Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1715-1728

  Remko, Milan ^a   Swart, Marcel ^b   Bickelhaupt, F Matthias ^b  

^a Physics and Informatics   (Slovakia)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Absorption; Centrally acting antihypertensives; Conformational analysis; Lipophilicity; pKa; Polar surface area; Solubility; Solvent effect; Tautomerization

Indexed keywords

AMILORIDE; AMINOPYRROLINE; AMINOTHIAZOLINE; ANTIHYPERTENSIVE AGENT; CLONIDINE; EFAROXAN; HARMAN; IDAZOXAN; IMIDAZOLINE; IMIDAZOLINE RECEPTOR; LNP 911; MOXONIDINE; OXAZOLINE DERIVATIVE; RILMENIDINE; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION CONSTANT; DRUG ABSORPTION; DRUG BINDING; DRUG BINDING SITE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FREQUENCY ANALYSIS; LIPOPHILICITY; PARTITION COEFFICIENT; PKA; POLARIZATION; STRUCTURE ANALYSIS; THEORETICAL STUDY;

EID: 84963951245     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.020     Document Type: Article

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