메뉴 건너뛰기




Volumn 23, Issue 3, 2016, Pages R143-R155

TERT promoter mutations in thyroid cancer

Author keywords

BRAF V600E mutation; Diagnosis; Genetic molecular marker; S prognosis; Telomerase reverse; TERT promoter mutation; Thyroid cancer; Transcriptase

Indexed keywords

B RAF KINASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; BRAF PROTEIN, HUMAN; RAS PROTEIN;

EID: 84963959697     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-15-0533     Document Type: Review
Times cited : (327)

References (77)
  • 1
    • 34249862869 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase (hTERT) gene expression in thyroid carcinoma: Diagnostic and prognostic role
    • Asaad NY, Abd El-Wahed MM & Mohammed AG 2006 Human telomerase reverse transcriptase (hTERT) gene expression in thyroid carcinoma: diagnostic and prognostic role. Journal of the Egyptian National Cancer Institute 18 8-16.
    • (2006) Journal of the Egyptian National Cancer Institute , vol.18 , pp. 8-16
    • Asaad, N.Y.1    Abd El-Wahed, M.M.2    Mohammed, A.G.3
  • 5
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: Ageing, cancer and beyond
    • Blasco MA 2005 Telomeres and human disease: ageing, cancer and beyond. Nature Review Genetics 6 611-622. (doi:10.1038/nrg1656)
    • (2005) Nature Review Genetics , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 8
    • 84908335908 scopus 로고    scopus 로고
    • Integrated genomic characterization of papillary thyroid carcinoma
    • Cancer Genome Atlas Research Network 2014 Integrated genomic characterization of papillary thyroid carcinoma. Cell 159 676-690. (doi:10.1016/j.cell.2014.09.050)
    • (2014) Cell , vol.159 , pp. 676-690
    • Cancer Genome Atlas Research Network1
  • 13
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian R & Laird N 1986 Meta-analysis in clinical trials. Controlled Clinical Trials 7 177-188. (doi:10.1016/0197-2456 (86) 90046-2)
    • (1986) Controlled Clinical Trials , vol.7 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 18
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, Jorcano JL & Blasco MA 2001 Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO Journal 20 2619-2630. (doi:10.1093/emboj/20.11.2619)
    • (2001) EMBO Journal , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3    Flores, J.M.4    Martin-Caballero, J.5    Jorcano, J.L.6    Blasco, M.A.7
  • 19
    • 2142825133 scopus 로고    scopus 로고
    • Tracking telomerase
    • Greider CW & Blackburn EH 2004 Tracking telomerase. Cell 116 S83-S86. (doi:10.1016/S0092-8674 (04) 00053-4)
    • (2004) Cell , vol.116 , pp. S83-S86
    • Greider, C.W.1    Blackburn, E.H.2
  • 22
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D & Weinberg RA 2011 Hallmarks of cancer: the next generation. Cell 144 646-674. (doi:10.1016/j.cell.2011.02.013)
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 27
    • 84868674716 scopus 로고    scopus 로고
    • Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation
    • Hrdlickova R, Nehyba J & Bose HR Jr 2012 Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. Molecular Cell Biology 32 4283-4296. (doi:10.1128/MCB. 00550-12)
    • (2012) Molecular Cell Biology , vol.32 , pp. 4283-4296
    • Hrdlickova, R.1    Nehyba, J.2    Bose, H.R.3
  • 28
    • 84874189784 scopus 로고    scopus 로고
    • Highly recurrent TERT promoter mutations in human melanoma
    • Huang FW, Hodis E, Xu MJ, Kryukov GV, Chin L & Garraway LA 2013 Highly recurrent TERT promoter mutations in human melanoma. Science 339 957-959. (doi:10.1126/science.1229259)
    • (2013) Science , vol.339 , pp. 957-959
    • Huang, F.W.1    Hodis, E.2    Xu, M.J.3    Kryukov, G.V.4    Chin, L.5    Garraway, L.A.6
  • 29
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53, 856 cases of thyroid carcinoma treated in the US, 1985-1995 [see comments]
