메뉴 건너뛰기




Volumn 51, Issue 5, 2012, Pages 593-606

Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice

Author keywords

Hyperuricemia; Quercetin; Renal dysfunction; Renal organic ion transporters; Uromodulin

Indexed keywords

ALLOPURINOL; CARRIER PROTEIN; CREATININE; FLAVONOID; GLUCOSE TRANSPORTER 9; ORGANIC ANION TRANSPORTER 1; ORGANIC CARNITINE TRANSPORTER 1; ORGANIC CARNITINE TRANSPORTER 2; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; OTERACIL; QUERCETIN; RENAL ORGANIC ION TRANSPORTER; RENAL URATE TRANSPORTER 1; TAMM HORSFALL GLYCOPROTEIN; UNCLASSIFIED DRUG; URIC ACID;

EID: 84864688236     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0243-y     Document Type: Article
Times cited : (64)

References (58)
  • 3
    • 0942265459 scopus 로고    scopus 로고
    • Function and localization of urate transporter 1 in mouse kidney
    • Hosoyamada M, Ichida K, Enomoto A et al (2004) Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol 15:261-268
    • (2004) J Am Soc Nephrol , vol.15 , pp. 261-268
    • Hosoyamada, M.1    Ichida, K.2    Enomoto, A.3
  • 4
    • 34547208011 scopus 로고    scopus 로고
    • Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
    • Nigam SK, Bush KT, Bhatnagar V (2007) Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3:443-448
    • (2007) Nat Clin Pract Nephrol , vol.3 , pp. 443-448
    • Nigam, S.K.1    Bush, K.T.2    Bhatnagar, V.3
  • 5
    • 41349103917 scopus 로고    scopus 로고
    • SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
    • Vitart V, Rudan I, Hayward C et al (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40:437-442
    • (2008) Nat Genet , vol.40 , pp. 437-442
    • Vitart, V.1    Rudan, I.2    Hayward, C.3
  • 6
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
    • Preitner F, Bonny O, Laverrière A et al (2009) Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci USA 106:15501-15506
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverrière, A.3
  • 7
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    • Enomoto A, Kimura H, Chairoungdua A et al (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447-452
    • (2002) Nature , vol.417 , pp. 447-452
    • Enomoto, A.1    Kimura, H.2    Chairoungdua, A.3
  • 8
    • 1342302111 scopus 로고    scopus 로고
    • Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes
    • Grover B, Buckley D, Buckley AR et al (2004) Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. J Pharmacol Exp Ther 308:949-956
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 949-956
    • Grover, B.1    Buckley, D.2    Buckley, A.R.3
  • 9
    • 0344364566 scopus 로고    scopus 로고
    • An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
    • Tokuhiro S, Yamada R, Chang X et al (2003) An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 35:341-348
    • (2003) Nat Genet , vol.35 , pp. 341-348
    • Tokuhiro, S.1    Yamada, R.2    Chang, X.3
  • 10
    • 33847213858 scopus 로고    scopus 로고
    • OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)
    • Glube N, Closs E, Langguth P (2007) OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol Pharm 4:160-168
    • (2007) Mol Pharm , vol.4 , pp. 160-168
    • Glube, N.1    Closs, E.2    Langguth, P.3
  • 11
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • Rizwan AN, Burckhardt G (2007) Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 24:450-470
    • (2007) Pharm Res , vol.24 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 12
    • 10744226387 scopus 로고    scopus 로고
    • A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin
    • Dahan K, Devuyst O, Smaers M et al (2003) A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J Am Soc Nephrol 14:2883-2893
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2883-2893
    • Dahan, K.1    Devuyst, O.2    Smaers, M.3
  • 13
    • 0036914069 scopus 로고    scopus 로고
    • Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    • Hart TC, Gorry MC, Hart PS et al (2002) Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 39:882-892
