Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)- amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1588-1593

  Schann, S ^a   Bruban, V ^a   Pompermayer, K ^a   Feldman, J ^a   Pfeiffer, B ^b   Renard, P ^b   Scalbert, E ^c   Bousquet, P ^a   Ehrhardt, J D ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b ADIR   (France)

^c IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; DICYCLOPROPYLMETHYL (4,5 DIMETHYL 4,5 DIHYDRO 3H PYRROL 2 YL)AMINE; IMIDAZOLINE I1 RECEPTOR; IMIDAZOLINE I2 RECEPTOR; LNP 509; PYRROLINE DERIVATIVE; RILMENIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION;

ADRENAL MEDULLA; ANIMALS; ANTIHYPERTENSIVE AGENTS; BINDING SITES; BLOOD PRESSURE; CATTLE; CYCLOPROPANES; FRONTAL LOBE; KIDNEY CORTEX; LIGANDS; MALE; OXAZOLES; PYRROLES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035837070     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001111b     Document Type: Article

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