메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Quercetin inhibits fibroblast activation and kidney fibrosis involving the suppression of mammalian target of rapamycin and β-catenin signaling

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; BETA CATENIN; CYTOKINE; FIBRONECTIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; QUERCETIN; SMAD PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84964010115     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23968     Document Type: Article
Times cited : (60)

References (51)
  • 1
    • 82355190219 scopus 로고    scopus 로고
    • And molecular mechanisms of renal fibrosis
    • Liu, Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 7, 684-96 (2011)
    • (2011) Nat Rev Nephrol , vol.7 , pp. 684-696
    • Liu, Y.1    Cellular2
  • 2
    • 84902179695 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms in kidney fibrosis
    • Duffield, J. S. Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest 124, 2299-306 (2014)
    • (2014) J Clin Invest , vol.124 , pp. 2299-2306
    • Duffield, J.S.1
  • 3
    • 84859649198 scopus 로고    scopus 로고
    • Renal interstitial fibrosis: Mechanisms and evaluation
    • Farris, A. B., & Colvin, R. B. Renal interstitial fibrosis: mechanisms and evaluation. Curr Opin Nephrol Hypertens 21, 289-300 (2012)
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 289-300
    • Farris, A.B.1    Colvin, R.B.2
  • 4
    • 84882289111 scopus 로고    scopus 로고
    • Origin and function of myofibroblasts in kidney fibrosis
    • LeBleu, V. S. et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19, 1047-53 (2013)
    • (2013) Nat Med , vol.19 , pp. 1047-1053
    • LeBleu, V.S.1
  • 5
    • 84902180610 scopus 로고    scopus 로고
    • Kidney disease: New technologies translate mechanisms to cure
    • O?Toole, J. F., & Sedor, J. R. Kidney disease: new technologies translate mechanisms to cure. J Clin Invest 124, 2294-8 (2014)
    • (2014) J Clin Invest , vol.124 , pp. 2294-2298
    • O'Toole, J.F.1    Sedor, J.R.2
  • 6
    • 84927175105 scopus 로고    scopus 로고
    • Growth factor and small molecule influence on urological tissue regeneration utilizing cell seeded scaffolds
    • Sharma, A. K., & Cheng, E. Y. Growth factor and small molecule influence on urological tissue regeneration utilizing cell seeded scaffolds. Adv Drug Deliv Rev 82-83, 86-92 (2015)
    • (2015) Adv Drug Deliv Rev , pp. 82-92
    • Sharma, A.K.1    Cheng, E.Y.2
  • 7
    • 70349506109 scopus 로고    scopus 로고
    • In vitro anti-fibrotic activities of herbal compounds and herbs
    • Hu, Q. et al. In vitro anti-fibrotic activities of herbal compounds and herbs. Nephrol Dial Transplant 24, 3033-41 (2009)
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3033-3041
    • Hu, Q.1
  • 8
    • 0029610477 scopus 로고
    • Review of the biology of Quercetin and related bioflavonoids
    • Formica, J. V., & Regelson, W. Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol 33, 1061-80 (1995)
    • (1995) Food Chem Toxicol , vol.33 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 9
    • 29044437421 scopus 로고    scopus 로고
    • Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats
    • Morales, A. I. et al. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharmacol 210, 128-35 (2006)
    • (2006) Toxicol Appl Pharmacol , vol.210 , pp. 128-135
    • Morales, A.I.1
  • 10
    • 71049128963 scopus 로고    scopus 로고
    • Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function
    • Tang, D. et al. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Am J Respir Cell Mol Biol 41, 651-60 (2009)
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 651-660
    • Tang, D.1
  • 11
    • 40049092280 scopus 로고    scopus 로고
    • Protective effects of a combination of quercetin and Vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats
    • Mostafavi-Pour, Z., Zal, F., Monabati, A., & Vessal, M. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res 38, 385-92 (2008)
    • (2008) Hepatol Res , vol.38 , pp. 385-392
    • Mostafavi-Pour, Z.1    Zal, F.2    Monabati, A.3    Vessal, M.4
  • 12
    • 84894125705 scopus 로고    scopus 로고
    • Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats
    • Taslidere, E., Esrefoglu, M., Elbe, H., Cetin, A., & Ates, B. Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats. Exp Lung Res 40, 59-65 (2014)
