The biochemical effect of the naturally occurring Trp64→Arg mutation on human β3-adrenoceptor activity

European Journal of Biochemistry

Volumn 247, Issue 3, 1997, Pages 1174-1179

  Piétri Rouxel, Franco ^a   St John Manning, Brian ^a   Gros, Jérôme ^a   Strosberg, A Donny ^a  

^a CNRS   (France)

Author keywords

Guanine nucleotide binding protein coupled receptor; Human; Mutagenesis; 3 adrenoceptor

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; ADENYLATE CYCLASE; ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; ISOPRENALINE; NORADRENALIN;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CYTOCHEMISTRY; GENE EXPRESSION; HAMSTER; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA; CRICETINAE;

EID: 0030789490     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.01174.x     Document Type: Article

References (35)

1. Emorine, L., Blin, N. & Strosberg, A. D. (1994) The human β(3) adrenoceptor - The search for a physiological function, Trends Pharmacol. Sci. 15, 3-6.
2. Giacobino, J. P. (1995) β3-adrenoceptor: an update, Eur. J. Endocrinol. 132, 377-385.
3. Strosberg, A. D. & Pietri-Rouxel, F. (1996) Function and regulation of the β(3)-adrenoceptor, Trends Pharmacol Sci. 17, 373-381.
4. Arch, J. R. S. & Kaumann, A. J. (1993) β3 and atypical β-adrenoceptors. Med. Res. Rev. 13, 663-729.
5. Enocksson, S., Shimizu. M., Lonnqvist, F., Nordenstrom, J. & Arner, P. (1995) Demonstration of an in vivo functional β3-adrenoceptor in man, J. Clin. Invest. 95, 2239-2245.
6. Howe, R. (1993) β3-adrenergic agonists, Drugs Future 18, 529-549.
7. Holloway, B. R., Howe, R., Rao, B. S., Stribling, D., Mayers, R. M., Briscoe, M. G. & Jackson, J. M. (1991) ICI D7114 a novel selective β-adrenoceptor agonist selectively stimulates brown fat and increases whole-body oxygen consumption. Br. J. Pharmacol. 104, 97-104.
8. Hoffstedt, J., Lonnqvist, F., Shimizu, M., Blaak, E. & Arner, P. (1996) Effects of several putative β(3)-adrenoceptor agonists on lipolysis in human omental adipocytes, Int. J. Obes. 20, 428-434.
9. Muzzin, P., Revelli, J.-P., Kuhne, F., Gocayne, J. D., McCombie, W. R., Venter, J. C., Giacobino, J.-P. & Fraser, C. M. (1991) An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity, J. Biol. Chem. 266, 24053-24058.
10. Collins, S., Daniel, K. & Rohlfs, E. (1994) Impaired expression and functional activity of the β3- and β1-adrenergic receptors in the adipose tissue of congenitally obese (c57BL/6J ob/ob) mice, Mol. Endocrinol. 8, 518-527.
11. Susulic, V. S., Frederich, R. C., Lawitts, J., Tozzo, E., Kahn, B. B., Harper, M. E., Himmshagen, J., Flier, J. S. & Lowell, B. B. (1995) Targeted disruption of the β(3)-adrenergic receptor gene. J. Biol. Chem. 270, 29483-29492.
12. Walston, J., Silver, K., Bogardus, C., Knowler, W. C., Celi, F. S., Austin, S., Manning, B., Strosberg, A. D., Stern. M. P., Raben, N., Sorkin, J. D., Roth, J. & Shuldiner, A. R. (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic-receptor gene. N. Engl. J. Med. 333, 343-347.
13. Clement, K., Vaisse, C., Manning, B. S., Basdevant, A., Guy, G. B., Ruiz, J., Silver, K. D., Shuldiner, A. R., Froguel, P. & Strosberg, A. D. (1995) Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity, N. Engl. J. Med. 333, 352-354.
14. Kadowaki, H., Yasuda, K., Iwamoto, K., Otahe, S., Shimokawa, K., Silver, K., Walston, J., Yoshinaga, H., Kosaka, K., Yamada, N., Saito, Y., Hagura, R., Akanuma, Y. Shuldiner, A., Yazaki, Y & Kadowaki, T. (1995) A mutation in the β3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects, Biochem. Biophys. Res. Commun. 215, 555-560.
15. Widen, E., Lehto, M., Kanninen, T, Walston, J., Shuldiner, A. R. & Groop, L. C. (1995) Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns, N. Engl. J. Med. 333, 348-351.