    • (2002) J Med Genet , vol.39 , pp. 882-892
    • Hart, T.C.1    Gorry, M.C.2    Hart, P.S.3
  • 14
    • 70350721790 scopus 로고    scopus 로고
    • Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism
    • Kemter E, Rathkolb B, Rozman J et al (2009) Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol 297:1391-1398
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. 1391-1398
    • Kemter, E.1    Rathkolb, B.2    Rozman, J.3
  • 15
    • 73749083955 scopus 로고    scopus 로고
    • Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a highcardiovascular disease risk phenotype: A double-blinded, placebocontrolled cross-over study
    • Egert S, Bosy-Westphal A, Seiberl J et al (2009) Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a highcardiovascular disease risk phenotype: a double-blinded, placebocontrolled cross-over study. Br J Nutr 102:1065-1074
    • (2009) Br J Nutr , vol.102 , pp. 1065-1074
    • Egert, S.1    Bosy-Westphal, A.2    Seiberl, J.3
  • 16
    • 66949138823 scopus 로고    scopus 로고
    • Antihypertensive effects of the flavonoid quercetin
    • Perez-Vizcaino F, Duarte J, Jimenez R et al (2009) Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep 61:67-75
    • (2009) Pharmacol Rep , vol.61 , pp. 67-75
    • Perez-Vizcaino, F.1    Duarte, J.2    Jimenez, R.3
  • 17
    • 2942532733 scopus 로고    scopus 로고
    • Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
    • Zhu JX, Wang Y, Kong LD et al (2004) Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol 93:133-140
    • (2004) J Ethnopharmacol , vol.93 , pp. 133-140
    • Zhu, J.X.1    Wang, Y.2    Kong, L.D.3
  • 18
    • 34548017059 scopus 로고    scopus 로고
    • Hypouricemic action of selected flavonoids in mice: Structure-activity relationships
    • Mo SF, Zhou F, Lv YZ et al (2007) Hypouricemic action of selected flavonoids in mice: structure-activity relationships. Biol Pharm Bull 30:1551-1556
    • (2007) Biol Pharm Bull , vol.30 , pp. 1551-1556
    • Mo, S.F.1    Zhou, F.2    Lv, Y.Z.3
  • 19
    • 70349647191 scopus 로고    scopus 로고
    • Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement
    • Hu QH, Wang C, Li JM et al (2009) Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol 297:1080-1091
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. 1080-1091
    • Hu, Q.H.1    Wang, C.2    Li, J.M.3
  • 20
    • 22044435401 scopus 로고    scopus 로고
    • The effect of quercetin, a bioflavonoid on ischemia/reperfusion induced renal injury in rats
    • Singh D, Chander V, Chopra K (2004) The effect of quercetin, a bioflavonoid on ischemia/reperfusion induced renal injury in rats. Arch Med Res 35:484-494
    • (2004) Arch Med Res , vol.35 , pp. 484-494
    • Singh, D.1    Chander, V.2    Chopra, K.3
  • 21
    • 77955510512 scopus 로고    scopus 로고
    • Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats
    • Renugadevi J, Prabu SM (2010) Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol 62:471-481
    • (2010) Exp Toxicol Pathol , vol.62 , pp. 471-481
    • Renugadevi, J.1    Prabu, S.M.2
  • 22
    • 31544441357 scopus 로고    scopus 로고
    • Rat gastrointestinal tissues metabolize quercetin
    • Graf BA, Ameho C, Dolnikowski GG et al (2006) Rat gastrointestinal tissues metabolize quercetin. J Nutr 136:39-44
    • (2006) J Nutr , vol.136 , pp. 39-44
    • Graf, B.A.1    Ameho, C.2    Dolnikowski, G.G.3
  • 23
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • Bieger J, Cermak R, Blank R et al (2008) Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 138:1417-1420
    • (2008) J Nutr , vol.138 , pp. 1417-1420
    • Bieger, J.1    Cermak, R.2    Blank, R.3
  • 24
    • 36249009108 scopus 로고    scopus 로고
    • Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3)
    • Hong SS, Seo K, Lim SC et al (2007) Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3). Pharmacol Res 56:468-473
    • (2007) Pharmacol Res , vol.56 , pp. 468-473
    • Hong, S.S.1    Seo, K.2    Lim, S.C.3
  • 25
    • 19444385262 scopus 로고    scopus 로고
    • Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?
