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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3149-3153

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

(15) Wang, Xiaojing a Magnuson, Steven a Pastor, Rich a Fan, Eric b Hu, Huiyong a Tsui, Vickie a Deng, Wei c Murray, Jeremy a Steffek, Micah d Wallweber, Heidi a Moffat, John a Drummond, Jason a Chan, Grace a Harstad, Eric a Ebens, Allen J a

a GENENTECH INC (United States)

b Campbell Alliance (United States)

c MERCK RESEARCH LABORATORIES (United States)

d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

High throughput screening; Kinase inhibitor; Lead optimization; Pim kinases; Structure based drug design

Indexed keywords

PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZOLO[1,5 A]PYRIMIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CYTOTOXICITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

EID: 84877582049 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.020 Document Type: Article

Times cited : (59)

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