    • Hundahl SA, Fleming ID, Fremgen AM & Menck HR 1998 A National Cancer Data Base report on 53, 856 cases of thyroid carcinoma treated in the US, 1985-1995 [see comments]. Cancer 83 2638-2648. (doi:10. 1002/(SICI) 1097-0142 (19981215) 83:12!2638::AID-CNCR31O3.0. CO;2-1)
    • (1998) Cancer , vol.83 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.M.3    Menck, H.R.4
  • 31
    • 1842828901 scopus 로고    scopus 로고
    • On the road to immortality: HTERT upregulation in cancer cells
    • Janknecht R 2004 On the road to immortality: hTERT upregulation in cancer cells. FEBS Letters 564 9-13. (doi:10.1016/S0014-5793 (04) 00356-4)
    • (2004) FEBS Letters , vol.564 , pp. 9-13
    • Janknecht, R.1
  • 36
    • 84995426988 scopus 로고    scopus 로고
    • Cytologic, clinicopathologic, and molecular features of papillary thyroid carcinoma with prominent hobnail features: 10 case reports and systematic literature review
    • Lee YS, Kim Y, Jeon S, Bae JS, Jung SL & Jung CK 2015 Cytologic, clinicopathologic, and molecular features of papillary thyroid carcinoma with prominent hobnail features: 10 case reports and systematic literature review. International Journal of Clinical and Experimental Pathology 8 7988-7997.
    • (2015) International Journal of Clinical and Experimental Pathology , vol.8 , pp. 7988-7997
    • Lee, Y.S.1    Kim, Y.2    Jeon, S.3    Bae, J.S.4    Jung, S.L.5    Jung, C.K.6
  • 37
    • 84907516385 scopus 로고    scopus 로고
    • Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy
    • Liu R & Xing M 2014 Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy. Endocrine-Related Cancer 21 825-830. (doi:10.1530/ERC-14-0359)
    • (2014) Endocrine-related Cancer , vol.21 , pp. 825-830
    • Liu, R.1    Xing, M.2
  • 38
    • 84877967061 scopus 로고    scopus 로고
    • Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma
    • Liu X, Wu G, Shan Y, Hartmann C, von Deimling A & Xing M 2013a Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. Cell Cycle 12 1637-1638. (doi:10.4161/cc.24662)
    • (2013) Cell Cycle , vol.12 , pp. 1637-1638
    • Liu, X.1    Wu, G.2    Shan, Y.3    Hartmann, C.4    Von Deimling, A.5    Xing, M.6
  • 40
    • 85028141478 scopus 로고    scopus 로고
    • The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas
    • Liu T, Wang N, Cao J, Sofiadis A, Dinets A, Zedenius J, Larsson C & Xu D 2014a The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas. Oncogene 33 4978-4984. (doi:10.1038/onc.2013.446)
    • (2014) Oncogene , vol.33 , pp. 4978-4984
    • Liu, T.1    Wang, N.2    Cao, J.3    Sofiadis, A.4    Dinets, A.5    Zedenius, J.6    Larsson, C.7    Xu, D.8
  • 41
    • 84902303028 scopus 로고    scopus 로고
    • TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer
    • Liu X, Qu S, Liu R, Sheng C, Shi X, Zhu G, Murugan AK, Guan H, Yu H, Wang Y et al. 2014b TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer. Journal of Clinical Endocrinology and Metabolism 99 E1130-E1136. (doi:10.1210/jc. 2013-4048)
    • (2014) Journal of Clinical Endocrinology and Metabolism , vol.99 , pp. E1130-E1136
    • Liu, X.1    Qu, S.2    Liu, R.3    Sheng, C.4    Shi, X.5    Zhu, G.6    Murugan, A.K.7    Guan, H.8    Yu, H.9    Wang, Y.10
  • 42
    • 84883163849 scopus 로고    scopus 로고
    • Telomerase: Central regulator of all of the hallmarks of cancer
    • Low KC & Tergaonkar V 2013 Telomerase: central regulator of all of the hallmarks of cancer. Trends in Biochemical Sciences 38 426-434. (doi:10.1016/j.tibs.2013.07.001)
    • (2013) Trends in Biochemical Sciences , vol.38 , pp. 426-434
    • Low, K.C.1    Tergaonkar, V.2
  • 43
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N & Haenszel W 1959 Statistical aspects of the analysis of data from retrospective studies of disease. Journal of National Cancer Institute 22 719-748.