    • Ofer M, Wolffram S, Koggel A et al (2005) Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur J Pharm Sci 25:263-271
    • (2005) Eur J Pharm Sci , vol.25 , pp. 263-271
    • Ofer, M.1    Wolffram, S.2    Koggel, A.3
  • 26
    • 56749164877 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models
    • Taur JS, Rodriguez-Proteau R (2008) Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models. Xenobiotica 38:1536-1550
    • (2008) Xenobiotica , vol.38 , pp. 1536-1550
    • Taur, J.S.1    Rodriguez-Proteau, R.2
  • 28
    • 77951205930 scopus 로고    scopus 로고
    • Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice
    • Hu QH, Jiao RQ, Wang X et al (2010) Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice. J Ethnopharmacol 128:685-692
    • (2010) J Ethnopharmacol , vol.128 , pp. 685-692
    • Hu, Q.H.1    Jiao, R.Q.2    Wang, X.3
  • 29
    • 79959212948 scopus 로고    scopus 로고
    • Immunoregulatory effects of the flavonol quercetin in vitro and in vivo
    • Nickel T, Hanssen H, Sisic Z et al (2011) Immunoregulatory effects of the flavonol quercetin in vitro and in vivo. Eur J Nutr 50:163-172
    • (2011) Eur J Nutr , vol.50 , pp. 163-172
    • Nickel, T.1    Hanssen, H.2    Sisic, Z.3
  • 30
    • 35848966547 scopus 로고    scopus 로고
    • Quercetin reduces blood pressure in hypertensive subjects
    • Edwards RL, Lyon T, Litwin SE et al (2007) Quercetin reduces blood pressure in hypertensive subjects. J Nutr 137:2405-2411
    • (2007) J Nutr , vol.137 , pp. 2405-2411
    • Edwards, R.L.1    Lyon, T.2    Litwin, S.E.3
  • 31
    • 53749103108 scopus 로고    scopus 로고
    • A quercetin containing supplement reduces niacin-induced flush in humans
    • Kalogeromitros D, Makris M, Chliva C et al (2008) A quercetin containing supplement reduces niacin-induced flush in humans. Int J Immunopathol Pharmacol 21:509-514
    • (2008) Int J Immunopathol Pharmacol , vol.21 , pp. 509-514
    • Kalogeromitros, D.1    Makris, M.2    Chliva, C.3
  • 33
    • 59949086782 scopus 로고    scopus 로고
    • Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats
    • Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA (2009) Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull 32:61-67
    • (2009) Biol Pharm Bull , vol.32 , pp. 61-67
    • Abdel-Raheem, I.T.1    Abdel-Ghany, A.A.2    Mohamed, G.A.3
  • 34
    • 0037114923 scopus 로고    scopus 로고
    • Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output
    • Perez-Ruiz F, Calabozo M, Erauskin GG et al (2002) Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 47:610-613
    • (2002) Arthritis Rheum , vol.47 , pp. 610-613
    • Perez-Ruiz, F.1    Calabozo, M.2    Erauskin, G.G.3
  • 35
    • 32944472519 scopus 로고    scopus 로고
    • Safety of quercetin for clinical application (review)
    • Okamoto T (2005) Safety of quercetin for clinical application (review). Int J Mol Med 16:275-278
    • (2005) Int J Mol Med , vol.16 , pp. 275-278
    • Okamoto, T.1
  • 36
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF et al (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179-2205
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3
  • 37
    • 0035101387 scopus 로고    scopus 로고
    • Treatment of interstitial cystitis with a quercetin supplement
    • Katske F, Shoskes DA, Sender M et al (2001) Treatment of interstitial cystitis with a quercetin supplement. Tech Urol 7:44-46
    • (2001) Tech Urol , vol.7 , pp. 44-46
    • Katske, F.1    Shoskes, D.A.2    Sender, M.3
  • 38
    • 79952575127 scopus 로고    scopus 로고
    • Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
    • Wong CC, Botting NP, Orfila C et al (2011) Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochem Pharmacol 81:942-949
