A synergistic antiobesity effect by a combination of capsinoids and cold temperature through promoting beige adipocyte biogenesis

Diabetes

Volumn 65, Issue 5, 2016, Pages 1410-1423

  Ohyama, Kana ^a,b   Nogusa, Yoshihito ^a   Shinoda, Kosaku ^b   Suzuki, Katsuya ^a   Bannai, Makoto ^a   Kajimura, Shingo ^b  

^a AJINOMOTO CO INC   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ANTIOBESITY AGENT; BETA 2 ADRENERGIC RECEPTOR; CAPSAICIN DERIVATIVE; CAPSINOID; FORMOTEROL; PROCATEROL; SALMETEROL; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CAPSAICIN; CAPSIATE; DNA BINDING PROTEIN; NORDIHYDROCAPSIATE; PRDM16 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL EXPERIMENT; ARTICLE; BEIGE ADIPOCYTE; BIOGENESIS; COLD EXPOSURE; CONTROLLED STUDY; DIET INDUCED OBESITY; DIETARY SUPPLEMENT; ENERGY EXPENDITURE; GAIN OF FUNCTION MUTATION; LOSS OF FUNCTION MUTATION; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ACCLIMATIZATION; ADIPOGENESIS; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; CHEMISTRY; COLD; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; HYDROGENATION; METABOLISM; OBESITY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; TRANSGENIC MOUSE;

ACCLIMATIZATION; ADIPOCYTES, BEIGE; ADIPOGENESIS; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ANIMALS; ANTI-OBESITY AGENTS; CAPSAICIN; CELLS, CULTURED; COLD TEMPERATURE; DIETARY SUPPLEMENTS; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HYDROGENATION; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; OXYGEN CONSUMPTION; PROTEIN STABILITY; RANDOM ALLOCATION; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84963969740     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0662     Document Type: Article

References (56)

1. Cheung BM, Cheung TT, Samaranayake NR. Safety of antiobesity drugs. Ther Adv Drug Saf 2013;4:171-181
2. Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol 2014;76:225-249
3. Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012;151:400-413
4. Cypess AM, Weiner LS, Roberts-Toler C, et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab 2015;21:33-38
5. Carey AL, Formosa MF, Van Every B, et al. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia 2013;56:147-155
6. Redman LM, de Jonge L, Fang X, et al. Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study. J Clin Endocrinol Metab 2007;92:527-531
7. Kimura K, Sasaki N, Asano A, et al. Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes. Horm Metab Res 2000;32:91-96
8. Piétri-Rouxel F, St. John Manning B, Gros J, Strosberg AD. The biochemical effect of the naturally occurring Trp64?Arg mutation on human beta3-adrenoceptor activity. Eur J Biochem 1997;247:1174-1179
9. Mitchell BD, Blangero J, Comuzzie AG, et al. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. J Clin Invest 1998;101:584-587
10. Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns. Diabetes 1997;46:77-80
11. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013;19:1252-1263
12. Lidell ME, Betz MJ, Dahlqvist Leinhard O, et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013;19:631-634
13. McDonald ME, Li C, Bian H, Smith BD, Layne MD, Farmer SR. Myocardinrelated transcription factor A regulates conversion of progenitors to beige adipocytes. Cell 2015;160:105-118
14. Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes 2014;38:170-176
15. Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One 2012;7:e49452
16. Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376
17. Shinoda K, Luijten IH, Hasegawa Y, et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med 2015;21:389-394
18. Lee P, Linderman JD, Smith S, et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 2014;19:302-309
19. van der Lans AA, Hoeks J, Brans B, et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 2013;123:3395-3403
20. Yoneshiro T, Aita S, Matsushita M, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013;123:3404-3408
21. Kobata K, Sutoh K, Todo T, Yazawa S, Iwai K, Watanabe T. Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, Capsicum annuum. J Nat Prod 1999;62:335-336
22. Kobata KTT, Yazawa S, Iwai K, Watanabe T. Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 Sweet, of pepper (Capsicum annuum L.). J Agric Food Chem 1998;46:1695-1697
23. Ohnuki K, Haramizu S, Oki K, Watanabe T, Yazawa S, Fushiki T. Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 2001;65:2735-2740
24. Snitker S, Fujishima Y, Shen H, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009;89:45-50
25. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949;109:1-9
26. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509
27. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 2012;15:395-404
28. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359
29. Shirai Y, Ueno S, Nakayama A, et al. Studies of the toxicological potential of capsinoids, XII: pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats. Int J Toxicol 2010;29(Suppl.):15S-21S
30. Ono K, Tsukamoto-Yasui M, Hara-Kimura Y, et al. Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. J Appl Physiol (1985) 2011;110:789-798
31. Bachman ES, Dhillon H, Zhang CY, et al. betaAR signaling required for dietinduced thermogenesis and obesity resistance. Science 2002;297:843-845
32. Baker JG. The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors. Br J Pharmacol 2010;160:1048-1061
33. Cohen P, Levy JD, Zhang Y, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 2014;156:304-316
34. Kajimura S, Seale P, Kubota K, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009;460:1154-1158
35. Kajimura S, Seale P, Tomaru T, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008;22:1397-1409
36. Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008;454:961-967
37. Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007;6:38-54
38. Sasahara I, Furuhata Y, Iwasaki Y, et al. Assessment of the biological similarity of three capsaicin analogs (capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. Biosci Biotechnol Biochem 2010;74:274-278
39. Tsurugizawa T, Nogusa Y, Ando Y, Uneyama H. Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate. Eur J Neurosci 2013;38:3628-3635
40. Perkins MN, Rothwell NJ, Stock MJ, Stone TW. Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature 1981;289:401-402
41. Saito M, Minokoshi Y, Shimazu T. Ventromedial hypothalamic stimulation accelerates norepinephrine turnover in brown adipose tissue of rats. Life Sci 1987;41:193-197
42. Beiroa D, Imbernon M, Gallego R, et al. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes 2014;63:3346-3358
43. Martínez de Morentin PB, González-García I, Martins L, et al. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab 2014;20:41-53
44. Morrison SF, Madden CJ, Tupone D. Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab 2014;19:741-756
45. Qiang L, Wang L, Kon N, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell 2012;150:620-632
46. Collins S, Cao W, Robidoux J. Learning new tricks from old dogs: betaadrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol 2004;18:2123-2131
47. Gauthier MS, Miyoshi H, Souza SC, et al. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem 2008;283:16514-16524
48. Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E. Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis. Cell Signal 2009;21:760-766
49. Montgomery MK, Hallahan NL, Brown SH, et al. Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 2013;56:1129-1139
50. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 1998;102:412-420
51. Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 2007;48:41-51
52. Li Y, Bolze F, Fromme T, Klingenspor M. Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains. Biochim Biophys Acta 2014;1841:1345-1352
53. Shabalina IG, Petrovic N, de Jong JM, Kalinovich AV, Cannon B, Nedergaard J. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Reports 2013;5:1196-1203
54. Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011;121:96-105
55. Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 2013;504:163-167
56. Tanaka Y. Research on capsiconinoid contents, nonpungent capsaicinoid analogues, in Capsicum cultivars. Sci Rep Faculty of Agriculture, Okayama University 2014;103:37-43