    • (1959) Journal of National Cancer Institute , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 48
    • 84906819918 scopus 로고    scopus 로고
    • TERT and BRAF in thyroid cancer: Teaming up for trouble
    • Ngeow J & Eng C 2014 TERT and BRAF in thyroid cancer: teaming up for trouble. Journal of Clinical Oncology 32 2683-2684. (doi:10.1200/JCO. 2014.56.5614)
    • (2014) Journal of Clinical Oncology , vol.32 , pp. 2683-2684
    • Ngeow, J.1    Eng, C.2
  • 49
    • 84913605660 scopus 로고    scopus 로고
    • Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay
    • Nikiforov YE, Carty SE, Chiosea SI, Coyne C, Duvvuri U, Ferris RL, Gooding WE, Hodak SP, LeBeau SO, Ohori NP et al. 2014 Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay. Cancer 120 3627-3634. (doi:10.1002/cncr.29038)
    • (2014) Cancer , vol.120 , pp. 3627-3634
    • Nikiforov, Y.E.1    Carty, S.E.2    Chiosea, S.I.3    Coyne, C.4    Duvvuri, U.5    Ferris, R.L.6    Gooding, W.E.7    Hodak, S.P.8    LeBeau, S.O.9    Ohori, N.P.10
  • 50
    • 84890254497 scopus 로고    scopus 로고
    • Targeting thyroid cancer microenvironment: Basic research and clinical applications
    • Nucera C 2013 Targeting thyroid cancer microenvironment: basic research and clinical applications. Frontiers in Endocrinology 4 167. (doi:10.3389/fendo.2013.00167)
    • (2013) Frontiers in Endocrinology , vol.4 , pp. 167
    • Nucera, C.1
  • 52
    • 79953312648 scopus 로고    scopus 로고
    • BRAF (V600E) and microenvironment in thyroid cancer: A functional link to drive cancer progression
    • Nucera C, Lawler J & Parangi S 2011 BRAF (V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Research 71 2417-2422. (doi:10.1158/0008-5472. CAN-10-3844)
    • (2011) Cancer Research , vol.71 , pp. 2417-2422
    • Nucera, C.1    Lawler, J.2    Parangi, S.3
  • 55
    • 77950921126 scopus 로고    scopus 로고
    • The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
    • Saji M & Ringel MD 2010 The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors. Molecular and Cellular Endocrinology 321 20-28. (doi:10.1016/j.mce.2009.10.016)
    • (2010) Molecular and Cellular Endocrinology , vol.321 , pp. 20-28
    • Saji, M.1    Ringel, M.D.2
  • 58
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW & Bacchetti S 1997 A survey of telomerase activity in human cancer. European Journal of Cancer 33 787-791. (doi:10.1016/S0959-8049 (97) 00062-2)
    • (1997) European Journal of Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 59
    • 84927609365 scopus 로고    scopus 로고
    • Association of TERT promoter mutation 1, 295, 228 COT with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer
    • Shi X, Liu R, Qu S, Zhu G, Bishop J, Liu X, Sun H, Shan Z, Wang E, Luo Y et al. 2015 Association of TERT promoter mutation 1, 295, 228 COT with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer. Journal of Clinical Endocrinology and Metabolism 100 E632-E637. (doi:10.1210/jc.2014-3606)
    • (2015) Journal of Clinical Endocrinology and Metabolism , vol.100 , pp. E632-E637
    • Shi, X.1    Liu, R.2    Qu, S.3    Zhu, G.4    Bishop, J.5    Liu, X.6    Sun, H.7    Shan, Z.8    Wang, E.9    Luo, Y.10
  • 61
    • 84952052511 scopus 로고    scopus 로고
    • Multiple mutations detected preoperatively may predict aggressive behavior of papillary thyroid cancer and guide management - A case report
    • Shrestha RT, Karunamurthy A, Amin K, Nikiforov YE & Caramori ML 2015 Multiple mutations detected preoperatively may predict aggressive behavior of papillary thyroid cancer and guide management - a case report. Thyroid 25 1375-1378. (doi:10.1089/thy.2015.0278)
    • (2015) Thyroid , vol.25 , pp. 1375-1378
    • Shrestha, R.T.1    Karunamurthy, A.2    Amin, K.3    Nikiforov, Y.E.4    Caramori, M.L.5
