE INHIBITOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER MODEL; CELL PROLIFERATION; CELL SURVIVAL; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MOLECULAR WEIGHT; MOLONEY LEUKEMIA ONCOVIRUS; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION;

EID: 84890522007     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400307j     Document Type: Article

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