16. KimMotoyama, H., Yasuda, K., Yamaguchi, T., Yamada, N., Katakura, T, Shuldiner, A., Akanuma, Y., Ohashi, Y, Yazaki, Y. & Kadowaki, T. (1997) A mutation of the β3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride, Diabetologia 40, 469-472.
17. Urhammer, S. A., Clausen, J. O., Hansen, T. & Pedersen, O. (1996) Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the β3-adrenergic receptor gene. Diabetes 45, 1115-1120.
18. Mauriege, P. & Bouchard, C. (1996) Trp65Arg mutation in β3-adrenoceptor gene of doubtful significance for obesity and insulin resistance. Lancet 348, 698-699.
19. Strosberg, A. D. & Pietri-Rouxel, F. (1996) Function and regulation of the β3-adrenoceptor. Trends Pharmacol. Sci. 17, 373-381.
20. 50) which causes an enzymatic reaction, Biochem. Pharmacol. 22, 3099-3108.
21. Emorine, L. J., Marullo, S., Briend-Sutren, M.-M., Patey, G., Tate, K., Delavier-Klutchko, C. & Strosberg, A. D. (1989) Molecular characterization of the human β3-adrenergic receptor, Science 245, 1118-1121.
22. Nahmias, C., Blin, N., Elalouf, J.-M., Mattei, M. G., Strosberg, A. D. & Emorine, L. J. (1991) Molecular characterization of the mouse β3-adrenergic receptor: relationship with the atypical receptor of adipocytes, EMBO J. 10, 3721-3727.
23. Granneman, J. G., Lahners, K. N. & Chaudhry, A. (1991) Molecular cloning and expression of the rat β3-adrenergic receptor, Mol. Pharmacol. 40, 895-899.
24. Pietri-Rouxel, F., Lenzen, G., Kapoor, A., Drumare, M. F., Archimbault, P., Strosberg, A. D. & Manning, B. S. (1995) Molecular cloning and pharmacological characterization of the bovine β3-adrenergic receptor, Eur. J. Biochem. 230, 350-358.
25. Candelore, M. R., Deng, L. P. Tota, L. M., Kelly, L. J., Cascieri, M. A. & Strader, C. D. (1996) Pharmacological characterization of a recently described human β3-adrenergic receptor mutant. Endocrinology 137, 2638-2641.
26. Mullaney, I., Shah, B. H., Wise, A. & Milligan, G. (1995) Expression of the human β2-adrenoceptor in NCB20 cells results in agonist activation of adenylyl cyclase and agonist-mediated selective down-regulation of Gs alpha, J. Neurochem. 65, 545-553.
27. Whaley, B. S., Yuan, N., Birnbaumer, L., Clark, R. B. & Barber, R. (1994) Differential expression of the β-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation, Mol. Pharmacol. 45, 481-489.
28. Guan, X. M., Amend, A. & Strader, C. D. (1995) Determination of structural domains for G protein coupling and ligand binding in β3-adrenergic receptor, Mol Pharmacol, 48, 492-498.
29. Chaudhry, A., MacKenzie, R. G., Georgie, L. M. & Granneman, J. G. (1994) Differential interaction of β1- and β3-adrenergic receptors with G, in rat adipocytes, Cell Signal, 6, 457-465.
30. Gauthier, C., Tavernier, G., Charpentier, F., Langin, D. & Lemarec, H. (1996) Functional β(3)-adrenoceptor in the human heart, J. Clin. Invest. 98, 556-562.
31. Van Spronsen, A., Nahmias, C., Krief, S., Briend-Sutren, M. M., Strosberg, A. D. & Emorine, L. J. (1993) The promoter and intron/exon structure of the human and mouse β3-adrenergic-receptor genes. Eur. J. Biochem. 213, 1117-1124.
32. Lowell, B. B. & Flier, J. S. (1995) The potential significance of β3 adrenergic receptors, J. Clin. Invest. 95, 923.
33. Lonnqvist, F., Thome, A., Nilsell. K., Hoffstedt, J. & Arner, P. (1995) A pathogenic role of visceral fat β3-adrenoceptors in obesity, J. Clin. Invest. 95, 1109-1116.
34. Wheeldon, N. M., McDevitt, D. G. & Lipworth, B. J. (1993) Do β3-adrenoceptors mediate metabolic responses to isoprenaline, Q. J. Med. 86, 595-600.
35. Clement, K., Philippi, A., Jury, C., Pividal, R., Hager, J., Demenais, F., Basdevant, A., Guygrand, B. & Froguel, P. (1996) Candidate gene approach of familial morbid obesity: linkage analysis of the glucocorticoid receptor gene. Int. J. Obes. 20, 507-512.