    • (2014) Exp Lung Res , vol.40 , pp. 59-65
    • Taslidere, E.1    Esrefoglu, M.2    Elbe, H.3    Cetin, A.4    Ates, B.5
  • 13
    • 84869784553 scopus 로고    scopus 로고
    • Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/ anti-fibrogenic molecules balance
    • Hernandez-Ortega, L. D. et al. Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/ anti-fibrogenic molecules balance. J Gastroenterol Hepatol 27, 1865-72 (2012)
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 1865-1872
    • Hernandez-Ortega, L.D.1
  • 14
    • 79955492201 scopus 로고    scopus 로고
    • Attenuation of transforming growth factor-beta-stimulated collagen production in fibroblasts by quercetininduced heme oxygenase-1
    • Nakamura, T. et al. Attenuation of transforming growth factor-beta-stimulated collagen production in fibroblasts by quercetininduced heme oxygenase-1. Am J Respir Cell Mol Biol 44, 614-20 (2011)
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 614-620
    • Nakamura, T.1
  • 15
    • 84882280634 scopus 로고    scopus 로고
    • Quercetin inhibits radiation-induced skin fibrosis
    • Horton, J. A. et al. Quercetin inhibits radiation-induced skin fibrosis. Radiat Res 180, 205-15 (2013)
    • (2013) Radiat Res , vol.180 , pp. 205-215
    • Horton, J.A.1
  • 16
    • 0345304436 scopus 로고    scopus 로고
    • Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars
    • Phan, T. T. et al. Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars. J Dermatol Sci 33, 192-4 (2003)
    • (2003) J Dermatol Sci , vol.33 , pp. 192-194
    • Phan, T.T.1
  • 17
    • 84929734614 scopus 로고    scopus 로고
    • Effect of pioglitazone, quercetin, and hydroxy citric acid on vascular endothelial growth factor messenger RNA (VEGF mRNA) expression in experimentally induced nonalcoholic steatohepatitis (NASH)
    • Surapaneni, K. M., Vishnu Priya, V., & Mallika, J. Effect of pioglitazone, quercetin, and hydroxy citric acid on vascular endothelial growth factor messenger RNA (VEGF mRNA) expression in experimentally induced nonalcoholic steatohepatitis (NASH). Turk J Med Sci 45, 542-6 (2015)
    • (2015) Turk J Med Sci , vol.45 , pp. 542-546
    • Surapaneni, K.M.1    Vishnu Priya, V.2    Mallika, J.3
  • 18
    • 84899525682 scopus 로고    scopus 로고
    • Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis
    • Chen, J., Xia, Y., Lin, X., Feng, X. H., & Wang, Y. Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis. Lab Invest 94, 545-56 (2014)
    • (2014) Lab Invest , vol.94 , pp. 545-556
    • Chen, J.1    Xia, Y.2    Lin, X.3    Feng, X.H.4    Wang, Y.5
  • 20
    • 84879951583 scopus 로고    scopus 로고
    • Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis
    • Jiang, L. et al. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. J Am Soc Nephrol 24, 1114-26 (2013)
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1114-1126
    • Jiang, L.1
  • 21
    • 74049137551 scopus 로고    scopus 로고
    • Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis
    • Wang, S., Wilkes, M. C., Leof, E. B., & Hirschberg, R. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Am J Physiol Renal Physiol 298, F142-9 (2010)
    • (2010) Am J Physiol Renal Physiol , vol.298 , pp. F142-F149
    • Wang, S.1    Wilkes, M.C.2    Leof, E.B.3    Hirschberg, R.4
  • 22
    • 77957573525 scopus 로고    scopus 로고
    • Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocininduced diabetic nephropathy
    • Li, J. et al. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocininduced diabetic nephropathy. Diabetes 59, 2612-24 (2010)
    • (2010) Diabetes , vol.59 , pp. 2612-2624
    • Li, J.1
  • 23
    • 33745269545 scopus 로고    scopus 로고
    • Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
    • Wu, M. J. et al. Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis. Kidney Int 69, 2029-36 (2006)
    • (2006) Kidney Int , vol.69 , pp. 2029-2036
    • Wu, M.J.1
  • 24
    • 84940789259 scopus 로고    scopus 로고
    • Rictor/mTORC2 signaling mediates TGFbeta1-induced fibroblast activation and kidney fibrosis
    • Li, J. et al. Rictor/mTORC2 signaling mediates TGFbeta1-induced fibroblast activation and kidney fibrosis. Kidney Int 88, 515-27 (2015)
    • (2015) Kidney Int , vol.88 , pp. 515-527
    • Li, J.1
  • 25
    • 80052335469 scopus 로고    scopus 로고
    • Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis
    • Hao, S. et al. Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 22, 1642-53 (2011)
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1642-1653
    • Hao, S.1
  • 26
    • 80052380331 scopus 로고    scopus 로고
    • Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling
    • Wang, K. et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 7, 966-78 (2011)
    • (2011) Autophagy , vol.7 , pp. 966-978
    • Wang, K.1
  • 27
    • 84867651619 scopus 로고    scopus 로고
    • Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways
    • Pratheeshkumar, P. et al. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. Plos One 7, e47516 (2012)
    • (2012) Plos One , vol.7 , pp. e47516
    • Pratheeshkumar, P.1
  • 28
    • 84882366268 scopus 로고    scopus 로고
    • Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells
    • Kim, H. et al. Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells. Int J Oncol 43, 1319-25 (2013)
    • (2013) Int J Oncol , vol.43 , pp. 1319-1325
    • Kim, H.1
  • 29
    • 12844274417 scopus 로고    scopus 로고
    • Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells
    • Park, C. H. et al. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 328, 227-34 (2005)
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 227-234
    • Park, C.H.1
  • 30
    • 0033758778 scopus 로고    scopus 로고
    • The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction
    • Peres, W. et al. The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J Hepatol 33, 742-50 (2000)
    • (2000) J Hepatol , vol.33 , pp. 742-750
    • Peres, W.1
  • 31
    • 84952036352 scopus 로고    scopus 로고
    • Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis
    • Zhou, D., & Liu, Y. Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis. Nat Rev Nephrol 12, 68-70 (2016)
    • (2016) Nat Rev Nephrol , vol.12 , pp. 68-70
    • Zhou, D.1    Liu, Y.2
  • 32
    • 84928592867 scopus 로고    scopus 로고
    • Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells
    • Kim, G. T., Lee, S. H., & Kim, Y. M. Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells. J Cancer Prev 18, 264-70 (2013)
    • (2013) J Cancer Prev , vol.18 , pp. 264-270
    • Kim, G.T.1    Lee, S.H.2    Kim, Y.M.3
  • 33
    • 84879029662 scopus 로고    scopus 로고
    • Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors
    • Welker, M. E., & Kulik, G. Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors. Bioorg Med Chem 21, 4063-91 (2013)
    • (2013) Bioorg Med Chem , vol.21 , pp. 4063-4091
    • Welker, M.E.1    Kulik, G.2
  • 34
    • 84940163799 scopus 로고    scopus 로고
    • Blockage of Wnt/beta-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro
    • Novo, M. C. et al. Blockage of Wnt/beta-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro. Immunobiology 220, 60-7 (2015)
    • (2015) Immunobiology , vol.220 , pp. 60-67
    • Novo, M.C.1
  • 35
    • 67649946192 scopus 로고    scopus 로고
    • Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway
    • Shan, B. E., Wang, M. X., & Li, R. Q. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest 27, 604-12 (2009)
    • (2009) Cancer Invest , vol.27 , pp. 604-612
    • Shan, B.E.1    Wang, M.X.2    Li, R.Q.3
  • 36
    • 84908545060 scopus 로고    scopus 로고
    • Oxidative stress, and fibrosis in chronic kidney disease
    • Sharma, K. Obesity, oxidative stress, and fibrosis in chronic kidney disease. Kidney Int Suppl (2011) 4, 113-117 (2014)
    • (2014) Kidney Int Suppl (2011) , Issue.4 , pp. 113-117
    • Sharma, K.1    Obesity2
  • 38
    • 55149104161 scopus 로고    scopus 로고
    • Quercetin: Potentials in the prevention and therapy of disease
    • Bischoff, S. C. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11, 733-40 (2008)
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 733-740
    • Bischoff, S.C.1
  • 39
    • 79952641157 scopus 로고    scopus 로고
    • Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines
    • Araujo, J. R., Goncalves, P., & Martel, F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 31, 77-87 (2011)
    • (2011) Nutr Res , vol.31 , pp. 77-87
    • Araujo, J.R.1    Goncalves, P.2    Martel, F.3
  • 40
    • 84929461632 scopus 로고    scopus 로고
    • Quercetin and related polyphenols: New insights and implications for their bioactivity and bioavailability