    • (2011) Biochem Pharmacol , vol.81 , pp. 942-949
    • Wong, C.C.1    Botting, N.P.2    Orfila, C.3
  • 39
    • 18644384361 scopus 로고    scopus 로고
    • Clinico-pathologic findings in medullary cystic kidney disease type 2
    • Bleyer AJ, Hart TC, Willingham MC et al (2005) Clinico-pathologic findings in medullary cystic kidney disease type 2. Pediatr Nephrol 20:824-827
    • (2005) Pediatr Nephrol , vol.20 , pp. 824-827
    • Bleyer, A.J.1    Hart, T.C.2    Willingham, M.C.3
  • 40
    • 0027163031 scopus 로고
    • Uric acid metabolism and tubular sodium handling. Results from a population-based study
    • Cappuccio FP, Strazzullo P, Farinaro E et al (1993) Uric acid metabolism and tubular sodium handling. Results from a population-based study. JAMA 270:354-359
    • (1993) JAMA , vol.270 , pp. 354-359
    • Cappuccio, F.P.1    Strazzullo, P.2    Farinaro, E.3
  • 41
    • 0026318220 scopus 로고
    • Serum uric acid and proximal sodium excretion: An independent association in man (the Olivetti Study)
    • Cappuccio FP, Iacone R, Strazzullo P (1991) Serum uric acid and proximal sodium excretion: an independent association in man (the Olivetti Study). J Hypertens Suppl 9:280-281
    • (1991) J Hypertens Suppl , vol.9 , pp. 280-281
    • Cappuccio, F.P.1    Iacone, R.2    Strazzullo, P.3
  • 42
    • 51549114740 scopus 로고    scopus 로고
    • Oxonic acidinduced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency
    • Eräranta A, Kurra V, Tahvanainen AM et al (2008) Oxonic acidinduced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens 26:1661-1668
    • (2008) J Hypertens , vol.26 , pp. 1661-1668
    • Eräranta, A.1    Kurra, V.2    Tahvanainen, A.M.3
  • 43
    • 65349173645 scopus 로고    scopus 로고
    • Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic
    • Ruiz MJ, Fernández M, Picó Y et al (2009) Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic. J Agric Food Chem 57:3180-3186
    • (2009) J Agric Food Chem , vol.57 , pp. 3180-3186
    • Ruiz, M.J.1    Fernández, M.2    Picó, Y.3
  • 44
    • 0031908477 scopus 로고    scopus 로고
    • Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: Results from an in vitro and a dietary supplement study
    • Janssen K, Mensink RP, Cox FJ et al (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Clin Nutr 67:255-262
    • (1998) Am J Clin Nutr , vol.67 , pp. 255-262
    • Janssen, K.1    Mensink, R.P.2    Cox, F.J.3
  • 45
    • 84864671359 scopus 로고    scopus 로고
    • Detection of quercetin concentrations in propolis from different manufacturing locations by HPLC
    • Chinese
    • Wang XP, Lin L, Bai JQ (2009) Detection of quercetin concentrations in propolis from different manufacturing locations by HPLC. Acta Yunnan Collage Tradit Chin 3:30-32 (in Chinese)
    • (2009) Acta Yunnan Collage Tradit Chin , vol.3 , pp. 30-32
    • Wang, X.P.1    Lin, L.2    Bai, J.Q.3
  • 46
    • 11144335228 scopus 로고    scopus 로고
    • Apple phytochemicals and their health benefits
    • Boyer J, Liu RH (2004) Apple phytochemicals and their health benefits. Nutr J 3:5
    • (2004) Nutr J , vol.3 , pp. 5
    • Boyer, J.1    Liu, R.H.2
  • 47
    • 79953114290 scopus 로고    scopus 로고
    • Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin-induced diabetic rats
    • Jung JY, Lim Y, Moon MS et al (2011) Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin-induced diabetic rats. Nutr Metab (Lond) 8:18
    • (2011) Nutr Metab (Lond) , vol.8 , pp. 18
    • Jung, J.Y.1    Lim, Y.2    Moon, M.S.3
  • 48
    • 38849134933 scopus 로고    scopus 로고
    • Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine
    • Lee KW, Kang NJ, Heo YS et al (2008) Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res 68:946-955
    • (2008) Cancer Res , vol.68 , pp. 946-955
    • Lee, K.W.1    Kang, N.J.2    Heo, Y.S.3
  • 49
    • 33645541093 scopus 로고    scopus 로고
    • The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system
    • Nair MP, Mahajan S, Reynolds JL et al (2006) The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol 13:319-328
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 319-328
    • Nair, M.P.1    Mahajan, S.2    Reynolds, J.L.3
  • 50
    • 79953317030 scopus 로고    scopus 로고
    • Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
    • Kobori M, Masumoto S, Akimoto Y et al (2011) Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol Nutr Food Res 55:530-540
    • (2011) Mol Nutr Food Res , vol.55 , pp. 530-540
    • Kobori, M.1    Masumoto, S.2    Akimoto, Y.3
  • 51
    • 33845505240 scopus 로고    scopus 로고
    • Chronic quercetin exposure affects fatty acid catabolism in rat lung
    • de Boer VC, van Schothorst EM, Dihal AA et al (2006) Chronic quercetin exposure affects fatty acid catabolism in rat lung. Cell Mol Life Sci 63:2847-2858
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2847-2858
    • De Boer, V.C.1    Van Schothorst, E.M.2    Dihal, A.A.3
  • 52
    • 29044437421 scopus 로고    scopus 로고
    • Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats
    • Morales AI, Vicente-Sánchez C, Jerkic M et al (2006) Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharmacol 210:128-135
    • (2006) Toxicol Appl Pharmacol , vol.210 , pp. 128-135
    • Morales, A.I.1    Vicente-Sánchez, C.2    Jerkic, M.3
  • 53
    • 0032558167 scopus 로고    scopus 로고
    • Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: A new class of renoprotective agents
    • Shoskes DA (1998) Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents. Transplantation 66:147-152
    • (1998) Transplantation , vol.66 , pp. 147-152
    • Shoskes, D.A.1
  • 54
    • 33746510896 scopus 로고    scopus 로고
    • Bioavailability of quercetin from berries and the diet
    • Erlund I, Freese R, Marniemi J et al (2006) Bioavailability of quercetin from berries and the diet. Nutr Cancer 54:13-17
    • (2006) Nutr Cancer , vol.54 , pp. 13-17
    • Erlund, I.1    Freese, R.2    Marniemi, J.3
  • 55
    • 0347595571 scopus 로고    scopus 로고
    • Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats
    • Femia AP, Caderni G, Ianni M et al (2003) Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats. Eur J Nutr 42:346-352
    • (2003) Eur J Nutr , vol.42 , pp. 346-352
    • Femia, A.P.1    Caderni, G.2    Ianni, M.3
  • 56
    • 42749089756 scopus 로고    scopus 로고
    • Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout
    • Ahmad NS, Farman M, Najmi MH et al (2008) Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. J Ethnopharmacol 117:478-482
    • (2008) J Ethnopharmacol , vol.117 , pp. 478-482
    • Ahmad, N.S.1    Farman, M.2    Najmi, M.H.3
  • 57
    • 0035100834 scopus 로고    scopus 로고
    • Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin
    • Mulholland PJ, Ferry DR, Anderson D et al (2001) Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Ann Oncol 12:245-248
    • (2001) Ann Oncol , vol.12 , pp. 245-248
    • Mulholland, P.J.1    Ferry, D.R.2    Anderson, D.3
  • 58
    • 57349165877 scopus 로고    scopus 로고
    • Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside
    • Panda S, Kar A (2007) Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside. Biofactors 31:201-210
    • (2007) Biofactors , vol.31 , pp. 201-210
    • Panda, S.1    Kar, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.