  • 63
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • Smith LL, Coller HA & Roberts JM 2003 Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nature Cell Biology 5 474-479. (doi:10.1038/ncb985)
    • (2003) Nature Cell Biology , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 68
    • 84938138638 scopus 로고    scopus 로고
    • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
    • Wang Z, Zhu B, Zhang M, Parikh H, Jia J, Chung CC, Sampson JN, Hoskins JW, Hutchinson A, Burdette L et al. 2014a Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Human Molecular Genetics 23 6616-6633. (doi:10.1093/hmg/ddu363)
    • (2014) Human Molecular Genetics , vol.23 , pp. 6616-6633
    • Wang, Z.1    Zhu, B.2    Zhang, M.3    Parikh, H.4    Jia, J.5    Chung, C.C.6    Sampson, J.N.7    Hoskins, J.W.8    Hutchinson, A.9    Burdette, L.10
  • 69
    • 84908556575 scopus 로고    scopus 로고
    • TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA
    • Wang N, Liu T, Sofiadis A, Juhlin CC, Zedenius J, Hoog A, Larsson C & Xu D 2014b TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA. Cancer 120 2965-2979. (doi:10.1002/cncr.28800)
    • (2014) Cancer , vol.120 , pp. 2965-2979
    • Wang, N.1    Liu, T.2    Sofiadis, A.3    Juhlin, C.C.4    Zedenius, J.5    Hoog, A.6    Larsson, C.7    Xu, D.8
  • 71
    • 77957220075 scopus 로고    scopus 로고
    • InTERTpreting telomerase structure and function
    • Wyatt HD, West SC & Beattie TL 2010 InTERTpreting telomerase structure and function. Nucleic Acids Research 38 5609-5622. (doi:10.1093/nar/gkq370)
    • (2010) Nucleic Acids Research , vol.38 , pp. 5609-5622
    • Wyatt, H.D.1    West, S.C.2    Beattie, T.L.3
  • 72
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M 2005 BRAF mutation in thyroid cancer. Endocrine-Related Cancer 12 245-262. (doi:10.1677/erc.1.0978)
    • (2005) Endocrine-related Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 73
    • 37349131738 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications
    • Xing M 2007 BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocrine Reviews 28 742-762. (doi:10.1210/er.2007-0007)
    • (2007) Endocrine Reviews , vol.28 , pp. 742-762
    • Xing, M.1
  • 74
    • 78349300635 scopus 로고    scopus 로고
    • Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer
    • Xing M 2010 Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer. Thyroid 20 697-706. (doi:10.1089/thy.2010.1646)
    • (2010) Thyroid , vol.20 , pp. 697-706
    • Xing, M.1
  • 75
    • 84875361065 scopus 로고    scopus 로고
    • Molecular pathogenesis and mechanisms of thyroid cancer
    • Xing M 2013 Molecular pathogenesis and mechanisms of thyroid cancer. Nature Review Cancer 13 184-199. (doi:10.1038/nrc3431)
    • (2013) Nature Review Cancer , vol.13 , pp. 184-199
    • Xing, M.1
  • 76
    • 84906815246 scopus 로고    scopus 로고
    • BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence
    • Xing M, Liu R, Liu X, Murugan AK, Zhu G, Zeiger MA, Pai S & Bishop J 2014a BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. Journal of Clinical Oncology 32 2718-2726. (doi:10.1200/JCO.2014.55.5094)
    • (2014) Journal of Clinical Oncology , vol.32 , pp. 2718-2726
    • Xing, M.1    Liu, R.2    Liu, X.3    Murugan, A.K.4    Zhu, G.5    Zeiger, M.A.6    Pai, S.7    Bishop, J.8
  • 77
    • 84962967709 scopus 로고    scopus 로고
    • TERT promoter and BRAF mutations cooperatively promote papillary thyroid cancer-related mortality
    • Xing M, Liu R & Bishop J 2014b TERT promoter and BRAF mutations cooperatively promote papillary thyroid cancer-related mortality. Thyroid 24 (S1) A-131. (doi:10.1089/thy.2014.2410.abstracts.sc)
    • (2014) Thyroid , vol.24 , Issue.S1 , pp. A-131
    • Xing, M.1    Liu, R.2    Bishop, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.