    • Kawabata, K., Mukai, R., & Ishisaka, A. Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Food Funct 6, 1399-417 (2015)
    • (2015) Food Funct , vol.6 , pp. 1399-1417
    • Kawabata, K.1    Mukai, R.2    Ishisaka, A.3
  • 41
    • 84861468668 scopus 로고    scopus 로고
    • Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model
    • Chen, P. et al. Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Int J Mol Med 30, 119-25 (2012)
    • (2012) Int J Mol Med , vol.30 , pp. 119-125
    • Chen, P.1
  • 42
    • 70350442452 scopus 로고    scopus 로고
    • Alpha-defensins increase lung fibroblast proliferation and collagen synthesis via the beta-catenin signaling pathway
    • Han, W., Wang, W., Mohammed, K. A., & Su, Y. Alpha-defensins increase lung fibroblast proliferation and collagen synthesis via the beta-catenin signaling pathway. FEBS J 276, 6603-14 (2009)
    • (2009) FEBS J , vol.276 , pp. 6603-6614
    • Han, W.1    Wang, W.2    Mohammed, K.A.3    Su, Y.4
  • 43
    • 0033941059 scopus 로고    scopus 로고
    • Modulation of apoptotic and inflammatory genes by bioflavonoids and angiotensin II inhibition in ureteral obstruction
    • Jones, E. A., Shahed, A., & Shoskes, D. A. Modulation of apoptotic and inflammatory genes by bioflavonoids and angiotensin II inhibition in ureteral obstruction. Urology 56, 346-51 (2000)
    • (2000) Urology , vol.56 , pp. 346-351
    • Jones, E.A.1    Shahed, A.2    Shoskes, D.A.3
  • 44
    • 84883864045 scopus 로고    scopus 로고
    • Stereological survey of the ameliorative effects of sulforaphane and quercetin on renal tissue in unilateral ureteral obstruction in rats
    • Noorafshan, A., Karbalay-Doust, S., & Poorshahid, M. Stereological survey of the ameliorative effects of sulforaphane and quercetin on renal tissue in unilateral ureteral obstruction in rats. Acta Clin Croat 51, 555-62 (2012)
    • (2012) Acta Clin Croat , vol.51 , pp. 555-562
    • Noorafshan, A.1    Karbalay-Doust, S.2    Poorshahid, M.3
  • 45
    • 84894133414 scopus 로고    scopus 로고
    • Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages
    • Ishisaka, A. et al. Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages. Plos One 8, e80843 (2013)
    • (2013) Plos One , vol.8 , pp. e80843
    • Ishisaka, A.1
  • 46
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the antiatherosclerotic mechanism of dietary flavonoids
    • Kawai, Y. et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the antiatherosclerotic mechanism of dietary flavonoids. J Biol Chem 283, 9424-34 (2008)
    • (2008) J Biol Chem , vol.283 , pp. 9424-9434
    • Kawai, Y.1
  • 47
    • 84896712417 scopus 로고    scopus 로고
    • The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo
    • Chang, Y. C., Tsai, M. H., Sheu, W. H., Hsieh, S. C., & Chiang, A. N. The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo. Plos One 8, e80744 (2013)
    • (2013) Plos One , vol.8 , pp. e80744
    • Chang, Y.C.1    Tsai, M.H.2    Sheu, W.H.3    Hsieh, S.C.4    Chiang, A.N.5
  • 48
    • 84964051671 scopus 로고    scopus 로고
    • Activation of transient receptor potential ankyrin 1 by quercetin and its analogs
    • Nakamura, T. et al. Activation of transient receptor potential ankyrin 1 by quercetin and its analogs. Biosci Biotechnol Biochem 1, 1-6 (2016)
    • (2016) Biosci Biotechnol Biochem , vol.1 , pp. 1-6
    • Nakamura, T.1
  • 49
    • 73249137593 scopus 로고    scopus 로고
    • Impact of mitochondriotropic quercetin derivatives on mitochondria
    • Biasutto, L. et al. Impact of mitochondriotropic quercetin derivatives on mitochondria. Biochim Biophys Acta 1797, 189-96 (2010)
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 189-196
    • Biasutto, L.1
  • 50
    • 79960108257 scopus 로고    scopus 로고
    • In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose
    • Tang, D. Q. et al. In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose. Fitoterapia 82, 920-6 (2011)
    • (2011) Fitoterapia , vol.82 , pp. 920-926
    • Tang, D.Q.1
  • 51
    • 84864688236 scopus 로고    scopus 로고
    • Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice
    • Hu, Q. H., Zhang, X., Wang, X., Jiao, R. Q., & Kong, L. D. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Eur J Nutr 51, 593-606 (201)
    • Eur J Nutr , vol.51 , Issue.201 , pp. 593-606
    • Hu, Q.H.1    Zhang, X.2    Wang, X.3    Jiao, R.Q.4    Kong, L.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.